KEGG   NETWORK: N00588
Entry
N00588                      Network                                
Name
HSV VP16 to Oct-1-mediated transcription
Definition
(VP16+HCF+POU2F1) => (ICP0,ICP4,ICP22,ICP27,ICP47)
  Expanded
(K19444+(3054,29915)+5451) => (K19436,K19445,K19441,K19443,K19446)
Class
nt06140 Transcription (viruses)
nt06168 Herpes simplex virus 1 (HSV-1)
Type
Pathogen
Pathway
hsa05168  Herpes simplex virus 1 infection
Disease
H00365  Herpes simplex virus infection
Gene
3054  HCFC1; host cell factor C1
29915  HCFC2; host cell factor C2
5451  POU2F1; POU class 2 homeobox 1
Perturbant
K19444 (VP16)  UL48; Simplexvirus tegument protein VP16
K19436 (ICP27)  ICP0; Simplexvirus E3 ubiquitin-protein ligase ICP0
K19445 (ICP47)  ICP4; Simplexvirus major viral transcription factor ICP4
K19441 ()  US1; Simplexvirus transcriptional regulator ICP22
K19443 ()  UL54; Simplexvirus mRNA export factor
K19446 ()  US12; HSV1 ICP47 protein
Reference
  Authors
Wysocka J, Herr W
  Title
The herpes simplex virus VP16-induced complex: the makings of a regulatory switch.
  Journal
Trends Biochem Sci 28:294-304 (2003)
DOI:10.1016/S0968-0004(03)00088-4
Reference
  Authors
LaBoissiere S, O'Hare P
  Title
Analysis of HCF, the cellular cofactor of VP16, in herpes simplex virus-infected cells.
  Journal
J Virol 74:99-109 (2000)
DOI:10.1128/jvi.74.1.99-109.2000
Reference
  Authors
Pesola JM, Zhu J, Knipe DM, Coen DM
  Title
Herpes simplex virus 1 immediate-early and early gene expression during reactivation from latency under conditions that prevent infectious virus production.
  Journal
J Virol 79:14516-25 (2005)
DOI:10.1128/JVI.79.23.14516-14525.2005
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