KEGG ORTHOLOGY: K16542

ORTHOLOGY: K16542

Entry

K16542                      KO

Symbol

CDK5RAP2

Name

CDK5 regulatory subunit-associated protein 2

Disease

H00269

Primary microcephaly

Brite

KEGG Orthology (KO) [BR:ko00001]
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins
    K16542  CDK5RAP2; CDK5 regulatory subunit-associated protein 2
Chromosome and associated proteins [BR:ko03036]
Eukaryotic type
  Centrosome formation proteins
   Pericentriolar materials (PCM)
    Other PCM proteins
     K16542  CDK5RAP2; CDK5 regulatory subunit-associated protein 2
   Centrosome duplication proteins
    Regulators of centriole replication
     K16542  CDK5RAP2; CDK5 regulatory subunit-associated protein 2

Genes

HSA:	55755(CDK5RAP2)

PTR:	464695(CDK5RAP2)

PPS:	100981866(CDK5RAP2)

GGO:	101152803(CDK5RAP2)

PON:	100459050(CDK5RAP2)

PPYG:

129044684(CDK5RAP2)

NLE:	100602733(CDK5RAP2)

HMH:	116475596(CDK5RAP2)

SSYN:

129478955(CDK5RAP2)

MCC:	701442(CDK5RAP2)

MCF:	102132440(CDK5RAP2)

MTHB:

126937635

MNI:	105487136(CDK5RAP2)

CSAB:

103218925(CDK5RAP2)

CATY:

105600348(CDK5RAP2)

PANU:

101006377(CDK5RAP2)

TGE:	112607890(CDK5RAP2)

MLEU:

105546339(CDK5RAP2)

RRO:	104655313(CDK5RAP2)

RBB:	108537078(CDK5RAP2)

TFN:	117098754(CDK5RAP2)

PTEH:

111550323(CDK5RAP2)

CANG:

105501443(CDK5RAP2)

CJC:	100386466(CDK5RAP2)

SBQ:	101043083(CDK5RAP2)

CIMI:

108285833(CDK5RAP2)

ANAN:

105721257(CDK5RAP2)

CSYR:

103258082(CDK5RAP2)

MMUR:

105873661(CDK5RAP2)

LCAT:

123646688(CDK5RAP2)

ERUF:

138388472(CDK5RAP2)

PCOQ:

105826412(CDK5RAP2)

OGA:	100956984(CDK5RAP2)

MMU:	214444(Cdk5rap2)

MCAL:

110292573(Cdk5rap2)

MPAH:

110323260(Cdk5rap2)

RNO:	286919(Cdk5rap2)

MCOC:

116096149(Cdk5rap2)

ANU:	117709204(Cdk5rap2)

ASYL:

127680879(Cdk5rap2)

MMIU:

308438565(CDK5RAP2)

MUN:	110562247(Cdk5rap2)

CGE:	100764684(Cdk5rap2)

MAUA:

101837438(Cdk5rap2)

PROB:

127224886(Cdk5rap2)

PLEU:

114704446(Cdk5rap2)

PMAV:

102915765(Cdk5rap2)

MORG:

121433863(Cdk5rap2)

MFOT:

126497277

AAMP:

119817493(Cdk5rap2)

CNL:	130883960(Cdk5rap2)

NGI:	103734502(Cdk5rap2)

HGL:	101713341(Cdk5rap2)

CPOC:

100734402(Cdk5rap2)

DORD:

105996172(Cdk5rap2)

DSP:	122107089(Cdk5rap2)

DMER:

138820757(Cdk5rap2)

PLOP:

125347663(Cdk5rap2)

NCAR:

124964395

SVUL:

306645140(CDK5RAP2)

MMMA:

107152141(Cdk5rap2)

ITI:	101956529(Cdk5rap2)

OCU:

100351446

OPI:	101516694(CDK5RAP2)

OCZ:	121145092(CDK5RAP2)

TUP:	102488705(CDK5RAP2)

GVR:	103587292(CDK5RAP2)

CFA:	612705(CDK5RAP2)

CLUD:

112650547(CDK5RAP2)

VVP:	112923102(CDK5RAP2)

VLG:	121495385(CDK5RAP2)

NPO:	129494753(CDK5RAP2)

AML:	100465978(CDK5RAP2)

UMR:	103670376(CDK5RAP2)

UAH:	113266345(CDK5RAP2)

UAR:	123788026(CDK5RAP2)

ELK:

111145669

LLV:

125083266

MPUF:

101688850(CDK5RAP2)

MNP:	132024990(CDK5RAP2)

MLK:	131813221(CDK5RAP2)

NVS:	122917309(CDK5RAP2)

MMAQ:

308353000(CDK5RAP2)

ORO:	101386823(CDK5RAP2)

EJU:	114212773(CDK5RAP2)

ZCA:	113934952(CDK5RAP2)

MLX:	118017758(CDK5RAP2)

MANO:

123849950(CDK5RAP2)

NSU:	110581326(CDK5RAP2)

FCA:	101085931(CDK5RAP2)

PYU:	121034902(CDK5RAP2)

PCOO:

112850781(CDK5RAP2)

PBG:	122474902(CDK5RAP2)

PVIV:

125150209(CDK5RAP2)

LRUF:

124503516

LGF:	123593541(CDK5RAP2)

AJU:

106977272

PTG:	102962108(CDK5RAP2)

PPAD:

109269898(CDK5RAP2)

PUC:

125920750

PLEZ:

122205526(CDK5RAP2)

HHV:	120233411(CDK5RAP2)

CCRU:

144236280(CDK5RAP2)

BTA:	508100(CDK5RAP2)

BOM:	102264654(CDK5RAP2)

BIU:	109563401(CDK5RAP2)

BJV:	133253226(CDK5RAP2)

BBUB:

102396750(CDK5RAP2)

BKE:	129650718(CDK5RAP2)

BBIS:

104994773(CDK5RAP2)

CHX:	102178828(CDK5RAP2)

OAS:	101116809(CDK5RAP2)

OCAN:

138433167(CDK5RAP2)

BTAX:

128052031(CDK5RAP2)

CSUM:

138080886(CDK5RAP2)

ODA:	120864717(CDK5RAP2)

CCAD:

122432127(CDK5RAP2)

MREE:

136176586(CDK5RAP2)

OVR:	110145384(CDK5RAP2)

MBEZ:

129557208(CDK5RAP2)

SSC:	100737979(CDK5RAP2)

CFR:	102512729(CDK5RAP2)

CBAI:

105065274(CDK5RAP2)

CDK:	105104552(CDK5RAP2)

VPC:	102525192(CDK5RAP2)

BACU:

103013900(CDK5RAP2)

BMUS:

118897044(CDK5RAP2)

LVE:	103088440(CDK5RAP2)

OOR:	101281578(CDK5RAP2)

LALB:

132523402(CDK5RAP2)

GMF:	115854535(CDK5RAP2)

DDP:	132427118(CDK5RAP2)

SCOO:

307189621(CDK5RAP2)

PCRS:

137227507(CDK5RAP2)

DLE:	111177274(CDK5RAP2)

PCAD:

102983707(CDK5RAP2)

PSIU:

116755379(CDK5RAP2)

PPHC:

136124505(CDK5RAP2)

NASI:

112411295(CDK5RAP2)

HAMP:

307054457(CDK5RAP2)

ECB:	100071839(CDK5RAP2)

EPZ:	103550457(CDK5RAP2)

EAI:	106824203(CDK5RAP2)

MYB:	102241595(CDK5RAP2)

MYD:	102771592(CDK5RAP2)

MMYO:

118667109(CDK5RAP2)

MLF:	102438520(CDK5RAP2)

MDT:	132212327(CDK5RAP2)

MYUM:

139020816(CDK5RAP2)

PKL:	118716100(CDK5RAP2)

EFUS:

103295706(CDK5RAP2)

POTS:

308248477(CDK5RAP2)

MNA:	107537655(CDK5RAP2)

DRO:	112306300(CDK5RAP2)

SHON:

118995972(CDK5RAP2)

AJM:	119035936(CDK5RAP2)

PDIC:

114504013(CDK5RAP2)

PHAS:

123820060(CDK5RAP2)

MMF:	118629273(CDK5RAP2)

PPAM:

129079315(CDK5RAP2)

HAI:	109385733(CDK5RAP2)

RFQ:	117032179(CDK5RAP2)

RHII:

308504588(CDK5RAP2)

PALE:

102896201(CDK5RAP2)

PGIG:

120605776(CDK5RAP2)

PVP:	105292654(CDK5RAP2)

RAY:	107516314(CDK5RAP2)

MJV:	108395552(CDK5RAP2)

TOD:	119231098(CDK5RAP2)

SARA:

101547886(CDK5RAP2)

SFUM:

130045752(CDK5RAP2)

SETR:

126009386(CDK5RAP2)

LAV:	100657337(CDK5RAP2)

TMU:

101352697

ETF:	101649013(CDK5RAP2)

DNM:	101426080(CDK5RAP2)

MDO:	100015115(CDK5RAP2)

GAS:	123237381(CDK5RAP2)

SHR:	100930219(CDK5RAP2)

AFZ:

127550523

PCW:	110211352(CDK5RAP2)

TVP:	118841874(CDK5RAP2)

PBRV:

138150395(CDK5RAP2)

MLAO:

141505676(CDK5RAP2)

OAA:	100078476(CDK5RAP2)

TACU:

119926534(CDK5RAP2)

GGA:	771445(CDK5RAP2)

PCOC:

116234184(CDK5RAP2)

MGP:	100542447(CDK5RAP2)

CJO:	107321845(CDK5RAP2)

TPAI:

128073071(CDK5RAP2)

LMUT:

125702481(CDK5RAP2)

NMEL:

110407108(CDK5RAP2)

APLA:

101792117(CDK5RAP2)

AACU:

137842529(CDK5RAP2)

OJA:	118175620(CDK5RAP2)

BCLA:

308451195(CDK5RAP2)

ACYG:

106037104(CDK5RAP2)

ABRC:

308180578(CDK5RAP2)

CATA:

118252108

AFUL:

116497030(CDK5RAP2)

TGU:	100224435(CDK5RAP2)

LSR:	110482309(CDK5RAP2)

VMC:	128817682(CDK5RAP2)

VCHA:

128798507(CDK5RAP2)

AIB:	137486275(CDK5RAP2)

SCAN:

103819162(CDK5RAP2)

PMOA:

120507446(CDK5RAP2)

OTC:	121336985(CDK5RAP2)

PRUF:

121357601(CDK5RAP2)

ATRC:

139603127(CDK5RAP2)

MATE:

118693434(CDK5RAP2)

MAEN:

136564738(CDK5RAP2)

GFR:	102037317(CDK5RAP2)

FAB:	101817886(CDK5RAP2)

OMA:	130260119(CDK5RAP2)

PHI:	102108408(CDK5RAP2)

PMAJ:

107212078(CDK5RAP2)

CCAE:

111936944(CDK5RAP2)

CCW:	104688251(CDK5RAP2)

CBRC:

103623298

ACOE:

138119545(CDK5RAP2)

ETL:	114054563(CDK5RAP2)

ZAB:	102063841(CDK5RAP2)

ZLE:	135454960(CDK5RAP2)

ACHL:

103812238(CDK5RAP2)

SVG:	106851306(CDK5RAP2)

MMEA:

130578530

LCAI:

146429963(CDK5RAP2)

HRT:	120761691(CDK5RAP2)

SATI:

136369571(CDK5RAP2)

CFAI:

136299415(CDK5RAP2)

CCIC:

134051659(CDK5RAP2)

NNT:	104406655(CDK5RAP2)

SHAB:

115616967(CDK5RAP2)

POCC:

134174933(CDK5RAP2)

PECH:

308227752(CDK5RAP2)

FPG:	101923102(CDK5RAP2)

FCH:	102057187(CDK5RAP2)

FRS:	119153087(CDK5RAP2)

CCRI:

104162079(CDK5RAP2)

ACUN:

113486615(CDK5RAP2)

ANOC:

141968684(CDK5RAP2)

SURA:

141952851(CDK5RAP2)

TALA:

104358954(CDK5RAP2)

ACHC:

115335052(CDK5RAP2)

HALD:

104319216(CDK5RAP2)

HLE:	104833955(CDK5RAP2)

AGEN:

126052044

HHAR:

128154263(CDK5RAP2)

BBUT:

142044065(CDK5RAP2)

GCL:

127023552

CSTI:

104555435(CDK5RAP2)

LDI:	104354732(CDK5RAP2)

MNB:	103779309(CDK5RAP2)

DPUB:

104306146(CDK5RAP2)

PPUS:

135190247(CDK5RAP2)

IIN:	128976186(CDK5RAP2)

AVIT:

104270890(CDK5RAP2)

BRHI:

104497355(CDK5RAP2)

EGZ:	104122680(CDK5RAP2)

NNI:	104022110(CDK5RAP2)

PLEC:

309597749(CDK5RAP2)

PCRI:

104034944

PCAO:

104048287

PARX:

142065739(CDK5RAP2)

PADL:

103912925(CDK5RAP2)

AFOR:

103905272(CDK5RAP2)

FGA:	104079091(CDK5RAP2)

CBOR:

142091331(CDK5RAP2)

GSTE:

104258113(CDK5RAP2)

CBOY:

140661130(CDK5RAP2)

MAME:

142418359(CDK5RAP2)

CLV:	102083946(CDK5RAP2)

CNIC:

135996513(CDK5RAP2)

NMAY:

308047360(CDK5RAP2)

PGUU:

104468673(CDK5RAP2)

PLET:

104624436(CDK5RAP2)

CMAC:

104483442(CDK5RAP2)

CUCA:

104066772(CDK5RAP2)

PCUR:

138729392(CDK5RAP2)

TEO:	104379417(CDK5RAP2)

BREG:

104638081(CDK5RAP2)

GAME:

129215448(CDK5RAP2)

OHA:	104330220(CDK5RAP2)

ACAR:

104527785(CDK5RAP2)

CEUR:

306727826(CDK5RAP2)

CPEA:

104397928(CDK5RAP2)

HEK:	139806671(CDK5RAP2)

CVF:	104289135(CDK5RAP2)

RTD:	128917377(CDK5RAP2)

CRID:

134523669(CDK5RAP2)

LMIC:

141751506(CDK5RAP2)

NARQ:

141473641(CDK5RAP2)

AAM:	106498603(CDK5RAP2)

AROW:

112962970(CDK5RAP2)

NPD:	112955875(CDK5RAP2)

TGT:	104564691(CDK5RAP2)

DNE:	112991337(CDK5RAP2)

SCAM:

104139022(CDK5RAP2)

ASN:	102383560(CDK5RAP2)

AMJ:	102571950(CDK5RAP2)

CPOO:

109313863(CDK5RAP2)

GGN:	109292888(CDK5RAP2)

PSS:	102463173(CDK5RAP2)

CIZ:	142023810(CDK5RAP2)

CMY:	102941932(CDK5RAP2)

CCAY:

125623304(CDK5RAP2)

LKP:	140899229(CDK5RAP2)

NDS:	141999883(CDK5RAP2)

DCC:	119844094(CDK5RAP2)

CPIC:

101947314(CDK5RAP2)

TST:	117889347(CDK5RAP2)

EOB:	135891113(CDK5RAP2)

CABI:

116835234(CDK5RAP2)

MRV:	120386621(CDK5RAP2)

EMQ:	137148920(CDK5RAP2)

ACS:	103280451(cdk5rap2) 103281294

ASAO:

132763644(CDK5RAP2)

PVT:	110078825(CDK5RAP2)

SUND:

121936624(CDK5RAP2)

PBI:	103063731(CDK5RAP2)

PMUR:

107285741(CDK5RAP2)

CTIG:

120298112(CDK5RAP2)

PGUT:

117657180(CDK5RAP2)

PCAE:

139325672(CDK5RAP2)

APRI:

131185989(CDK5RAP2)

PTEX:

113444019(CDK5RAP2)

NSS:	113424872(CDK5RAP2)

VKO:	123028250(CDK5RAP2)

PMUA:

114589385(CDK5RAP2)

PRAF:

128406583(CDK5RAP2)

ZVI:	118084321(CDK5RAP2)

HCG:	128339063(CDK5RAP2)

GJA:	107117967(CDK5RAP2)

STOW:

125442219(CDK5RAP2)

EMC:	129342313(CDK5RAP2)

XLA:	108698304(cdk5rap2.L)

XTR:	733952(cdk5rap2)

NPR:

108801205

RTEM:

120928876

ACAT:

141126651(CDK5RAP2)

BBUF:

120984414

BGAR:

122924119

DRE:	334460(cdk5rap2)

SRX:	107705977 107737169

SANH:

SGH:

CCAR:

CAUA:

CGIB:

PTET:

122332553(cdk5rap2)

LROH:

127152075(cdk5rap2)

GRF:	141292152(cdk5rap2)

OMC:	131528589(cdk5rap2)

PPRM:

120484179(cdk5rap2)

MAMB:

CIDE:

CERY:

MASI:

TROS:

TDW:	130407624(cdk5rap2)

MANU:

129423038(cdk5rap2)

PDAB:

135721480(cdk5rap2)

IPU:	108279141(cdk5rap2)

IFU:	128622632(cdk5rap2)

PHYP:

113535668(cdk5rap2)

SMEO:

124398342(cdk5rap2)

TFD:	113663908(cdk5rap2)

CGAR:

128507306(cdk5rap2)

NGRA:

132895274(cdk5rap2)

AMEX:

103031967(cdk5rap2)

EEE:

113568164

SPIL:

134100513(cdk5rap2)

TRU:	101072545(cdk5rap2)

TFS:	130516870(cdk5rap2)

NCC:

104957839

TBEN:

117476752(cdk5rap2)

CGOB:

115016710(cdk5rap2)

PGEO:

117456086(cdk5rap2)

GACU:

117560214(cdk5rap2)

EMAC:

134868894(cdk5rap2)

ELY:	117269721(cdk5rap2)

EFO:	125905481(cdk5rap2)

PLEP:

121959904(cdk5rap2)

SLUC:

116063014(cdk5rap2)

ECRA:

117959838

ESP:	116704331(cdk5rap2)

PFLV:

114571550(cdk5rap2)

GAT:	120832316(cdk5rap2)

PPUG:

119226725(cdk5rap2)

AFB:	129102106(cdk5rap2)

CLUM:

117740110(cdk5rap2)

PSWI:

130204988(cdk5rap2)

CANA:

137783549(cdk5rap2)

CVE:	137869339(cdk5rap2)

MSAM:

119914905(cdk5rap2)

SCHU:

122865680(cdk5rap2)

EARM:

139301091(cdk5rap2)

CUD:	121525030(cdk5rap2)

SPUL:

138601796(cdk5rap2)

LMIX:

132992272(cdk5rap2)

HTC:	141805110(cdk5rap2)

ALAT:

119030421(cdk5rap2)

ASTR:

137608736(cdk5rap2)

PKLU:

139218761(cdk5rap2)

LCO:	104924508(cdk5rap2)

MZE:	101483352(cdk5rap2)

ONL:	100693979(cdk5rap2)

OAU:	116331864(cdk5rap2)

OLA:

101159208

OML:	112163356(cdk5rap2)

CSAI:

133454972(cdk5rap2)

XMA:

102226128

XCO:	114150216(cdk5rap2)

PRET:

103473504(cdk5rap2)

PFOR:

103151457(cdk5rap2)

PLAI:

106954261(cdk5rap2)

PMEI:

106923841

GAF:	122846796(cdk5rap2)

PPRL:

129374334(cdk5rap2)

CVG:	107089761(cdk5rap2)

CTUL:

119776536(cdk5rap2)

GMU:	124872428(cdk5rap2)

NFU:	107374764(cdk5rap2)

KMR:	108230980(cdk5rap2)

ALIM:

106516279(cdk5rap2)

NWH:	119424288(cdk5rap2)

LTU:

140276832

MCEP:

124996312(cdk5rap2)

AOCE:

111569825(cdk5rap2)

EJA:	138210207(cdk5rap2)

BFRE:

138630965(cdk5rap2)

LCF:

108874015

CSEM:

103390444(cdk5rap2)

POV:	109626243(cdk5rap2)

SSEN:

122761801(cdk5rap2)

SSOE:

131446589(cdk5rap2)

HHIP:

117771705(cdk5rap2)

HSP:	118125408(cdk5rap2)

PPLT:

128462355(cdk5rap2)

SMAU:

118285149(cdk5rap2)

SDU:

111236169

SLAL:

111652416

XGL:	120806216(cdk5rap2)

HCQ:

109523436

SSCV:

125979260(cdk5rap2)

SBIA:

133515291(cdk5rap2)

PEE:	133414155(cdk5rap2)

PTAO:

133490017(cdk5rap2)

BPEC:

110157498

ENY:	140367875(cdk5rap2)

MALB:

109972298(cdk5rap2)

BSPL:

114866433(cdk5rap2)

SJO:	128380526(cdk5rap2)

SSCO:

133995806(cdk5rap2)

TTY:	137171295(cdk5rap2)

GMH:

115532105

SASA:

106570081

STRU:

115159963(cdk5rap2)

OTW:	112220266(cdk5rap2)

OMY:	110523277(cdk5rap2)

OGO:	123989384(cdk5rap2)

ONE:

115115533

OKI:

109868125

OKE:	118387353(cdk5rap2)

OMM:	135518257(cdk5rap2)

OCLA:

139408407

SALP:

111961881

SNH:	120021830 120026379(cdk5rap2)

SFON:

129818892(cdk5rap2)

CCLU:

121542174 121582085(cdk5rap2)

ELS:

105028404

OEP:	134033318(cdk5rap2)

SFM:

108934334

PKI:

111841828

AANG:

118212419(cdk5rap2)

AROT:

135239748(cdk5rap2)

CCOG:

133141448(cdk5rap2)

LOC:	102685280(cdk5rap2)

PSPA:

121307477 121307485

LCM:

102357134

CMK:	103184659(cdk5rap2)

RTP:

CPLA:

HOC:

BFO:

SPU:

APLC:

OTU:

ALAB:

BBIF:

BVK:

BVAN:

BPYO:

MGEN:

NMEA:

CGIG:

PFUC:

VPS:

TPRE:

CGLO:

FAS:

DAM:

AGIF:

CCIN:

CSEC:

DMK:

PJA:

PCHN:

HAME:

PCLA:

PTRU:

HAZT:

HRJ:

CRG:

PMAX:

OSN:

LAK:	106154678(LOC106154678)

NVE:

EPA:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

Reference

PMID:17959831

Authors

Fong KW, Choi YK, Rattner JB, Qi RZ

Title

CDK5RAP2 is a pericentriolar protein that functions in centrosomal attachment of the gamma-tubulin ring complex.

Journal

Mol Biol Cell 19:115-25 (2008)
DOI:10.1091/mbc.E07-04-0371

Sequence

[hsa:55755]

Reference

PMID:18042621

Authors

Graser S, Stierhof YD, Nigg EA

Title

Cep68 and Cep215 (Cdk5rap2) are required for centrosome cohesion.

Journal

J Cell Sci 120:4321-31 (2007)
DOI:10.1242/jcs.020248

Sequence

[hsa:55755]

LinkDB

DBGET integrated database retrieval system