KEGG ORTHOLOGY: K19742

ORTHOLOGY: K19742

Entry

K19742                      KO

Symbol

lhpI

Name

1-pyrroline-2-carboxylate reductase [NAD(P)H] [EC:1.5.1.49]

Pathway

map00330

Arginine and proline metabolism

map01100

Metabolic pathways

Reaction

R01246

L-proline:NAD+ 2-oxidoreductase

R01249

L-proline:NADP+ 2-oxidoreductase

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09105 Amino acid metabolism
   00330 Arginine and proline metabolism
    K19742  lhpI; 1-pyrroline-2-carboxylate reductase [NAD(P)H]
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.49  1-pyrroline-2-carboxylate reductase [NAD(P)H]
     K19742  lhpI; 1-pyrroline-2-carboxylate reductase [NAD(P)H]

Other DBs

COG:

COG2423

Genes

VPA:

VP1333

VPB:

VPBB_1257

VPK:	M636_15145

VPF:	M634_08575

VPH:	VPUCM_1890

VAG:

N646_0368

VEX:	VEA_003670

VDB:	AL552_14870

VHR:	AL538_01790

VOW:	A9237_01110

VCY:	IX92_23550

VCT:	JV59_16000

VTU:	IX91_17005

VEU:	IXK98_02510

VAF:	D1115_07875

VNL:	D3H41_06600

VIS:	VspSTUT16_18230

VIP:	H9L11_13485

SAZ:

SLO:

SSE:

SPL:

SHL:

SWD:

SWP:

SVO:

SPSW:

SMAV:

SALG:

SKH:	STH12_02499

SLIT:

SPSH:

SEUR:

SCYP:

SSEM:

SAEG:

SHAO:

SZH:	K0H63_14510

SSPA:

SHNS:

SRHS:

SHEM:

CPS:

COM:	CMT41_05485

LSD:	EMK97_00475

THAT:

H3N35_17485

TACT:

SG35_018505

TVD:	SG34_010795

PTN:	PTRA_b0312(ocd)

PSEO:

OM33_02120

PPHE:

PP2015_1743

PRR:	AT705_05440

PALN:

B0W48_16345

PPIS:

B1L02_08905

PSPO:

PSPO_a3016(ocd)

PTU:	PTUN_a0321(ocd)

PSEN:

PNC201_08170

PDJ:	D0907_20905

PVB:	J5X90_17030

PSAZ:

PFLI:

PMAZ:

PIN:

SAGA:

SLIO:

MME:	Marme_3477

MARD:

IBG28_18570

UPV:	EJN92_04875

UPI:	EJG51_008455

LAP:	ACP90_25405

LABR:

LABP:

LABT:

LAGG:

LUO:	HHL09_23025

» show all

Reference

PMID:24649405

Authors

Watanabe S, Tanimoto Y, Yamauchi S, Tozawa Y, Sawayama S, Watanabe Y

Title

Identification and characterization of trans-3-hydroxy-l-proline dehydratase and Delta(1)-pyrroline-2-carboxylate reductase involved in trans-3-hydroxy-l-proline metabolism of bacteria.

Journal

FEBS Open Bio 4:240-50 (2014)
DOI:10.1016/j.fob.2014.02.010

Sequence

[cps:CPS_1455]

LinkDB

ENZYME: 1.5.1.49

Entry

EC 1.5.1.49                 Enzyme

Name

1-pyrroline-2-carboxylate reductase [NAD(P)H]

Class

Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

L-proline:NAD(P)+ 2-oxidoreductase

Reaction(IUBMB)

L-proline + NAD(P)+ = 1-pyrroline-2-carboxylate + NAD(P)H + H+ [RN:R01246 R01249]

Reaction(KEGG)

R01246 R01249

Substrate

L-proline [CPD:C00148];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]

Product

1-pyrroline-2-carboxylate [CPD:C03564];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]

Comment

The enzyme from the bacterium Colwellia psychrerythraea is involved in trans-3-hydroxy-L-proline metabolism. In contrast to EC 1.5.1.1, 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H], which shows similar activity with 1-piperideine-2-carboxylate and 1-pyrroline-2-carboxylate, this enzyme is specific for the latter. While the enzyme is active with both NADH and NADPH, activity is higher with NADPH.

History

EC 1.5.1.49 created 2015

Pathway

ec00330

Arginine and proline metabolism

ec01100

Metabolic pathways

Orthology

K19742

1-pyrroline-2-carboxylate reductase [NAD(P)H]

Genes

VPA:

VP1333

VPB:

VPBB_1257

VPK:	M636_15145

VPF:	M634_08575

VPH:	VPUCM_1890

VAG:

N646_0368

VEX:	VEA_003670

VDB:	AL552_14870

VHR:	AL538_01790

VOW:	A9237_01110

VCY:	IX92_23550

VCT:	JV59_16000

VTU:	IX91_17005

VEU:	IXK98_02510

VAF:	D1115_07875

VNL:	D3H41_06600

VIS:	VspSTUT16_18230

VIP:	H9L11_13485

SAZ:

Sama_2610

SLO:

Shew_2955

SSE:

Ssed_3503

SPL:

Spea_3170

SHL:

Shal_3252

SWD:

Swoo_3726

SWP:

swp_3859

SVO:

SVI_3429

SPSW:

Sps_04403

SMAV:

CFF01_04500

SALG:

BS332_02430

SKH:	STH12_02499

SLIT:

JQC75_13605

SPSH:

FM037_06115

SEUR:

FM038_019110

SCYP:

JYB88_13395

SSEM:

JYB85_13715

SAEG:

K0H80_15145

SHAO:

K0H81_04795

SZH:	K0H63_14510

SSPA:

K0I31_15425

SHNS:

K0J45_15215

SRHS:

K0I63_15340

SHEM:

HWQ47_21045

CPS:

CPS_1455

COM:	CMT41_05485

LSD:	EMK97_00475

THAT:

H3N35_17485

TACT:

SG35_018505

TVD:	SG34_010795

PTN:	PTRA_b0312(ocd)

PSEO:

OM33_02120

PPHE:

PP2015_1743

PRR:	AT705_05440

PALN:

B0W48_16345

PPIS:

B1L02_08905

PSPO:

PSPO_a3016(ocd)

PTU:	PTUN_a0321(ocd)

PSEN:

PNC201_08170

PDJ:	D0907_20905

PVB:	J5X90_17030

PSAZ:

PA25_16800

PFLI:

CTT31_09500

PMAZ:

R5H13_10065

PIN:

Ping_2540

SAGA:

M5M_03795

SLIO:

R50072_20720

MME:	Marme_3477

MARD:

IBG28_18570

UPV:	EJN92_04875

UPI:	EJG51_008455

LAP:	ACP90_25405

LABR:

CHH27_22190

LABP:

FJ695_01495

LABT:

FIU93_03230

LAGG:

B0E33_08840

LUO:	HHL09_23025

» show all

Reference

1 [PMID:24649405]

Authors

Watanabe S, Tanimoto Y, Yamauchi S, Tozawa Y, Sawayama S, Watanabe Y

Title

Identification and characterization of trans-3-hydroxy-l-proline dehydratase and Delta(1)-pyrroline-2-carboxylate reductase involved in trans-3-hydroxy-l-proline metabolism of bacteria.

Journal

FEBS Open Bio 4:240-50 (2014)
DOI:10.1016/j.fob.2014.02.010

Sequence

[cps:CPS_1455]

Other DBs

ExplorEnz - The Enzyme Database:

1.5.1.49

IUBMB Enzyme Nomenclature:

1.5.1.49

ExPASy - ENZYME nomenclature database:

1.5.1.49

BRENDA, the Enzyme Database:

1.5.1.49

LinkDB

REACTION: R01246

Entry

R01246                      Reaction

Name

L-proline:NAD+ 2-oxidoreductase

Definition

L-Proline + NAD+ <=> 1-Pyrroline-2-carboxylate + NADH + H+

Equation

C00148 + C00003 <=> C03564 + C00004 + C00080

Comment

NADP+ (see R01249)

Reaction class

RC00001

C00003_C00004

RC00135

C00148_C03564

Enzyme

1.5.1.1 1.5.1.49

Pathway

rn00330

Arginine and proline metabolism

rn01100

Metabolic pathways

Brite

Enzymatic reactions [BR:br08201]
1. Oxidoreductase reactions
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.1
     R01246  L-Proline + NAD+ <=> 1-Pyrroline-2-carboxylate + NADH + H+
    1.5.1.49
     R01246  L-Proline + NAD+ <=> 1-Pyrroline-2-carboxylate + NADH + H+

Orthology

K19742

1-pyrroline-2-carboxylate reductase [NAD(P)H] [EC:1.5.1.49]

K19743

1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H] [EC:1.5.1.1]

Other DBs

RHEA:

20324

LinkDB

REACTION: R01249

Entry

R01249                      Reaction

Name

L-proline:NADP+ 2-oxidoreductase

Definition

L-Proline + NADP+ <=> 1-Pyrroline-2-carboxylate + NADPH + H+

Equation

C00148 + C00006 <=> C03564 + C00005 + C00080

Comment

NAD+ (see R01246)

Reaction class

RC00001

C00005_C00006

RC00135

C00148_C03564

Enzyme

1.5.1.1 1.5.1.21 1.5.1.49

Pathway

rn00330

Arginine and proline metabolism

rn01100

Metabolic pathways

Brite

Enzymatic reactions [BR:br08201]
1. Oxidoreductase reactions
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.1
     R01249  L-Proline + NADP+ <=> 1-Pyrroline-2-carboxylate + NADPH + H+
    1.5.1.21
     R01249  L-Proline + NADP+ <=> 1-Pyrroline-2-carboxylate + NADPH + H+
    1.5.1.49
     R01249  L-Proline + NADP+ <=> 1-Pyrroline-2-carboxylate + NADPH + H+

Orthology

K19742

1-pyrroline-2-carboxylate reductase [NAD(P)H] [EC:1.5.1.49]

K19743

1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H] [EC:1.5.1.1]

Other DBs

RHEA:

20320

LinkDB

DBGET integrated database retrieval system