lhpI

PMID:24649405

lhpI

PMID:24649405

Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy

L-pipecolate/L-proline:NAD(P)+ 2-oxidoreductase

(1) L-pipecolate + NAD(P)+ = 1-piperideine-2-carboxylate + NAD(P)H + H+ [RN:R02201 R02203];
(2) L-proline + NAD(P)+ = 1-pyrroline-2-carboxylate + NAD(P)H + H+ [RN:R01246 R01249]

R01246 R01249 R02201 R02203
Reaction

L-pipecolate [CPD:C00408];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006];
L-proline [CPD:C00148]

The enzymes, characterized from the bacterium Azospirillum brasilense, is involved in trans-3-hydroxy-L-proline metabolism. In contrast to EC 1.5.1.21, 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase (NADPH), which is specific for NADPH, this enzyme shows similar activity with NADPH and NADH.

EC 1.5.1.1 created 1961, modified 2015

1  [PMID:13502341]

2  [PMID:24649405]

Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy

L-proline:NAD(P)+ 2-oxidoreductase

L-proline + NAD(P)+ = 1-pyrroline-2-carboxylate + NAD(P)H + H+ [RN:R01246 R01249]

R01246 R01249
Reaction

L-proline [CPD:C00148];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]

The enzyme from the bacterium Colwellia psychrerythraea is involved in trans-3-hydroxy-L-proline metabolism. In contrast to EC 1.5.1.1, 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H], which shows similar activity with 1-piperideine-2-carboxylate and 1-pyrroline-2-carboxylate, this enzyme is specific for the latter. While the enzyme is active with both NADH and NADPH, activity is higher with NADPH.

EC 1.5.1.49 created 2015

1  [PMID:24649405]

C00148 + C00003 <=> C03564 + C00004 + C00080

NADP+ (see R01249)

1.5.1.1         1.5.1.49

C00148 + C00006 <=> C03564 + C00005 + C00080

NAD+ (see R01246)

1.5.1.1         1.5.1.21        1.5.1.49