KEGG ORTHOLOGY: K19385

ORTHOLOGY: K19385

Entry

K19385                      KO

Symbol

TMEM216

Name

transmembrane protein 216

Disease

H00261

Meckel syndrome

H00527

Retinitis pigmentosa

H00530

Joubert syndrome and related disorders

Brite

KEGG Orthology (KO) [BR:ko00001]
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   03037 Cilium and associated proteins
    K19385  TMEM216; transmembrane protein 216
Cilium and associated proteins [BR:ko03037]
Primary cilia and associated proteins
  MKS complex
   K19385  TMEM216; transmembrane protein 216

Genes

HSA:	51259(TMEM216)

PTR:	738173(TMEM216)

PPS:	100975847(TMEM216)

GGO:	101130315(TMEM216)

PON:	100439134(TMEM216)

PPYG:

129008924(TMEM216)

NLE:	100591907(TMEM216)

HMH:	116468856(TMEM216)

SSYN:

129483791(TMEM216)

MCC:	693655(TMEM216)

MCF:	102133820(TMEM216)

MTHB:

126935531

MNI:	105469407(TMEM216)

CSAB:

103234446(TMEM216)

CATY:

105577591(TMEM216)

PANU:

101001129(TMEM216)

TGE:	112606295(TMEM216)

MLEU:

105549011(TMEM216)

RRO:	104679387(TMEM216)

RBB:	108533615(TMEM216)

TFN:	117079819(TMEM216)

PTEH:

111524309(TMEM216)

CANG:

105512301(TMEM216)

CJC:	100415756(TMEM216)

SBQ:	101048891(TMEM216)

CIMI:

108297189(TMEM216)

ANAN:

105718617(TMEM216)

CSYR:

103249436(TMEM216)

MMUR:

105878634(TMEM216)

LCAT:

123641256(TMEM216)

PCOQ:

105825038(TMEM216)

OGA:	100957564(TMEM216)

MMU:	68642(Tmem216)

MCAL:

110285706(Tmem216)

MPAH:

110329500(Tmem216)

RNO:	361727(Tmem216)

MCOC:

116103556(Tmem216)

ANU:	117713140(Tmem216)

ASYL:

127690583(Tmem216)

MUN:	110548099(Tmem216)

CGE:	100772399(Tmem216)

MAUA:

106020966(Tmem216)

PROB:

127228852(Tmem216)

PLEU:

114703424(Tmem216)

MORG:

121454455(Tmem216)

MFOT:

126498228

AAMP:

119820607(Tmem216)

NGI:	103729113(Tmem216)

HGL:	101707388(Tmem216)

CPOC:

100726374(Tmem216)

CCAN:

109685938(Tmem216)

DORD:

105995388(Tmem216)

DSP:	122105046(Tmem216)

PLOP:

125361624(Tmem216)

NCAR:

124959769

MMMA:

107135895(Tmem216)

ITI:	101973833(Tmem216)

OCU:

100343681

OPI:	101523010(TMEM216)

TUP:	102494510(TMEM216)

GVR:	103592905(TMEM216)

CFA:	100688144(TMEM216)

CLUD:

112659547(TMEM216)

VVP:	112911062(TMEM216)

VLG:	121501754(TMEM216)

NPO:	129501765(TMEM216)

AML:	100471958(TMEM216)

UMR:	103678164(TMEM216)

UAH:	113246930(TMEM216)

UAR:	123785117(TMEM216)

ELK:

111150250

LLV:

125080175

MPUF:

101683231(TMEM216)

MNP:	132020311(TMEM216)

MLK:	131813583(TMEM216)

NVS:	122894682 122912982(TMEM216)

ORO:	101368749(TMEM216)

EJU:	114220178(TMEM216)

ZCA:	113913943(TMEM216)

MLX:	118015918(TMEM216)

NSU:	110576320(TMEM216)

LWW:	102737352(TMEM216)

FCA:	101081832(TMEM216)

PYU:	121043328(TMEM216)

PCOO:

112852151(TMEM216)

PBG:	122483857(TMEM216)

PVIV:

125176217(TMEM216)

LRUF:

124504712

LGF:	123601790(TMEM216)

AJU:

106977855

PTG:	102954967(TMEM216)

PPAD:

109246545(TMEM216)

PUC:

125932650

PLEZ:

122200483(TMEM216)

HHV:	120246148(TMEM216)

BTA:	508031(TMEM216)

BOM:	102276341(TMEM216) 102281701

BIU:	109554343(TMEM216)

BBUB:

102411045(TMEM216)

BBIS:

104983603(TMEM216)

CHX:	102176021(TMEM216)

OAS:	101107146(TMEM216)

BTAX:

128068573(TMEM216)

CSUM:

138083426(TMEM216)

ODA:	120874535(TMEM216)

CCAD:

122430534(TMEM216)

MREE:

136168813(TMEM216)

OVR:	110153023(TMEM216)

MBEZ:

129548452(TMEM216)

SSC:	100519467(TMEM216)

CFR:	102503777(TMEM216)

CBAI:

105070105(TMEM216)

CDK:	105094879(TMEM216)

VPC:	102524734(TMEM216)

BACU:

103011911(TMEM216)

BMUS:

118899418(TMEM216)

LVE:	103086754(TMEM216)

OOR:	101272407(TMEM216)

LALB:

132525134(TMEM216)

DLE:	111184097(TMEM216)

PCAD:

102992183(TMEM216) 112061872 112062111

PSIU:

116757064 116757336(TMEM216)

NASI:

112402256(TMEM216)

ECB:	100629684(TMEM216)

EPZ:	103563962(TMEM216)

EAI:	106847570(TMEM216)

MYB:	102257106(TMEM216)

MYD:	102761147(TMEM216)

MMYO:

118649097(TMEM216)

MLF:	102430930(TMEM216)

MDT:	132241573(TMEM216)

MYUM:

139017767(TMEM216)

PKL:	118707312(TMEM216)

EFUS:

103303333(TMEM216)

MNA:	107527644(TMEM216)

DRO:	112317183(TMEM216)

SHON:

118996907(TMEM216)

AJM:	119043691(TMEM216)

PDIC:

114498601(TMEM216)

PHAS:

123829283(TMEM216)

MMF:	118628339(TMEM216)

PPAM:

129062715(TMEM216)

HAI:	109390026(TMEM216)

RFQ:	117029874(TMEM216) 117035108

PALE:

102896525(TMEM216)

PGIG:

120600878(TMEM216)

PVP:	105297779(TMEM216) 105310344

RAY:	107504756(TMEM216)

MJV:	108392388(TMEM216)

TOD:	119250106(TMEM216)

SFUM:

130039678(TMEM216)

SETR:

126017898(TMEM216)

LAV:	100655203(TMEM216)

TMU:

101348962

ETF:	101648623(TMEM216)

DNM:	101447186(TMEM216)

MDO:	100029865(TMEM216)

GAS:	123249729 123253062(TMEM216)

SHR:	100933176(TMEM216)

AFZ:

127539830

PCW:	110195482(TMEM216)

TVP:	118853816(TMEM216) 118854933

PBRV:

138177379(TMEM216)

OAA:	100088124(TMEM216)

TACU:

119943329(TMEM138)

GGA:	777441(TMEM216)

PCOC:

116243032(TMEM216)

MGP:	100551104(TMEM216)

CJO:	107314204(TMEM216)

TPAI:

128087128(TMEM216)

LMUT:

125695348(TMEM216)

NMEL:

110400872(TMEM216)

APLA:

119717083(TMEM216)

ACYG:

106048272(TMEM216)

CATA:

118244722(TMEM216)

AFUL:

116490174(TMEM216)

TGU:	100222948(TMEM216)

LSR:	110484953(TMEM216)

SCAN:

103822268(TMEM216)

PMOA:

120499560(TMEM216)

OTC:	121340089(TMEM216)

PRUF:

121355191(TMEM216)

ATRC:

139590522(TMEM216)

GFR:	102037566(TMEM216)

FAB:	101812507(TMEM216)

OMA:	130254001(TMEM216)

PHI:	102109979(TMEM216)

PMAJ:

107206222(TMEM216)

CCAE:

111945913(TMEM216)

CCW:	104684143(TMEM216)

CBRC:

103611843(TMEM216)

ACOE:

138111085(TMEM216)

ETL:	114063357(TMEM216)

ZAB:	113460523(TMEM216)

ZLE:	135448968(TMEM216)

ACHL:

103810243(TMEM216)

SVG:	106854639(TMEM216)

MMEA:

130580108(TMEM216)

HRT:	120753791(TMEM216)

SATI:

136362131(TMEM216)

CCIC:

134045154(TMEM216)

FPG:	101917074(TMEM216)

FCH:	102056431(TMEM216)

SHAB:

115607008(TMEM216)

TALA:

116961854(TMEM216)

ACHC:

115351596(TMEM216)

HLE:	104829858(TMEM216)

AGEN:

126047146

HHAR:

128153126(TMEM216)

GCL:

127016465

DPUB:

104299792(TMEM216)

PPUS:

135186035(TMEM216)

NNI:	104009156(TMEM216)

AFOR:

103896256(TMEM216)

CLV:	102083580(TMEM216)

PLET:

104620060

CUCA:

104064457(TMEM216)

CPEA:

104398172(TMEM216)

CVF:	104288859(TMEM216)

RTD:	128909641(TMEM216)

CRID:

134514983(TMEM216)

AAM:	106494876(TMEM216)

AROW:

112960809(TMEM216)

DNE:	112988630(TMEM216)

SCAM:

104140693(TMEM216)

ASN:	102379929(TMEM216)

AMJ:	102561920(TMEM216)

PSS:	102445842(TMEM216)

CMY:	102935692(TMEM216)

CCAY:

125637724(TMEM216)

DCC:	119857988(TMEM216)

CPIC:

101933948(TMEM216)

TST:	117875985(TMEM216)

CABI:

116822492(TMEM216)

MRV:	120402765(TMEM216)

ACS:	100567992(tmem138)

ASAO:

132772142(TMEM216)

PVT:	110078347(TMEM216)

PBI:	103055713(TMEM216)

PMUR:

107292659(TMEM216)

CTIG:

120308339(TMEM216)

TSR:	106545948(TMEM216)

PGUT:

117667045(TMEM216)

APRI:

131184297(TMEM216)

PTEX:

113449145(TMEM216)

NSS:	113421923(TMEM216)

VKO:	123021173(TMEM138)

PMUA:

114600724(TMEM216)

PRAF:

128417930(TMEM216)

ZVI:	118089304(TMEM216)

HCG:	128340655(TMEM216)

GJA:	107121402(TMEM216)

STOW:

125427435(TMEM216)

EMC:	129324377(TMEM216)

XLA:	100381030(tmem216.L)

XTR:	100490116(tmem216)

NPR:	108794175(TMEM216)

RTEM:

120917248(TMEM216)

BBUF:

120980484(TMEM216)

BGAR:

122920935(TMEM216)

PWL:	138284469(TMEM216)

MUO:	115468961(TMEM216)

GSH:	117352301(TMEM216)

DRE:	555988(tmem216)

SRX:

107756683

SANH:

107662032 107664744

SGH:	107598329 107601180

CCAR:

109101382(tmem216)

CAUA:

113058104 113101101

CGIB:

128027051

PTET:

122357914(tmem216)

LROH:

127176599(tmem216)

OMC:	131553962(tmem216)

PPRM:

120464810(tmem216)

RKG:	130084719(tmem216)

MAMB:

125259421(tmem216)

CIDE:

127494306

CERY:

137020041(tmem216)

MASI:

127417880

TROS:

130563473(tmem216)

TDW:	130437837(tmem216)

MANU:

129422173(tmem216)

PDAB:

135748395 135753392

IPU:	108268819(tmem216)

IFU:	128611476(tmem216)

PHYP:

113529271

SMEO:

124385659(tmem216)

TFD:	113635887(tmem216)

TVC:	132855864(tmem216)

CGAR:

128532120(tmem216)

NGRA:

132890796(tmem216)

TRN:	134318996(tmem216)

AMEX:

103022549(tmem216)

CMAO:

118806404(si:rp71-1d10.5)

EEE:

113573370

CHAR:

105913105(tmem216)

SPIL:

134069027(tmem216)

TRU:

101074531

TFS:

130531497

LCO:

104934783

TBEN:

117484236(si:rp71-1d10.5)

CGOB:

115005458

PGEO:

117454254(tmem216)

GACU:

117549677(si:rp71-1d10.5)

EMAC:

134859385(tmem216)

ELY:	117259525(si:rp71-1d10.5)

EFO:	125894378(tmem216)

SLUC:

116062536(si:rp71-1d10.5)

PFLV:

114563161

GAT:	120817492(tmem216)

PPUG:

119210076(tmem216)

AFB:	129090434(tmem216)

PSWI:

130209815(tmem216)

CANA:

137803492(tmem216)

MSAM:

119889352(tmem216)

SCHU:

122880685(tmem216)

CUD:	121516639(tmem216)

SPUL:

138598084(tmem216)

LMIX:

132982232(tmem216)

ALAT:

119007353(si:rp71-1d10.5)

ASTR:

137602582(tmem216) 137602909

MZE:

101465550

ONL:

100700830

OAU:	116329682(tmem216)

OLA:

101173074

OML:	112137841(si:rp71-1d10.5)

CSAI:

133446771(tmem216)

XMA:

XCO:

XHE:

PRET:

PFOR:

PLAI:

PMEI:

GAF:	122836879(tmem216)

PPRL:

129354955

CVG:	107087526(tmem216)

CTUL:

119777309(tmem216)

GMU:	124859881(tmem216)

NFU:

107380795

KMR:	108249982(si:rp71-1d10.5)

ALIM:

106530295

NWH:	119408648(tmem216)

AOCE:

111585393(tmem216)

EJA:	138194902(tmem216)

BFRE:

138635494(tmem216)

MCEP:

125008309(tmem216)

CSEM:

103391080

POV:	109641675(tmem216)

SSEN:

122763020(tmem216)

SSOE:

131472351(tmem216)

HHIP:

117769160(si:rp71-1d10.5)

HSP:	118112252(tmem216)

PPLT:

128446125(tmem216)

SMAU:

118319185(tmem216)

LCF:	108889680(tmem216)

SDU:	111232740(tmem216)

SLAL:

111662580(tmem216)

XGL:	120785309(tmem216)

HCQ:

109516470

SSCV:

125987756(tmem216)

SBIA:

133509222(tmem216)

PEE:	133407549(tmem216)

PTAO:

133484705(tmem216)

BPEC:

110166081(tmem216)

ENY:	140366106(tmem216)

MALB:

109956767

BSPL:

114864063(tmem216)

SJO:	128362861(tmem216)

SSCO:

133985993(tmem216)

GMH:

115552534

SASA:

100286545(tmm80) 106604173

STRU:

115167183 115205729

OTW:	112221261(tmem216)

OMY:	110489209(si:rp71-1d10.5)

OGO:	123994195 124011593

ONE:	115130992(tmem216)

OKE:	118380387(tmem216)

OMM:	135526753(tmem216)

OCLA:

139366092

SALP:

111966006 111967185

SNH:	120046909 120062514

CCLU:

121530769 121538666

ELS:

105030668

SFM:

108923136

PKI:	111836423(tmem216)

AANG:

118223759(si:rp71-1d10.5)

AROT:

135251080(tmem216)

CCOG:

133124950(tmem216)

LOC:

102687123

PSPA:

121330197(tmem216)

ARUT:

117434938

PSEX:

120530819

LCM:	102361577(TMEM216)

CMK:

RTP:

CPLA:

HOC:

LERI:

PMRN:

LRJ:

BFO:

BBEL:

CIN:

SCLV:

SPU:	591901 594538

LPIC:

AJJ:

APLC:

ARUN:

AAMU:

AFIL:

AJC:

SKO:

PFLL:

DME:	Dmel_CG11760(CG11760) Dmel_CG8116(TMEM216)

DER:	6552438 6552439

DSE:	6607220 6607221

DSI:	Dsimw501_GD18565(Dsim_GD18565) Dsimw501_GD18566(Dsim_GD18566)

DYA:	Dyak_GE25897 Dyak_GE25898

DAN:	6500960 6500961

DSR:	110188758 110188759

DPO:	4803007 6897886

DPE:	6594565 6594566

DMN:	108155022 108155023

DWI:	6647986 6647987

DGR:	6564027 6564028

DMO:	Dmoj_GI22390 Dmoj_GI22391

DAZ:	108618892 108618898

DNV:	108660285 108660286

DHE:	111603649 111603650

DVI:	6629261 6629262(TMEM216)

CCAT:

101454302 105664491

BOD:	106616664 106616665

BDR:	105231599 125776090

RZE:	108359302 108359303

AOQ:	129244877 129244887

ALUD:

128867996 128868009

TDA:	119680330 119680331

MDE:	101888258 101889757

SCAC:

106081481 106081482

LCQ:	111676156 111676157

LSQ:	119616177 119616178

CVJ:	135962514 135962525(TMEM216)

GFS:	119638356 119638357

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AMAP:

AFUN:

AMOU:

AMRS:

AALI:

ACOS:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ006109

CPII:

120414949

CNS:	116350365 116350366 116350381

BCOO:

LLL:

PPAP:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BHUN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

COBS:

TLN:

HST:

DQU:

CFO:

FEX:

PMEC:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:	105273659 105273660

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

AROA:

TCA:	656829 664180

TMOL:

138132495 138136374

DPA:	109533259 109543003 125502776

ESIM:

136414770 136415851 136417989

EFOR:

136339437 136342448

SOY:	115882296 115882410 115890104

AGRG:

126734874

ATD:	109594566 109595357

CSET:

123312137 123315623

HAXR:

123677879

AGB:	108905198 108911729 108915208

LDC:	111507178 111508101 111508103 111514405

DVV:	114328527 126889479

NVL:	108557146 108568032 108568033

DCOR:

135800567

APLN:

108736733 108738968 112905908

PPYR:

116161699 116161700 116164635

OTU:	111425066 111425077 111428131

BMOR:

101742567

BMAN:

114241542 114247327

MSEX:

115442851 115444244

DPL:	KGM_207219 KGM_210027

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:	106116156 106116167

BPHI:

137926010

PRAP:

110991851 110997269

PBX:	123708874 123712195

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:	110373601 110373605

HZE:	124641806 124641960

TNL:	113494804 113494891 113494892 113506239 113507790

SLIU:

111357294 111357305

OFU:	114361216 114363582

ONU:

135083933

ATRA:

106130685 106130781

GMW:	113514384 113514563

PXY:

105382515

PGW:	126377239 126377267

LGLY:

CSTB:

CFEL:

CCRN:

API:

DNX:

AGS:

RMD:

BTAB:

NLU:

PHU:	Phum_PHUM079910

FOC:

TPAL:

IEL:

HAMR:

PVM:

PJA:

PMOO:

PTRU:

EAF:

TCF:

PPOI:

DSV:

RSAN:

VDE:

VJA:

CSCU:

CVS:

ABRU:

SDM:

LPOL:

CEL:	CELE_C30B5.9(mks-2)

CRQ:	GCK72_006196

NAI:	NECAME_06523

BMY:	BM_BM2481(Bma-mks-2)

LOA:	LOAG_03667

LGI:	LOTGIDRAFT_204590

PVUL:

PCAN:

LSAX:

BGT:

GAE:

HRF:

HRJ:

HASI:

HCRA:

CRG:

CANU:

CVN:

OED:

MYI:

PMAX:

AIRR:

MCAF:

MMER:

RPHI:

DPOL:

MAEA:

OBI:

OSN:

LJP:

LAK:

SMM:	Smp_114590

LLON:

NVE:

EPA:

ATEN:

ADF:

AMIL:

MCAZ:

MFOO:

PDAM:

SPIS:

DGT:

XEN:

HMG:

HSY:

RES:

AQU:

CRE:	CHLRE_08g379750v5

VCN:	VOLCADRAFT_121132

MNG:	MNEG_15869

MIS:	MICPUN_62907

MPP:	MICPUCDRAFT_49281 MICPUCDRAFT_51008

TGO:	TGME49_278460

TET:	TTHERM_00842510

PTM:	GSPATT00006545001 GSPATT00011306001

SPAR:

SPRG_05194

TBR:	Tb927.4.3710

TBG:	TbgDal_IV3665

TCR:	506201.150

LMA:	LMJF_34_0705

LIF:	LINJ_34_0740

LDO:	LDBPK_340740

LMI:	LMXM_33_0705

LMAT:

92512231(LSCM1_02131)

LOI:	92356840(LSCM4_00834)

LEIS:

94177382(GH5_01823)

LENR:

94168682(CUR178_01401)

LEIN:

94185164(JIQ42_01422)

PHET:

94287790(JKF63_01667)

TVA:	TVAG_2v0581100

EHX:	EMIHUDRAFT_222967

GTT:	GUITHDRAFT_150704

» show all

Reference

PMID:22282472

Authors

Lee JH, Silhavy JL, Lee JE, Al-Gazali L, Thomas S, Davis EE, Bielas SL, Hill KJ, Iannicelli M, Brancati F, Gabriel SB, Russ C, Logan CV, Sharif SM, Bennett CP, Abe M, Hildebrandt F, Diplas BH, Attie-Bitach T, Katsanis N, Rajab A, Koul R, Sztriha L, Waters ER, Ferro-Novick S, Woods CG, Johnson CA, Valente EM, Zaki MS, Gleeson JG

Title

Evolutionarily assembled cis-regulatory module at a human ciliopathy locus.

Journal

Science 335:966-9 (2012)
DOI:10.1126/science.1213506

Sequence

[hsa:51259]

LinkDB

DBGET integrated database retrieval system