KEGG   ORTHOLOGY: K18565
Entry
K18565                      KO                                     
Symbol
thnG, cmmG
Name
2-oxoglutarate-dependent dioxygenase [EC:1.14.20.-]
Pathway
map00332  Carbapenem biosynthesis
map01110  Biosynthesis of secondary metabolites
Reaction
R10740  2,3-dihydrothienamycin,2-oxoglutarate:oxygen oxidoreductase (dehydrating)
R10741  epithienamycin-F,2-oxoglutarate:oxygen oxidoreductase (dehydrating)
R10742  epithienamycin-E,2-oxoglutarate:oxygen oxidoreductase (sulfoxidation)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00332 Carbapenem biosynthesis
    K18565  thnG, cmmG; 2-oxoglutarate-dependent dioxygenase
Genes
SFA: Sfla_0162
STRP: F750_6859
SFIY: F0344_10125
SCT: SCAT_p0826(thnG)
SCY: SCATT_p09090
Reference
  Authors
Bodner MJ, Phelan RM, Freeman MF, Li R, Townsend CA
  Title
Non-heme iron oxygenases generate natural structural diversity in carbapenem antibiotics.
  Journal
J Am Chem Soc 132:12-3 (2010)
DOI:10.1021/ja907320n
Reference
  Authors
Rodriguez M, Nunez LE, Brana AF, Mendez C, Salas JA, Blanco G
  Title
Mutational analysis of the thienamycin biosynthetic gene cluster from Streptomyces cattleya.
  Journal
Antimicrob Agents Chemother 55:1638-49 (2011)
DOI:10.1128/AAC.01366-10
  Sequence
Reference
  Authors
Li R, Lloyd EP, Moshos KA, Townsend CA
  Title
Identification and characterization of the carbapenem MM 4550 and its gene cluster in Streptomyces argenteolus ATCC 11009.
  Journal
Chembiochem 15:320-31 (2014)
DOI:10.1002/cbic.201300319
LinkDB

DBGET integrated database retrieval system