KEGG   ORTHOLOGY: K15886
Entry
K15886            Tight     KO                                     
Symbol
tcmN
Name
multifunctional cyclase / dehydratase / O-methyltransferase [EC:2.3.1.235]
Pathway
map01056  Biosynthesis of type II polyketide backbone
map01057  Biosynthesis of type II polyketide products
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00778  Type II polyketide backbone biosynthesis, acyl-CoA + malonyl-CoA => polyketide
M00783  Tetracenomycin C/8-demethyltetracenomycin C biosynthesis, tetracenomycin F2 => tetracenomycin C/8-demethyltetracenomycin C
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01056 Biosynthesis of type II polyketide backbone
    K15886  tcmN; multifunctional cyclase / dehydratase / O-methyltransferase
   01057 Biosynthesis of type II polyketide products
    K15886  tcmN; multifunctional cyclase / dehydratase / O-methyltransferase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K15886  tcmN; multifunctional cyclase / dehydratase / O-methyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.235  tetracenomycin F2 synthase
     K15886  tcmN; multifunctional cyclase / dehydratase / O-methyltransferase
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide synthase (PKS)
  Type II PKS
   C7-C14 cyclized polyketide type
    Decaketide PKS
     K15886  tcmN; multifunctional cyclase / dehydratase / O-methyltransferase
 Polyketide tailoring proteins
  Methylase
   K15886  tcmN; multifunctional cyclase / dehydratase / O-methyltransferase
Other DBs
RN: R06701 R09269 R10960
Genes
SGU: SGLAU_26370(tcmN)
Reference
PMID:1548230
  Authors
Summers RG, Wendt-Pienkowski E, Motamedi H, Hutchinson CR
  Title
Nucleotide sequence of the tcmII-tcmIV region of the tetracenomycin C biosynthetic gene cluster of Streptomyces glaucescens and evidence that the tcmN gene encodes a multifunctional cyclase-dehydratase-O-methyl transferase.
  Journal
J Bacteriol 174:1810-20 (1992)
DOI:10.1128/JB.174.6.1810-1820.1992
  Sequence
Reference
  Authors
Ames BD, Korman TP, Zhang W, Smith P, Vu T, Tang Y, Tsai SC
  Title
Crystal structure and functional analysis of tetracenomycin ARO/CYC: implications for cyclization specificity of aromatic polyketides.
  Journal
Proc Natl Acad Sci U S A 105:5349-54 (2008)
DOI:10.1073/pnas.0709223105
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