KEGG ORTHOLOGY: K19605

ORTHOLOGY: K19605

Entry

K19605                      KO

Symbol

EVC1

Name

ellis van creveld syndrome protein 1

Pathway

map04340

Hedgehog signaling pathway

Disease

H00503

Ellis-van Creveld syndrome

H01376

Acrofacial dysostosis

H02158

Weyers acrofacial dysostosis

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04340 Hedgehog signaling pathway
    K19605  EVC1; ellis van creveld syndrome protein 1
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   03037 Cilium and associated proteins
    K19605  EVC1; ellis van creveld syndrome protein 1
Cilium and associated proteins [BR:ko03037]
Primary cilia and associated proteins
  EVC complex
   K19605  EVC1; ellis van creveld syndrome protein 1

Genes

HSA:

2121(EVC)

PTR:	461097(EVC)

PPS:	100996222(EVC)

GGO:	101138183(EVC)

PON:	100435979(EVC)

PPYG:

129034922(EVC)

NLE:	100595240(EVC)

HMH:	116456775(EVC)

SSYN:

129464338(EVC)

MCC:	711266(EVC)

MCF:	102129962(EVC)

MTHB:

126955483

MNI:	105483919(EVC)

CSAB:

103246400(EVC)

CATY:

105585417(EVC)

PANU:

101023369(EVC)

TGE:	112624265(EVC)

MLEU:

105555311(EVC)

RRO:	104667569(EVC)

RBB:	108538795(EVC)

TFN:	117085117(EVC)

PTEH:

111539134(EVC)

CANG:

105507086(EVC)

CJC:	100415445(EVC)

SBQ:	101032550(EVC)

CIMI:

108311634(EVC)

ANAN:

105727237(EVC)

CSYR:

103268784(EVC)

MMUR:

105857363(EVC)

LCAT:

123622185(EVC)

PCOQ:

105825157(EVC)

OGA:	100955176(EVC)

MMU:	59056(Evc)

MCAL:

110295146(Evc)

MPAH:

110330621(Evc)

RNO:	289712(Evc)

MCOC:

116070489(Evc)

ANU:	117712994(Evc)

MUN:	110544913(Evc)

CGE:	100771932(Evc)

MAUA:

101836274(Evc)

PROB:

127233700(Evc)

PLEU:

114702079(Evc)

MORG:

121436489(Evc)

MFOT:

126500846

AAMP:

119819097(Evc)

NGI:	103739552(Evc)

HGL:	101719227(Evc)

CPOC:

100731437(Evc)

CCAN:

109695695(Evc)

DORD:

105991289(Evc)

DSP:	122099775(Evc)

PLOP:

125364546(Evc)

NCAR:

124994544

MMMA:

107138911(Evc)

OCU:

103345885

OPI:	101516327(EVC)

TUP:	102484433(EVC)

GVR:	103585393(EVC)

CFA:	611166(EVC)

CLUD:

112653180(EVC)

VVP:	112919688(EVC)

VLG:	121489528(EVC)

NPO:	129510247(EVC)

AML:	100470532(EVC)

UMR:	103658344(EVC)

UAH:	113266662(EVC)

UAR:	123775791(EVC)

ELK:

111149104

LLV:

125093527

MPUF:

101672297(EVC)

MNP:	132004325(EVC)

MLK:	131826367(EVC)

NVS:	122890552(EVC)

ORO:	101362801(EVC)

EJU:	114198141(EVC)

ZCA:	113925735(EVC)

MLX:	118010173(EVC)

NSU:	110569734(EVC)

FCA:	101092515(EVC)

PYU:	121043122(EVC)

PCOO:

112858269(EVC)

PBG:	122479063(EVC)

PVIV:

125164509(EVC)

LRUF:

124520980

PTG:	102969411(EVC)

PPAD:

109269694(EVC)

PUC:

125923931

AJU:

106982721

HHV:	120231799(EVC)

BTA:	282874(EVC)

BOM:	102271648(EVC) 102273071

BIU:	109560665(EVC)

BBUB:

102389190(EVC)

BBIS:

104994288(EVC)

CHX:	102189937(EVC)

OAS:	101113496(EVC)

BTAX:

128049598(EVC)

ODA:	120862229(EVC)

CCAD:

122428054(EVC)

MBEZ:

129561617(EVC)

SSC:	100620576(EVC)

CFR:	102508548(EVC)

CBAI:

105083256(EVC)

CDK:	105085112(EVC)

VPC:	102544729(EVC)

BACU:

103014528(EVC)

BMUS:

118895452(EVC)

LVE:	103083610(EVC)

OOR:	101274339(EVC)

DLE:	111171458(EVC)

PCAD:

102981406(EVC)

PSIU:

116754215(EVC)

NASI:

112397566(EVC)

ECB:	100070005(EVC)

EPZ:

103562776

EAI:	106832487(EVC)

MYB:	102245005(EVC)

MYD:	102773260(EVC)

MMYO:

118666358(EVC)

MLF:

102425542

MDT:	132221686(EVC)

PKL:	118709018(EVC)

EFUS:

103294544(EVC)

MNA:	107530086(EVC)

DRO:	112316682(EVC)

SHON:

118987018(EVC)

AJM:	119035551(EVC)

PDIC:

114492794(EVC)

PHAS:

123815614(EVC)

MMF:	118643198(EVC)

PPAM:

129077678(EVC)

HAI:	109392581(EVC)

RFQ:	117022009(EVC)

PALE:

102892696(EVC)

PGIG:

120582859(EVC)

PVP:	105301836(EVC)

RAY:	107519024(EVC)

MJV:	108400119(EVC)

TOD:	119260201(EVC)

SARA:

101537942(EVC)

SETR:

126020189(EVC)

LAV:	100654876(EVC)

TMU:

101343801

ETF:	101651424(EVC)

DNM:	101431230(EVC)

MDO:	100018722(EVC)

GAS:	123251079(EVC)

SHR:	100921888(EVC)

AFZ:

127539635

PCW:	110212260(EVC)

TVP:	118852633(EVC)

OAA:	103168574(EVC)

GGA:	422851(EVC)

PCOC:

116225789(EVC)

MGP:

100549359

CJO:	107313926(EVC)

TPAI:

128079940(EVC)

LMUT:

125692522(EVC)

NMEL:

110397559(EVC)

APLA:

101791730(EVC)

ACYG:

106035167(EVC)

CATA:

118248388(EVC)

AFUL:

116488987(EVC)

TGU:	100218032(EVC)

LSR:	110481885(EVC)

SCAN:

103826133(EVC)

PMOA:

120511623(EVC)

OTC:	121335190(EVC)

PRUF:

121348988(EVC)

GFR:	102033801(EVC)

FAB:	101810416(EVC)

OMA:	130252506(EVC)

PHI:	102110311(EVC)

PMAJ:

107203086(EVC)

CCAE:

111928472(EVC)

CCW:	104690910(EVC)

CBRC:

103611166(EVC)

ETL:	114061464(EVC)

ZAB:	102067311(EVC)

ZLE:	135447050(EVC)

ACHL:

103800334(EVC)

SVG:	106865328(EVC)

MMEA:

130577856(EVC)

HRT:	120753434(EVC)

SATI:

136360193(EVC)

FPG:	101910491(EVC)

FCH:	102050431(EVC)

CCRI:

104162857(EVC)

NNT:

104408563

SHAB:

115611027(EVC)

ACUN:

113479256(EVC)

TALA:

104364377(EVC)

ACHC:

115339225(EVC)

HALD:

104310707(EVC)

HLE:	104841660(EVC)

AGEN:

126035737

GCL:

127015660

LDI:	104342795(EVC)

MNB:	103777128(EVC)

DPUB:

104303557(EVC)

AVIT:

104270411(EVC)

BRHI:

104498111(EVC)

EGZ:	104123276(EVC)

NNI:	104018035(EVC)

PCRI:

104023825

PCAO:

104052691(EVC)

PADL:

103921000(EVC)

AFOR:

103894401(EVC)

FGA:

104076654

CLV:	102089984(EVC)

MUI:	104542967(EVC)

PGUU:

104465100

PLET:

104625350(EVC)

EHS:	104515115(EVC)

CMAC:

104487502(EVC)

CUCA:

104062603(EVC)

BREG:

104634828

OHA:	104331095(EVC)

ACAR:

104517872(EVC)

CPEA:

104393630(EVC)

CVF:	104291335(EVC)

RTD:	128910100(EVC)

AAM:	106498769(EVC)

AROW:

112960504(EVC)

NPD:	112943002(EVC)

TGT:	104570254(EVC)

DNE:	112996480(EVC)

SCAM:

104151439(EVC)

ASN:	102378917(EVC)

AMJ:	102560015(EVC)

CPOO:

109322136(EVC)

GGN:	109303863(EVC)

PSS:	102458295(EVC)

CMY:	102948363(EVC)

CCAY:

125636181(EVC)

DCC:	119854672(EVC)

CPIC:

101948055(EVC)

TST:	117878015(EVC)

CABI:

116831748(EVC)

MRV:	120406868(EVC)

HCG:	128328226(EVC)

GJA:	107122650(EVC)

STOW:

125439765(EVC)

EMC:	129343647(EVC)

XLA:	108698025(evc.L)

XTR:	100124788(evc)

NPR:	108801820(EVC)

RTEM:

120924439(EVC)

BBUF:

120990358(EVC)

BGAR:

122929067(EVC)

MUO:	115461404(EVC)

GSH:	117362681(EVC)

SRX:	107716518(evc)

SANH:

107665621(evc)

SGH:	107575290(evc)

CAUA:

113058053(evc)

PTET:

LROH:

PPRM:

TROS:

TDW:

MANU:

IPU:

IFU:

PHYP:

113528305(evc)

SMEO:

TFD:

TVC:

TRN:

CMAO:

EEE:	113574012(evc)

TRU:	494347(evc)

TFS:

130524194

LCO:	104927933(evc)

NCC:	104961960(evc)

TBEN:

117486585

CGOB:

115008462(evc)

PGEO:

GACU:

EMAC:

ELY:

EFO:

PLEP:

SLUC:

ECRA:

ESP:	116687379(evc)

PFLV:

114554091(evc)

GAT:

PPUG:

AFB:

CLUM:

PSWI:

MSAM:

SCHU:

CUD:

ALAT:

MZE:	101477059(evc)

ONL:	100697930(evc)

OAU:

116326553

OLA:	101155188(evc)

OML:

112144827

CSAI:

133449494

XMA:	102237084(evc)

XCO:	114135906(evc)

XHE:	116710195(evc)

PRET:

103464958(evc)

PFOR:

103139547(evc)

PLAI:

106957342(evc)

PMEI:

106928896(evc)

GAF:

122834147

PPRL:

129358345

CVG:	107097281(evc)

CTUL:

119780115

GMU:

124856290

NFU:	107385513(evc)

KMR:

108239827

ALIM:

106518382(evc)

NWH:

119412234

MCEP:

125006544

CSEM:

103386251(evc)

POV:	109628933(evc)

SSEN:

HHIP:

HSP:

PPLT:

SMAU:

LCF:

SDU:	111221808(evc)

SLAL:

111648821 111670932(evc)

XGL:

120807106

HCQ:	109522679(evc)

SSCV:

SBIA:

PEE:

PTAO:

MALB:

109955927(evc)

BSPL:

114855528

SJO:

128355824

SASA:

106565206

STRU:

115208284(evc)

OTW:

112214299

OMY:

110493979

OGO:

124002674

ONE:	115142769(evc)

OKI:	109898666(evc)

OKE:

118389008

SALP:

111962444(evc)

SNH:

120021923

CCLU:

121575523

ELS:	105016756(evc)

SFM:	108924157(evc)

PKI:	111837698(evc)

AANG:

118230995

LOC:	102692603(evc)

PSPA:

121324688

ARUT:

117421162

LCM:	102351258(EVC)

CMK:

RTP:

CPLA:

HOC:

LERI:

BFO:

BBEL:

SPU:

LPIC:

APLC:

SKO:

PCAN:

GAE:

HRF:

HRJ:

MYI:

PMAX:

MMER:

LAK:	106157059 106179091

NVE:

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

Reference

PMID:25311364

Authors

Ginns EI, Galdzicka M, Elston RC, Song YE, Paul SM, Egeland JA

Title

Disruption of sonic hedgehog signaling in Ellis-van Creveld dwarfism confers protection against bipolar affective disorder.

Journal

Mol Psychiatry 20:1212-8 (2015)
DOI:10.1038/mp.2014.118

Reference

PMID:24582806

Authors

Pusapati GV, Hughes CE, Dorn KV, Zhang D, Sugianto P, Aravind L, Rohatgi R

Title

EFCAB7 and IQCE regulate hedgehog signaling by tethering the EVC-EVC2 complex to the base of primary cilia.

Journal

Dev Cell 28:483-96 (2014)
DOI:10.1016/j.devcel.2014.01.021

Sequence

[hsa:2121]

LinkDB

DBGET integrated database retrieval system