KEGG   REACTION: R10742
Entry
R10742                      Reaction                               
Name
epithienamycin-E,2-oxoglutarate:oxygen oxidoreductase (sulfoxidation)
Definition
Epithienamycin E + 2-Oxoglutarate + Oxygen <=> MM 4550 + Succinate + CO2
Equation
C11755 + C00026 + C00007 <=> C20815 + C00042 + C00011
Comment
proposed pathway
not yet characterized sufficiently
Reaction class
RC03269  C11755_C20815
Enzyme
1.14.20.-
Pathway
rn00332  Carbapenem biosynthesis
rn01110  Biosynthesis of secondary metabolites
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.20  With 2-oxoglutarate as one donor, and the other dehydrogenated
    1.14.20.-
     R10742  Epithienamycin E + 2-Oxoglutarate + Oxygen <=> MM 4550 + Succinate + CO2
Orthology
K18565  2-oxoglutarate-dependent dioxygenase [EC:1.14.20.-]
Reference
1  [PMID:24420617]
  Authors
Li R, Lloyd EP, Moshos KA, Townsend CA
  Title
Identification and characterization of the carbapenem MM 4550 and its gene cluster in Streptomyces argenteolus ATCC 11009.
  Journal
Chembiochem 15:320-31 (2014)
DOI:10.1002/cbic.201300319
LinkDB

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