KEGG   ORTHOLOGY: K18364
Entry
K18364                      KO                                     
Symbol
bphH, xylJ, tesE
Name
2-oxopent-4-enoate/cis-2-oxohex-4-enoate hydratase [EC:4.2.1.80 4.2.1.132]
Pathway
map00362  Benzoate degradation
map00621  Dioxin degradation
map00622  Xylene degradation
map00984  Steroid degradation
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
map01220  Degradation of aromatic compounds
Module
M00569  Catechol meta-cleavage, catechol => acetyl-CoA / 4-methylcatechol => propanoyl-CoA
Reaction
R02601  4-hydroxy-2-oxopentanoate hydro-lyase (2-oxopent-4-enoate-forming)
R05864  4-hydroxy-2-oxohexanoate hydro-lyase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00362 Benzoate degradation
    K18364  bphH, xylJ, tesE; 2-oxopent-4-enoate/cis-2-oxohex-4-enoate hydratase
   00622 Xylene degradation
    K18364  bphH, xylJ, tesE; 2-oxopent-4-enoate/cis-2-oxohex-4-enoate hydratase
   00621 Dioxin degradation
    K18364  bphH, xylJ, tesE; 2-oxopent-4-enoate/cis-2-oxohex-4-enoate hydratase
   00984 Steroid degradation
    K18364  bphH, xylJ, tesE; 2-oxopent-4-enoate/cis-2-oxohex-4-enoate hydratase
Enzymes [BR:ko01000]
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.80  2-oxopent-4-enoate hydratase
     K18364  bphH, xylJ, tesE; 2-oxopent-4-enoate/cis-2-oxohex-4-enoate hydratase
    4.2.1.132  2-hydroxyhexa-2,4-dienoate hydratase
     K18364  bphH, xylJ, tesE; 2-oxopent-4-enoate/cis-2-oxohex-4-enoate hydratase
Dioxygenases [br01602.html]
 Dioxygenases in aromatic ring cleavage
  K18364
Other DBs
GO: 0008684 0034856
Genes
PGE: LG71_12240
PLUM: A4R40_11035
PAKH: B0X70_11350
PLUI: CE143_11265
PSD: DSC_09160 DSC_09365
LSY: H8L67_00470(dmpE)
RGL: CS053_01760
RTH: LRK53_10275(dmpE)
RBD: ALSL_1080
VAF: D1115_22450
PATE: NNL38_21635(dmpE)
PRE: PCA10_13820 PCA10_p0350(carD)
PFUW: KF707C_12170 KF707C_15560(bzaF) KF707C_16070(salF) KF707C_16250(bphX1)
PLAL: FXN65_06420
PCQ: PcP3B5_25700(tesE_1)
PNT: G5B91_07425(dmpE)
PPI: ND086(nahL)
PPUT: L483_14065
PPUN: PP4_27260
PPJ: RK21_04237
PZA: HU749_013350
PVR: PverR02_11595 PverR02_14690
PMED: E3Z27_14780
PPUU: PputUW4_01660(mhpD)
PKC: PKB_4239(xylJ)
PFZ: AV641_10535
PLQ: AA042_19765
PALK: PSAKL28_05940
PPSY: AOC04_07835
PFK: PFAS1_28775
PSET: THL1_1433
PSIL: PMA3_11735 PMA3_18070
PKE: DLD99_14750
PUM: HGP31_20760
PPSH: G5J76_13490
PAZE: KSS91_19295
PALV: KSS97_16725
PTAE: NCTC10697_02057(xylJ)
PCAV: D3880_02345(dmpE) D3880_11810(dmpE) D3880_17505
PPHN: HU825_04980(dmpE) HU825_14755
PIZ: LAB08_R28780(dmpE) LAB08_R40970
PKM: PZ739_11545
PSHS: JJN09_05425
PLAU: I0D68_00650(dmpE) I0D68_06180 I0D68_15095(dmpE)
PFOU: OZ911_14080
PBEJ: PSH84_16905
PSKP: KU43P_19440
PDEU: QEP73_19140
PBUB: V6B39_16905
PSML: V6P94_13790
PSMZ: V6L79_14210
PSIV: LZ023_16920
PSWO: SD196_12915
PMOR: PMm318_A52890
PTHV: CE140_07270
PPSE: BN5_3620(nahL)
PALL: UYA_06720 UYA_06980 UYA_07060 UYA_20155
PSC: A458_06520
PSTU: UIB01_22740
PBM: CL52_14710
SDEG: GOM96_01760
AVN: Avin_08670(xylJ) Avin_30610(lapE)
AVL: AvCA_08670(xylJ) AvCA_30610(lapE)
AVD: AvCA6_08670(xylJ) AvCA6_30610(lapE)
ACX: Achr_32780
HPEG: EAO82_00555(dmpE) EAO82_09425(dmpE)
HAES: LO767_17670(dmpE)
HARR: HV822_17975
PPHA: BVH74_06155 BVH74_16350 BVH74_17960
HASM: QAO71_12430
MAD: HP15_1113 HP15_4034
MSR: AU15_21080
MLQ: ASQ50_09215
MSQ: BKP64_13850
MARJ: MARI_05440(xylJ)
MALL: PBN92_01670(dmpE)
MSHE: MAALD49_03410 MAALD49_03860
MANP: EHN06_02445(dmpE)
MAMM: ABNF92_03750(dmpE) ABNF92_09340(dmpE)
KAK: Kalk_07855
SPL: Spea_2118
SHL: Shal_2090
SWD: Swoo_1392
SHEM: HWQ47_08255
COLW: A3Q33_18575
CBER: B5D82_11270
THT: E2K93_11200
PHA: PSHAa2141(xylJ)
PTN: PTRA_a2594(bphH)
PNG: PNIG_a2788(bphH)
HARO: R50071_02970 R50071_12460
SPOI: IMCC21906_00389 IMCC21906_02710
SNAN: I6N98_10800
STAW: NCG89_14300
ZAL: AZF00_03890 AZF00_11430 AZF00_17820
MSPN: M8T91_14350
HJA: BST95_09505
HALC: EY643_13295
AFUS: EYZ66_02605(dmpE) EYZ66_12965
PAQM: E0F26_07475
CYQ: Q91_0508
CZA: CYCME_2103
CYY: CPC19_10515(dmpE)
BLEP: AL038_01300(dmpE)
THIS: HZT40_10605
AEH: Mlg_2460
TBN: TBH_C0928
APAC: S7S_06990
MGEO: CFI10_00425(dmpE) CFI10_04960(dmpE)
MSEC: LN244_04775 LN244_11330(dmpE)
MRZ: KDW95_00770
NCU: F0U83_03045(dmpE)
NJP: NEJAP_0671(mhpD)
NIK: F5I99_10105(dmpE) F5I99_10520(dmpE)
AJP: AMJAP_2999(mhpD)
EMP: EZMO1_1317(tesE)
ASIM: FE240_03500(dmpE)
ZDF: AN401_14585
SOK: D0B54_06200
SINI: GT972_13730(dmpE) GT972_14670
FCE: JN531_005830
GBI: PG2T_02230
GPB: HDN1F_27090(tesE)
NZO: SAMEA4504057_0450(xylJ)
NCI: NCTC10296_00911(xylJ_1)
NWD: H3L96_04745(dmpE)
NDU: LVJ88_00610(dmpE)
VFF: VITFI_CDS1370
PTES: JQU52_04880(dmpE)
USU: LVJ78_03680(dmpE)
CHRO: CXB49_03840
AQL: BXU06_16875
RPI: Rpic_4620
RPF: Rpic12D_3544
RPJ: N234_08150 N234_12215
RIN: ACS15_4354(dmpE)
REH: H16_B0548(mhpD1) H16_B0597(bphH)
CNC: CNE_2c04940(mhpD) CNE_2c05420(xylJ2) CNE_BB1p11990(xylJ1) CNE_BB1p13280(xylJ2)
CUH: BJN34_30960
REU: Reut_A1510 Reut_B5691
RME: Rmet_1321(xylJ)
CTI: RALTA_B0401(mhpD)
CBW: RR42_s2313 RR42_s2484
CCUP: BKK81_19910 BKK81_27090
CUP: BKK80_21900 BKK80_29230
CUU: BKK79_35180
COX: E0W60_07775(dmpE) E0W60_08025(dmpE)
CCAX: KZ686_09995(dmpE)
CUK: KB879_20190(dmpE) KB879_20425(dmpE)
CNAN: A2G96_22770
CUPP: CTP10_R37960(dmpE) CTP10_R38470(dmpE)
BVI: Bcep1808_7603
BUR: Bcep18194_B1459 Bcep18194_B2961
BCJ: BCAM1613
BCEN: DM39_3383(dmpE) DM39_4834(dmpE)
BCEO: I35_5473
BCT: GEM_4111 GEM_5403
BCED: DM42_4993(dmpE) DM42_6345(dmpE)
BCEP: APZ15_31155
BPYR: ABD05_27820
BCON: NL30_04140 NL30_24600
BDF: WI26_15985 WI26_21145
BTEI: WS51_00560 WS51_05695
BPSL: WS57_06045 WS57_12165
BMEC: WJ16_26790
BSTL: BBJ41_10510 BBJ41_21340
BANN: JFN94_19125(dmpE) JFN94_25650(dmpE)
BARI: NLX30_30185(dmpE)
BAEN: L3V59_21740(dmpE) L3V59_30395(dmpE)
BUQ: AC233_11195
BURK: DM992_32625(dmpE)
BURT: BTHE68_57030
BXE: Bxe_C1189(bphH)
BXB: DR64_8616(dmpE)
BUZ: AYM40_21220
BFN: OI25_4589(dmpE)
PARB: CJU94_37870(dmpE) CJU94_38115(dmpE)
PCAF: DSC91_003291
PMEG: FNZ07_21165(dmpE)
PBRY: NDK50_32875(dmpE)
PPAI: E1956_37240(dmpE) E1956_45885
PHUN: U0042_26770(dmpE)
PPK: U875_01900
PRB: X636_07570
PVE: UC34_07065
CABA: SBC2_49020(tesE)
LIMN: HKT17_03820(dmpE)
BOJ: CBF45_01490 CBF45_04500 CBF45_06955
APES: FOC84_00320(dmpE)
AVH: WHX56_04395
CDN: BN940_01166 BN940_04316
KGY: EHF36_01675(dmpE) EHF36_04885(dmpE)
RLH: MIZ03_0646 MIZ03_1022
PNA: Pnap_4144
AJS: Ajs_0222
ACID: CBP33_01105
ACIP: CBP36_01200
ACIN: CBP34_01110
ACIS: CBP35_17750
AMON: H9L24_14185(dmpE)
VEI: Veis_2785
VBO: CKY39_28505(dmpE)
VAV: IG196_08130(dmpE)
VAE: RZE79_18250(dmpE)
CTT: CtCNB1_1353 CtCNB1_3149
CTES: O987_07740
COF: FOZ74_08305(dmpE)
CRJ: QMY55_07020
ADN: Alide_0337
ADK: Alide2_0282
OTD: J1M35_00055(dmpE)
HYL: LPB072_18180
HPSE: HPF_01870(xylJ)
HYN: F9K07_02750(dmpE)
HTN: KI616_01965(dmpE)
DIH: G7047_01670(dmpE) G7047_09705
DRG: H9K76_11645(dmpE)
DIM: K2L43_01275(dmpE)
DIS: I3K84_11925(dmpE)
SIMP: C6571_13615(dmpE)
MELA: C6568_07860(dmpE)
MJE: LVC68_01005(dmpE)
STHM: IS481_10530(dmpE)
SAQA: OMP39_09110(dmpE)
MPT: Mpe_A2273 Mpe_A3325
METP: C1M51_06460(dmpE) C1M51_15400(dmpE)
SNN: EWH46_19325
SMIO: CATMQ487_04110 CATMQ487_17560 CATMQ487_31610
IDC: LRM40_19570(dmpE)
LCH: Lcho_3343
JAG: GJA_236(xylJ)
JAJ: EKL02_01815(dmpE)
HEW: HBDW_03980
MASW: AM586_18650
TMJ: P0M04_30675(dmpE)
ACTB: RHM62_03640
RBU: PG1C_14105
ABRE: pbN1_20560(mhpD)
DAR: Daro_2774 Daro_3785
DEY: HYN24_14130(dmpE) HYN24_14215(dmpE)
DDEN: KI615_16885(dmpE)
FLE: KI610_08575(dmpE) KI610_13420(dmpE) KI610_15465(dmpE)
AZO: azo1853(lapE) azo2434(nahL)
AOA: dqs_2006 dqs_2578
AZI: AzCIB_1507 AzCIB_4411
AZD: CDA09_09955 CDA09_10325(dmpE) CDA09_10440(dmpE) CDA09_21440(dmpE)
AZR: CJ010_12250(dmpE) CJ010_15220(dmpE)
TMZ: Tmz1t_2077 Tmz1t_3091
THU: AC731_001810 AC731_008895
THAU: C4PIVTH_2807(mhpD) C4PIVTH_4321(mhpD) C4PIVTH_4380(mhpD)
THK: CCZ27_10770(dmpE) CCZ27_16275(dmpE)
THAG: CKCBHOJB_02379(tesE_1) CKCBHOJB_03304(tesE_2)
AZQ: G3580_00535(dmpE) G3580_08270(dmpE)
MFUJ: ABC766_18390
MENS: LOK46_22175
RPOP: K1718_22490
PAQT: E8L99_04850
MATG: ACMVPR_11760
TEC: AKL02_008255
FRB: AB6B37_08185
NAR: Saro_3689
NPP: PP1Y_AT32745 PP1Y_Mpl3103
NPN: JI59_22525
NOV: TQ38_027295
NOT: C7W88_20925
NOVO: IM701_15590
SGI: SGRAN_1581(mhpD)
SPOG: EEB18_002715
SPHM: G432_01985
SSAN: NX02_12710
SPKC: KC8_03560
SPHA: D3Y57_15215
SLAN: GV829_01855
SBIN: SBA_ch2_4290
SPCL: F9288_18805
SJP: SJA_C1-11870(mhpD)
SINB: SIDU_08330
SYB: TZ53_09010 TZ53_23455
SPHB: EP837_03394(bphH)
SHYD: CJD35_06490
SUFL: FIL70_19005
SBAR: H5V43_20655
SPCA: GL174_15770
SPJS: NUH86_21125
SFLA: SPHFLASMR4Y_02368(tesE)
SPHJ: BSL82_10455
PALG: HFP57_16665
PHAO: HF685_05520
ALTN: LBX01_06760
PMAS: NCF86_10595
TFV: IDJ81_04970
PHZ: CHX26_05320
NTD: EGO55_13680
CAEN: K5X80_14735
PEG: E5R92_01705
HTL: HPTL_0050
ACIB: ACBT_0261(dmpE)
AFC: AFAEC_1846(dmpE)
AAQI: AAQM_0980(dmpE)
ACLO: ACLO_a0141(dmpE)
ADZ: ADFLV_2553(dmpE)
ARC: ABLL_2444
AROS: NJU99_01640(dmpE)
ALK: ALEK_0381(dmpE)
AANA: AANAER_1258(dmpE)
PRUE: LVJ94_28770
AMOB: HG15A2_23830(tesE)
BHUI: LOK74_00600
BAYD: BSPP4475_07455
BBOR: RFB14_22165
ASED: IRT44_17630
AFAS: NZD89_10100
FFE: LSG31_21095
MHAP: JFY71_09925
CFEU: CFELI_13980(mhpD)
AFUV: AADG42_17625
ACTR: Asp14428_49240
CWO: Cwoe_3997
PARN: NBH00_20090
NAY: HYG81_22605
AG: BAC67694(tesE)
 » show all
Reference
PMID:16151114
  Authors
Horinouchi M, Hayashi T, Koshino H, Kurita T, Kudo T
  Title
Identification of 9,17-dioxo-1,2,3,4,10,19-hexanorandrostan-5-oic acid, 4-hydroxy-2-oxohexanoic acid, and 2-hydroxyhexa-2,4-dienoic acid and related enzymes involved in testosterone degradation in Comamonas testosteroni TA441.
  Journal
Appl Environ Microbiol 71:5275-81 (2005)
DOI:10.1128/AEM.71.9.5275-5281.2005
  Sequence
[ag:BAC67694]
LinkDB

KEGG   ENZYME: 4.2.1.132
Entry
EC 4.2.1.132                Enzyme                                 
Name
2-hydroxyhexa-2,4-dienoate hydratase;
tesE (gene name);
hsaE (gene name)
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
Sysname
4-hydroxy-2-oxohexanoate hydro-lyase [(2Z,4Z)-2-hydroxyhexa-2,4-dienoate-forming]
Reaction(IUBMB)
4-hydroxy-2-oxohexanoate = (2Z,4Z)-2-hydroxyhexa-2,4-dienoate + H2O [RN:R09960]
Reaction(KEGG)
R09960;
(other) R05864
Substrate
4-hydroxy-2-oxohexanoate [CPD:C06762]
Product
(2Z,4Z)-2-hydroxyhexa-2,4-dienoate [CPD:C20240];
H2O [CPD:C00001]
Comment
This enzyme catalyses a late step in the bacterial steroid degradation pathway. The product, 4-hydroxy-2-oxohexanoate, forms a 2-hydroxy-4-hex-2-enolactone under acidic conditions.
History
EC 4.2.1.132 created 2012
Pathway
ec00622  Xylene degradation
ec00984  Steroid degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K18364  2-oxopent-4-enoate/cis-2-oxohex-4-enoate hydratase
Genes
PGE: LG71_12240
PLUM: A4R40_11035
PAKH: B0X70_11350
PLUI: CE143_11265
PSD: DSC_09160 DSC_09365
LSY: H8L67_00470(dmpE)
RGL: CS053_01760
RTH: LRK53_10275(dmpE)
RBD: ALSL_1080
VAF: D1115_22450
PATE: NNL38_21635(dmpE)
PRE: PCA10_13820 PCA10_p0350(carD)
PFUW: KF707C_12170 KF707C_15560(bzaF) KF707C_16070(salF) KF707C_16250(bphX1)
PLAL: FXN65_06420
PCQ: PcP3B5_25700(tesE_1)
PNT: G5B91_07425(dmpE)
PPI: ND086(nahL)
PPUT: L483_14065
PPUN: PP4_27260
PPJ: RK21_04237
PZA: HU749_013350
PVR: PverR02_11595 PverR02_14690
PMED: E3Z27_14780
PPUU: PputUW4_01660(mhpD)
PKC: PKB_4239(xylJ)
PFZ: AV641_10535
PLQ: AA042_19765
PALK: PSAKL28_05940
PPSY: AOC04_07835
PFK: PFAS1_28775
PSET: THL1_1433
PSIL: PMA3_11735 PMA3_18070
PKE: DLD99_14750
PUM: HGP31_20760
PPSH: G5J76_13490
PAZE: KSS91_19295
PALV: KSS97_16725
PTAE: NCTC10697_02057(xylJ)
PCAV: D3880_02345(dmpE) D3880_11810(dmpE) D3880_17505
PPHN: HU825_04980(dmpE) HU825_14755
PIZ: LAB08_R28780(dmpE) LAB08_R40970
PKM: PZ739_11545
PSHS: JJN09_05425
PLAU: I0D68_00650(dmpE) I0D68_06180 I0D68_15095(dmpE)
PFOU: OZ911_14080
PBEJ: PSH84_16905
PSKP: KU43P_19440
PDEU: QEP73_19140
PBUB: V6B39_16905
PSML: V6P94_13790
PSMZ: V6L79_14210
PSIV: LZ023_16920
PSWO: SD196_12915
PMOR: PMm318_A52890
PTHV: CE140_07270
PPSE: BN5_3620(nahL)
PALL: UYA_06720 UYA_06980 UYA_07060 UYA_20155
PSC: A458_06520
PSTU: UIB01_22740
PBM: CL52_14710
SDEG: GOM96_01760
AVN: Avin_08670(xylJ) Avin_30610(lapE)
AVL: AvCA_08670(xylJ) AvCA_30610(lapE)
AVD: AvCA6_08670(xylJ) AvCA6_30610(lapE)
ACX: Achr_32780
HPEG: EAO82_00555(dmpE) EAO82_09425(dmpE)
HAES: LO767_17670(dmpE)
HARR: HV822_17975
PPHA: BVH74_06155 BVH74_16350 BVH74_17960
HASM: QAO71_12430
MAD: HP15_1113 HP15_4034
MSR: AU15_21080
MLQ: ASQ50_09215
MSQ: BKP64_13850
MARJ: MARI_05440(xylJ)
MALL: PBN92_01670(dmpE)
MSHE: MAALD49_03410 MAALD49_03860
MANP: EHN06_02445(dmpE)
MAMM: ABNF92_03750(dmpE) ABNF92_09340(dmpE)
KAK: Kalk_07855
SPL: Spea_2118
SHL: Shal_2090
SWD: Swoo_1392
SHEM: HWQ47_08255
COLW: A3Q33_18575
CBER: B5D82_11270
THT: E2K93_11200
PHA: PSHAa2141(xylJ)
PTN: PTRA_a2594(bphH)
PNG: PNIG_a2788(bphH)
HARO: R50071_02970 R50071_12460
SPOI: IMCC21906_00389 IMCC21906_02710
SNAN: I6N98_10800
STAW: NCG89_14300
ZAL: AZF00_03890 AZF00_11430 AZF00_17820
MSPN: M8T91_14350
HJA: BST95_09505
HALC: EY643_13295
AFUS: EYZ66_02605(dmpE) EYZ66_12965
PAQM: E0F26_07475
CYQ: Q91_0508
CZA: CYCME_2103
CYY: CPC19_10515(dmpE)
BLEP: AL038_01300(dmpE)
THIS: HZT40_10605
AEH: Mlg_2460
TBN: TBH_C0928
APAC: S7S_06990
MGEO: CFI10_00425(dmpE) CFI10_04960(dmpE)
MSEC: LN244_04775 LN244_11330(dmpE)
MRZ: KDW95_00770
NCU: F0U83_03045(dmpE)
NJP: NEJAP_0671(mhpD)
NIK: F5I99_10105(dmpE) F5I99_10520(dmpE)
AJP: AMJAP_2999(mhpD)
EMP: EZMO1_1317(tesE)
ASIM: FE240_03500(dmpE)
ZDF: AN401_14585
SOK: D0B54_06200
SINI: GT972_13730(dmpE) GT972_14670
FCE: JN531_005830
GBI: PG2T_02230
GPB: HDN1F_27090(tesE)
NZO: SAMEA4504057_0450(xylJ)
NCI: NCTC10296_00911(xylJ_1)
NWD: H3L96_04745(dmpE)
NDU: LVJ88_00610(dmpE)
VFF: VITFI_CDS1370
PTES: JQU52_04880(dmpE)
USU: LVJ78_03680(dmpE)
CHRO: CXB49_03840
AQL: BXU06_16875
RPI: Rpic_4620
RPF: Rpic12D_3544
RPJ: N234_08150 N234_12215
RIN: ACS15_4354(dmpE)
REH: H16_B0548(mhpD1) H16_B0597(bphH)
CNC: CNE_2c04940(mhpD) CNE_2c05420(xylJ2) CNE_BB1p11990(xylJ1) CNE_BB1p13280(xylJ2)
CUH: BJN34_30960
REU: Reut_A1510 Reut_B5691
RME: Rmet_1321(xylJ)
CTI: RALTA_B0401(mhpD)
CBW: RR42_s2313 RR42_s2484
CCUP: BKK81_19910 BKK81_27090
CUP: BKK80_21900 BKK80_29230
CUU: BKK79_35180
COX: E0W60_07775(dmpE) E0W60_08025(dmpE)
CCAX: KZ686_09995(dmpE)
CUK: KB879_20190(dmpE) KB879_20425(dmpE)
CNAN: A2G96_22770
CUPP: CTP10_R37960(dmpE) CTP10_R38470(dmpE)
BVI: Bcep1808_7603
BUR: Bcep18194_B1459 Bcep18194_B2961
BCJ: BCAM1613
BCEN: DM39_3383(dmpE) DM39_4834(dmpE)
BCEO: I35_5473
BCT: GEM_4111 GEM_5403
BCED: DM42_4993(dmpE) DM42_6345(dmpE)
BCEP: APZ15_31155
BPYR: ABD05_27820
BCON: NL30_04140 NL30_24600
BDF: WI26_15985 WI26_21145
BTEI: WS51_00560 WS51_05695
BPSL: WS57_06045 WS57_12165
BMEC: WJ16_26790
BSTL: BBJ41_10510 BBJ41_21340
BANN: JFN94_19125(dmpE) JFN94_25650(dmpE)
BARI: NLX30_30185(dmpE)
BAEN: L3V59_21740(dmpE) L3V59_30395(dmpE)
BUQ: AC233_11195
BURK: DM992_32625(dmpE)
BURT: BTHE68_57030
BXE: Bxe_C1189(bphH)
BXB: DR64_8616(dmpE)
BUZ: AYM40_21220
BFN: OI25_4589(dmpE)
PARB: CJU94_37870(dmpE) CJU94_38115(dmpE)
PCAF: DSC91_003291
PMEG: FNZ07_21165(dmpE)
PBRY: NDK50_32875(dmpE)
PPAI: E1956_37240(dmpE) E1956_45885
PHUN: U0042_26770(dmpE)
PPK: U875_01900
PRB: X636_07570
PVE: UC34_07065
CABA: SBC2_49020(tesE)
LIMN: HKT17_03820(dmpE)
BOJ: CBF45_01490 CBF45_04500 CBF45_06955
APES: FOC84_00320(dmpE)
AVH: WHX56_04395
CDN: BN940_01166 BN940_04316
KGY: EHF36_01675(dmpE) EHF36_04885(dmpE)
RLH: MIZ03_0646 MIZ03_1022
PNA: Pnap_4144
AJS: Ajs_0222
ACID: CBP33_01105
ACIP: CBP36_01200
ACIN: CBP34_01110
ACIS: CBP35_17750
AMON: H9L24_14185(dmpE)
VEI: Veis_2785
VBO: CKY39_28505(dmpE)
VAV: IG196_08130(dmpE)
VAE: RZE79_18250(dmpE)
CTT: CtCNB1_1353 CtCNB1_3149
CTES: O987_07740
COF: FOZ74_08305(dmpE)
CRJ: QMY55_07020
ADN: Alide_0337
ADK: Alide2_0282
OTD: J1M35_00055(dmpE)
HYL: LPB072_18180
HPSE: HPF_01870(xylJ)
HYN: F9K07_02750(dmpE)
HTN: KI616_01965(dmpE)
DIH: G7047_01670(dmpE) G7047_09705
DRG: H9K76_11645(dmpE)
DIM: K2L43_01275(dmpE)
DIS: I3K84_11925(dmpE)
SIMP: C6571_13615(dmpE)
MELA: C6568_07860(dmpE)
MJE: LVC68_01005(dmpE)
STHM: IS481_10530(dmpE)
SAQA: OMP39_09110(dmpE)
MPT: Mpe_A2273 Mpe_A3325
METP: C1M51_06460(dmpE) C1M51_15400(dmpE)
SNN: EWH46_19325
SMIO: CATMQ487_04110 CATMQ487_17560 CATMQ487_31610
IDC: LRM40_19570(dmpE)
LCH: Lcho_3343
JAG: GJA_236(xylJ)
JAJ: EKL02_01815(dmpE)
HEW: HBDW_03980
MASW: AM586_18650
TMJ: P0M04_30675(dmpE)
ACTB: RHM62_03640
RBU: PG1C_14105
ABRE: pbN1_20560(mhpD)
DAR: Daro_2774 Daro_3785
DEY: HYN24_14130(dmpE) HYN24_14215(dmpE)
DDEN: KI615_16885(dmpE)
FLE: KI610_08575(dmpE) KI610_13420(dmpE) KI610_15465(dmpE)
AZO: azo1853(lapE) azo2434(nahL)
AOA: dqs_2006 dqs_2578
AZI: AzCIB_1507 AzCIB_4411
AZD: CDA09_09955 CDA09_10325(dmpE) CDA09_10440(dmpE) CDA09_21440(dmpE)
AZR: CJ010_12250(dmpE) CJ010_15220(dmpE)
TMZ: Tmz1t_2077 Tmz1t_3091
THU: AC731_001810 AC731_008895
THAU: C4PIVTH_2807(mhpD) C4PIVTH_4321(mhpD) C4PIVTH_4380(mhpD)
THK: CCZ27_10770(dmpE) CCZ27_16275(dmpE)
THAG: CKCBHOJB_02379(tesE_1) CKCBHOJB_03304(tesE_2)
AZQ: G3580_00535(dmpE) G3580_08270(dmpE)
MFUJ: ABC766_18390
MENS: LOK46_22175
RPOP: K1718_22490
PAQT: E8L99_04850
MATG: ACMVPR_11760
TEC: AKL02_008255
FRB: AB6B37_08185
NAR: Saro_3689
NPP: PP1Y_AT32745 PP1Y_Mpl3103
NPN: JI59_22525
NOV: TQ38_027295
NOT: C7W88_20925
NOVO: IM701_15590
SGI: SGRAN_1581(mhpD)
SPOG: EEB18_002715
SPHM: G432_01985
SSAN: NX02_12710
SPKC: KC8_03560
SPHA: D3Y57_15215
SLAN: GV829_01855
SBIN: SBA_ch2_4290
SPCL: F9288_18805
SJP: SJA_C1-11870(mhpD)
SINB: SIDU_08330
SYB: TZ53_09010 TZ53_23455
SPHB: EP837_03394(bphH)
SHYD: CJD35_06490
SUFL: FIL70_19005
SBAR: H5V43_20655
SPCA: GL174_15770
SPJS: NUH86_21125
SFLA: SPHFLASMR4Y_02368(tesE)
SPHJ: BSL82_10455
PALG: HFP57_16665
PHAO: HF685_05520
ALTN: LBX01_06760
PMAS: NCF86_10595
TFV: IDJ81_04970
PHZ: CHX26_05320
NTD: EGO55_13680
CAEN: K5X80_14735
PEG: E5R92_01705
HTL: HPTL_0050
ACIB: ACBT_0261(dmpE)
AFC: AFAEC_1846(dmpE)
AAQI: AAQM_0980(dmpE)
ACLO: ACLO_a0141(dmpE)
ADZ: ADFLV_2553(dmpE)
ARC: ABLL_2444
AROS: NJU99_01640(dmpE)
ALK: ALEK_0381(dmpE)
AANA: AANAER_1258(dmpE)
PRUE: LVJ94_28770
AMOB: HG15A2_23830(tesE)
BHUI: LOK74_00600
BAYD: BSPP4475_07455
BBOR: RFB14_22165
ASED: IRT44_17630
AFAS: NZD89_10100
FFE: LSG31_21095
MHAP: JFY71_09925
CFEU: CFELI_13980(mhpD)
AFUV: AADG42_17625
ACTR: Asp14428_49240
CWO: Cwoe_3997
PARN: NBH00_20090
NAY: HYG81_22605
 » show all
Reference
1  [PMID:16151114]
  Authors
Horinouchi M, Hayashi T, Koshino H, Kurita T, Kudo T
  Title
Identification of 9,17-dioxo-1,2,3,4,10,19-hexanorandrostan-5-oic acid, 4-hydroxy-2-oxohexanoic acid, and 2-hydroxyhexa-2,4-dienoic acid and related enzymes involved in testosterone degradation in Comamonas testosteroni TA441.
  Journal
Appl Environ Microbiol 71:5275-81 (2005)
DOI:10.1128/AEM.71.9.5275-5281.2005
  Sequence
[ag:BAC67694]
Other DBs
ExplorEnz - The Enzyme Database: 4.2.1.132
IUBMB Enzyme Nomenclature: 4.2.1.132
ExPASy - ENZYME nomenclature database: 4.2.1.132
UM-BBD (Biocatalysis/Biodegradation Database): 4.2.1.132
BRENDA, the Enzyme Database: 4.2.1.132
LinkDB

KEGG   REACTION: R05864
Entry
R05864                      Reaction                               
Name
4-hydroxy-2-oxohexanoate hydro-lyase
Definition
2-Hydroxy-cis-hex-2,4-dienoate + H2O <=> 4-Hydroxy-2-oxohexanoic acid
Equation
C11354 + C00001 <=> C06762
Reaction class
RC02676  C06762_C11354
Enzyme
4.2.1.132
Pathway
rn00622  Xylene degradation
rn00984  Steroid degradation
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
rn01220  Degradation of aromatic compounds
Module
M00569  Catechol meta-cleavage, catechol => acetyl-CoA / 4-methylcatechol => propanoyl-CoA
Brite
Enzymatic reactions [BR:br08201]
 4. Lyase reactions
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.132
     R05864  2-Hydroxy-cis-hex-2,4-dienoate + H2O <=> 4-Hydroxy-2-oxohexanoic acid
Orthology
K18364  2-oxopent-4-enoate/cis-2-oxohex-4-enoate hydratase [EC:4.2.1.80 4.2.1.132]
LinkDB

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