KEGG   ORTHOLOGY: K19436
Entry
K19436                      KO                                     
Symbol
ICP0, RL2
Name
Simplexvirus E3 ubiquitin-protein ligase ICP0
Pathway
map05168  Herpes simplex virus 1 infection
Network
nt06168  Herpes simplex virus 1 (HSV-1)
nt06517  TLR signaling
nt06520  CGAS-STING signaling
nt06524  Apoptosis
  Element
N00561  HSV ICP0 to TLR2/4-NFKB signaling pathway
N00570  HSV ICP0 to cGAS-STING signaling pathway
N00580  HSV ICP0 to crosstalk between extrinsic and intrinsic apoptotic pathways
N00588  HSV VP16 to Oct-1-mediated transcription
N00592  HSV ICP0 to p53-mediated transcription
Brite
KEGG Orthology (KO) [BR:ko00001]
 09160 Human Diseases
  09172 Infectious disease: viral
   05168 Herpes simplex virus 1 infection
    K19436  ICP0, RL2; Simplexvirus E3 ubiquitin-protein ligase ICP0
 09180 Brite Hierarchies
  09185 Viral protein families
   03200 Viral proteins
    K19436  ICP0, RL2; Simplexvirus E3 ubiquitin-protein ligase ICP0
Viral proteins [BR:ko03200]
 dsDNA viruses
  Human herpes simplex virus 1/2
   K19436  ICP0, RL2; Simplexvirus E3 ubiquitin-protein ligase ICP0
Genes
VG: 1487288(RL2) 1487289(RL2) 1487469(RL2) 1487480(RL2) 18533891(RL2) 18533950(RL2) 2703389(RL2) 2703390(RL2) 3190344(RL2) 3190348(RL2) 3850209(RL2) 3850211(RL2)
Reference
PMID:20075863
  Authors
Lilley CE, Chaurushiya MS, Boutell C, Landry S, Suh J, Panier S, Everett RD, Stewart GS, Durocher D, Weitzman MD
  Title
A viral E3 ligase targets RNF8 and RNF168 to control histone ubiquitination and DNA damage responses.
  Journal
EMBO J 29:943-55 (2010)
DOI:10.1038/emboj.2009.400
  Sequence
[vg:2703390]
LinkDB

DBGET integrated database retrieval system