KEGG   ORTHOLOGY: K19647
Entry
K19647                      KO                                     
Symbol
hgd
Name
2-hydroxymethylglutarate dehydrogenase [EC:1.1.1.291]
Pathway
map00760  Nicotinate and nicotinamide metabolism
map01120  Microbial metabolism in diverse environments
Reaction
R07985  (S)-2-hydroxymethylglutarate:NAD+ oxidoreductase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00760 Nicotinate and nicotinamide metabolism
    K19647  hgd; 2-hydroxymethylglutarate dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.291  2-hydroxymethylglutarate dehydrogenase
     K19647  hgd; 2-hydroxymethylglutarate dehydrogenase
Other DBs
COG: COG2084
GO: 0043718
Genes
PPAV: LOZ86_04730
PAZZ: PBP221_57590
ADY: HLG70_00410
ACHM: V6V88_14645
ACHJ: LN047_14525
CTEZ: CT3_33160
ACUT: MRB58_12300
ASCA: QEZ52_21545
SNAP: PQ455_08180
STEL: STAQ_18560(mmsB)
SHUA: PQ477_20810
ALKL: MM271_17440
FEC: QNH15_18225
HYI: K2M58_02455
PROO: MJB10_03920
EFF: skT53_09660(mmsB)
CPAT: CLPA_c02850(hgd)
CPAE: CPAST_c02850(hgd)
ACOL: K5I23_11310
DOR: Desor_0451
TFR: BR63_08425
ACAE: HYG86_14495
PROM: QO263_18055
GEK: kuro4_03320(mmsB) kuro4_15860(garR) kuro4_16270
MHUI: MHLNE_21490(hgd)
NCJ: MCACP_23480(hgd)
TEP: TepRe1_0398
TAE: TepiRe1_0442(Hgd)
NTH: Nther_2161
STED: SPTER_39160(hgd)
SSPH: SPSPH_035210(hgd)
SOVA: SOV_13310(Hgd)
SSID: SPSIL_018550(hgd)
SACV: SPACI_025140(hgd)
SCAO: SCACP_04930(hgd_1) SCACP_05040(hgd_2) SCACP_29220(hgd_3)
SLUO: PS467_35950
KBB: ccbrp13_22740 ccbrp13_64320
IPO: Ilyop_0116
NAY: HYG81_23765
AG: ABC88394(hgd)
 » show all
Reference
PMID:16894175
  Authors
Alhapel A, Darley DJ, Wagener N, Eckel E, Elsner N, Pierik AJ.
  Title
Molecular and functional analysis of nicotinate catabolism in Eubacterium barkeri.
  Journal
Proc Natl Acad Sci U S A 103:12341-6 (2006)
DOI:10.1073/pnas.0601635103
  Sequence
[ag:ABC88394]
LinkDB

KEGG   ENZYME: 1.1.1.291
Entry
EC 1.1.1.291                Enzyme                                 
Name
2-hydroxymethylglutarate dehydrogenase;
HgD
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
(S)-2-hydroxymethylglutarate:NAD+ oxidoreductase
Reaction(IUBMB)
(S)-2-hydroxymethylglutarate + NAD+ = 2-formylglutarate + NADH + H+ [RN:R07985]
Reaction(KEGG)
R07985
Substrate
(S)-2-hydroxymethylglutarate;
NAD+ [CPD:C00003]
Product
2-formylglutarate [CPD:C16159];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
NADP+ cannot replace NAD+. Forms part of the nicotinate-fermentation catabolism pathway in Eubacterium barkeri. Other enzymes involved in this pathway are EC 1.17.1.5 (nicotinate dehydrogenase), EC 1.3.7.1 (6-hydroxynicotinate reductase), EC 3.5.2.18 (enamidase), EC 5.4.99.4 (2-methyleneglutarate mutase), EC 5.3.3.6 (methylitaconate Delta-isomerase), EC 4.2.1.85 (dimethylmaleate hydratase) and EC 4.1.3.32 (2,3-dimethylmalate lyase).
History
EC 1.1.1.291 created 2006
Pathway
ec00760  Nicotinate and nicotinamide metabolism
ec01120  Microbial metabolism in diverse environments
Orthology
K19647  2-hydroxymethylglutarate dehydrogenase
Genes
PPAV: LOZ86_04730
PAZZ: PBP221_57590
ADY: HLG70_00410
ACHM: V6V88_14645
ACHJ: LN047_14525
CTEZ: CT3_33160
ACUT: MRB58_12300
ASCA: QEZ52_21545
SNAP: PQ455_08180
STEL: STAQ_18560(mmsB)
SHUA: PQ477_20810
ALKL: MM271_17440
FEC: QNH15_18225
HYI: K2M58_02455
PROO: MJB10_03920
EFF: skT53_09660(mmsB)
CPAT: CLPA_c02850(hgd)
CPAE: CPAST_c02850(hgd)
ACOL: K5I23_11310
DOR: Desor_0451
TFR: BR63_08425
ACAE: HYG86_14495
PROM: QO263_18055
GEK: kuro4_03320(mmsB) kuro4_15860(garR) kuro4_16270
MHUI: MHLNE_21490(hgd)
NCJ: MCACP_23480(hgd)
TEP: TepRe1_0398
TAE: TepiRe1_0442(Hgd)
NTH: Nther_2161
STED: SPTER_39160(hgd)
SSPH: SPSPH_035210(hgd)
SOVA: SOV_13310(Hgd)
SSID: SPSIL_018550(hgd)
SACV: SPACI_025140(hgd)
SCAO: SCACP_04930(hgd_1) SCACP_05040(hgd_2) SCACP_29220(hgd_3)
SLUO: PS467_35950
KBB: ccbrp13_22740 ccbrp13_64320
IPO: Ilyop_0116
NAY: HYG81_23765
 » show all
Reference
1  [PMID:16894175]
  Authors
Alhapel A, Darley DJ, Wagener N, Eckel E, Elsner N, Pierik AJ.
  Title
Molecular and functional analysis of nicotinate catabolism in Eubacterium barkeri.
  Journal
Proc Natl Acad Sci U S A 103:12341-6 (2006)
DOI:10.1073/pnas.0601635103
  Sequence
[ag:ABC88394]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.291
IUBMB Enzyme Nomenclature: 1.1.1.291
ExPASy - ENZYME nomenclature database: 1.1.1.291
BRENDA, the Enzyme Database: 1.1.1.291
CAS: 1073478-76-8
LinkDB

KEGG   REACTION: R07985
Entry
R07985                      Reaction                               
Name
(S)-2-hydroxymethylglutarate:NAD+ oxidoreductase
Definition
2-Formylglutarate + NADH + H+ <=> (S)-2-(Hydroxymethyl)glutarate + NAD+
Equation
C16159 + C00004 + C00080 <=> C16390 + C00003
Reaction class
RC00001  C00003_C00004
RC00099  C16159_C16390
Enzyme
1.1.1.291
Pathway
rn00760  Nicotinate and nicotinamide metabolism
rn01120  Microbial metabolism in diverse environments
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.291
     R07985  2-Formylglutarate + NADH + H+ <=> (S)-2-(Hydroxymethyl)glutarate + NAD+
Orthology
K19647  2-hydroxymethylglutarate dehydrogenase [EC:1.1.1.291]
Reference
1  [PMID:16894175]
  Authors
Alhapel A, Darley DJ, Wagener N, Eckel E, Elsner N, Pierik AJ.
  Title
Molecular and functional analysis of nicotinate catabolism in Eubacterium barkeri.
  Journal
Proc Natl Acad Sci U S A 103:12341-6 (2006)
DOI:10.1073/pnas.0601635103
Other DBs
RHEA: 15508
LinkDB

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