KEGG   ORTHOLOGY: K19743
Entry
K19743                      KO                                     
Symbol
lhpI
Name
1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H] [EC:1.5.1.1]
Pathway
map00310  Lysine degradation
map00330  Arginine and proline metabolism
map00960  Tropane, piperidine and pyridine alkaloid biosynthesis
map01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00310 Lysine degradation
    K19743  lhpI; 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H]
   00330 Arginine and proline metabolism
    K19743  lhpI; 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H]
  09110 Biosynthesis of other secondary metabolites
   00960 Tropane, piperidine and pyridine alkaloid biosynthesis
    K19743  lhpI; 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H]
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.1  1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H]
     K19743  lhpI; 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H]
Other DBs
RN: R01246 R01249 R02201 R02203
COG: COG2423
GO: 0050241
Genes
BGJ: AWC36_18660
BIZ: HC231_23665
LBQ: CKQ53_13775
SOD: Sant_2254
PAZO: AYR47_02320
PCH: EY04_18125
PSES: PSCI_5175
PSIL: PMA3_09465
SPIU: SPICUR_00995
SROS: BBH56_00065
PSE: NH8B_0270
AMAH: DLM_1509
RSO: RSc3352
RSE: F504_3400
RSY: RSUY_01390(rapL_1)
RPI: Rpic_3546
REH: H16_A3673(h16_A3673)
RME: Rmet_3527
CGD: CR3_2832
BMA: BMAA1290
BMAL: DM55_4233
BMAE: DM78_3939
BMAQ: DM76_4933
BMAI: DM57_10585
BMAF: DM51_4945
BMAZ: BM44_4196
BMAB: BM45_3318
BPS: BPSS0940
BPSE: BDL_4230
BPSM: BBQ_5196
BPSU: BBN_4400
BPSD: BBX_6071
BPK: BBK_3495
BPSH: DR55_4394
BPSA: BBU_5089
BPSO: X996_4178
BUT: X994_6182
BTQ: BTQ_4743
BTJ: BTJ_5685
BTZ: BTL_4224
BTD: BTI_5755
BTV: BTHA_3733
BTHE: BTN_3467
BTHM: BTRA_4218
BTHA: DR62_3540
BTHL: BG87_4200
BOK: DM82_5110
BOC: BG90_5484
BSAV: WS86_23435
BVE: AK36_4029
BCN: Bcen_4010
BCJ: BCAM1485
BCEN: DM39_3532
BCEW: DM40_4351
BCEO: I35_5339
BAM: Bamb_3766
BMJ: BMULJ_04243(ocd)
BMU: Bmul_4263
BMK: DM80_3437
BMUL: NP80_4355
BCT: GEM_4275
BCED: DM42_3604
BDL: AK34_4045
BCON: NL30_05175
BUB: BW23_5154
BLAT: WK25_24125
BTEI: WS51_05030
BSEM: WJ12_27260
BPSL: WS57_06730
BMEC: WJ16_25790
BSTG: WT74_26205
BGU: KS03_5219
BGO: BM43_4860
BUK: MYA_4327
BUL: BW21_5442
BXE: Bxe_B1765
BXB: DR64_7069
BPH: Bphy_3343
BFN: OI25_4196
PDIO: PDMSB3_1300.1(lhpI)
PPNO: DA70_16420
PPNM: LV28_14325
PPUL: RO07_08380
PSPU: NA29_04175
PAPI: SG18_08825
CABA: SBC2_64960(ocd_1)
AMIM: MIM_c39830
BPSI: IX83_00760
AFQ: AFA_14940
ODI: ODI_R1977
PVAC: HC248_02698(ocd_2)
AAV: Aave_3400
AAA: Acav_1835
ACRA: BSY15_502
VEI: Veis_1338
DAC: Daci_2152
CTES: O987_21445
RTA: Rta_32100
HYR: BSY239_30
HYB: Q5W_19710
MPT: Mpe_A1509
CFU: CFU_3543
CARE: LT85_4058
NET: Neut_2213
DFL: DFE_1833
DMA: DMR_28030(ocd)
DGG: DGI_1547
ZMO: ZMO1975
ZMN: Za10_1195
ZMB: ZZ6_1206
ZMI: ZCP4_1234
GOH: B932_1581
GXL: H845_2323
ASZ: ASN_1466(ocd)
AZL: AZL_d02350(ocd)
RXY: Rxyl_2927
TRA: Trad_0061
MRB: Mrub_0429
 » show all
Reference
  Authors
Watanabe S, Tanimoto Y, Yamauchi S, Tozawa Y, Sawayama S, Watanabe Y
  Title
Identification and characterization of trans-3-hydroxy-l-proline dehydratase and Delta(1)-pyrroline-2-carboxylate reductase involved in trans-3-hydroxy-l-proline metabolism of bacteria.
  Journal
FEBS Open Bio 4:240-50 (2014)
DOI:10.1016/j.fob.2014.02.010
  Sequence
LinkDB

KEGG   ORTHOLOGY: K19742
Entry
K19742                      KO                                     
Symbol
lhpI
Name
1-pyrroline-2-carboxylate reductase [NAD(P)H] [EC:1.5.1.49]
Pathway
map00330  Arginine and proline metabolism
map01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00330 Arginine and proline metabolism
    K19742  lhpI; 1-pyrroline-2-carboxylate reductase [NAD(P)H]
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.49  1-pyrroline-2-carboxylate reductase [NAD(P)H]
     K19742  lhpI; 1-pyrroline-2-carboxylate reductase [NAD(P)H]
Other DBs
RN: R01246 R01249
COG: COG2423
Genes
VPA: VP1333
VPB: VPBB_1257
VPK: M636_15145
VPF: M634_08575
VPH: VPUCM_1890
VAG: N646_0368
VEX: VEA_003670
VDB: AL552_14870
VHR: AL538_01790
VOW: A9237_01110
SAZ: Sama_2610
SLO: Shew_2955
SSE: Ssed_3503
SPL: Spea_3170
SHL: Shal_3252
SWD: Swoo_3726
SWP: swp_3859
SVO: SVI_3429
SPSW: Sps_04403
CPS: CPS_1455
PTN: PTRA_b0312(ocd)
PSEO: OM33_02120
PSPO: PSPO_a3016(ocd)
PTU: PTUN_a0321(ocd)
PSAZ: PA25_16800
PIN: Ping_2540
SAGA: M5M_03795
 » show all
Reference
  Authors
Watanabe S, Tanimoto Y, Yamauchi S, Tozawa Y, Sawayama S, Watanabe Y
  Title
Identification and characterization of trans-3-hydroxy-l-proline dehydratase and Delta(1)-pyrroline-2-carboxylate reductase involved in trans-3-hydroxy-l-proline metabolism of bacteria.
  Journal
FEBS Open Bio 4:240-50 (2014)
DOI:10.1016/j.fob.2014.02.010
  Sequence
[cps:CPS_1455]
LinkDB

KEGG   ENZYME: 1.5.1.1
Entry
EC 1.5.1.1                  Enzyme                                 
Name
1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H];
Delta1-pyrroline-2-carboxylate reductase;
DELTA1-pyrroline-2-carboxylate reductase;
DELTA1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase (ambiguous);
AbLhpI;
pyrroline-2-carboxylate reductase;
L-proline:NAD(P)+ 2-oxidoreductase
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
L-pipecolate/L-proline:NAD(P)+ 2-oxidoreductase
Reaction(IUBMB)
(1) L-pipecolate + NAD(P)+ = 1-piperideine-2-carboxylate + NAD(P)H + H+ [RN:R02201 R02203];
(2) L-proline + NAD(P)+ = 1-pyrroline-2-carboxylate + NAD(P)H + H+ [RN:R01246 R01249]
Reaction(KEGG)
Substrate
L-pipecolate [CPD:C00408];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006];
L-proline [CPD:C00148]
Product
1-piperideine-2-carboxylate [CPD:C04092];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080];
1-pyrroline-2-carboxylate [CPD:C03564]
Comment
The enzymes, characterized from the bacterium Azospirillum brasilense, is involved in trans-3-hydroxy-L-proline metabolism. In contrast to EC 1.5.1.21, 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase (NADPH), which is specific for NADPH, this enzyme shows similar activity with NADPH and NADH.
History
EC 1.5.1.1 created 1961, modified 2015
Pathway
ec00310  Lysine degradation
ec00330  Arginine and proline metabolism
ec00960  Tropane, piperidine and pyridine alkaloid biosynthesis
ec01100  Metabolic pathways
Orthology
K19743  1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H]
Genes
BGJAWC36_18660
BIZHC231_23665
LBQCKQ53_13775
SODSant_2254
PAZOAYR47_02320
PCHEY04_18125
PSESPSCI_5175
PSILPMA3_09465
SPIUSPICUR_00995
SROSBBH56_00065
PSENH8B_0270
AMAHDLM_1509
RSORSc3352
RSCRCFBP_10114
RSLRPSI07_0093
RSNRSPO_c00089
RSMCMR15_10116
RSEF504_3400
RSYRSUY_01390(rapL_1)
RPIRpic_3546
RPFRpic12D_3222
RPJN234_20505
RMNTK49_02570
RINACS15_3655
RPUCDC45_17140
REHH16_A3673(h16_A3673)
CNCCNE_1c36230
CUHBJN34_19590
REUReut_A3381
RMERmet_3527
CTIRALTA_A3129
CBWRR42_m4138
CGDCR3_2832
CCUPBKK81_01450
CUPBKK80_00785
CUUBKK79_11375
CPAUEHF44_05820
COXE0W60_27530
BMABMAA1290
BMVBMASAVP1_0266
BMLBMA10229_0536
BMNBMA10247_A1031
BMALDM55_4233
BMAEDM78_3939
BMAQDM76_4933
BMAIDM57_10585
BMAFDM51_4945
BMAZBM44_4196
BMABBM45_3318
BPSBPSS0940
BPMBURPS1710b_A2543
BPLBURPS1106A_A1291
BPDBURPS668_A1371
BPSEBDL_4230
BPSMBBQ_5196
BPSUBBN_4400
BPSDBBX_6071
BPZBP1026B_II1030
BPQBPC006_II1306
BPKBBK_3495
BPSHDR55_4394
BPSABBU_5089
BPSOX996_4178
BUTX994_6182
BTEBTH_II1457
BTQBTQ_4743
BTJBTJ_5685
BTZBTL_4224
BTDBTI_5755
BTVBTHA_3733
BTHEBTN_3467
BTHMBTRA_4218
BTHADR62_3540
BTHLBG87_4200
BOKDM82_5110
BOCBG90_5484
BUUWS70_22180
BSAVWS86_23435
BVIBcep1808_4889 Bcep1808_6676
BVEAK36_4029
BURBcep18194_B1663
BCNBcen_4010
BCHBcen2424_4357
BCMBcenmc03_5997
BCJBCAM1485
BCENDM39_3532
BCEWDM40_4351
BCEOI35_5339
BAMBamb_3766
BACBamMC406_4240
BMJBMULJ_04243(ocd)
BMUBmul_4263
BMKDM80_3437
BMULNP80_4355
BCTGEM_4275
BCEDDM42_3604
BCEPAPZ15_32020
BDLAK34_4045
BPYRABD05_28725
BCONNL30_05175
BUBBW23_5154
BDFWI26_20365
BLATWK25_24125
BTEIWS51_05030
BSEMWJ12_27260
BPSLWS57_06730
BMECWJ16_25790
BSTGWT74_26205
BSTLBBJ41_20490
BANNJFN94_24455
BGLbglu_2g07030
BGUKS03_5219
BUGBC1001_5631
BGFBC1003_5729
BGDbgla_2g12060
BGOBM43_4860
BYIBYI23_B003960 BYI23_C005280
BUKMYA_4327
BUEBRPE67_BCDS06550 BRPE67_CCDS06230
BULBW21_5442
BUQAC233_30570
BGPBGL_2c21310
BPLAbpln_2g21410
BUDAQ610_25980
BUMAXG89_39245
BUIAX768_21115
BURKDM992_18470
BXEBxe_B1765
BXBDR64_7069
BPHBphy_3343
BGEBC1002_3728
BPXBUPH_06129
BPYBphyt_4907
BUZAYM40_24630
BFNOI25_4196
BCAIK788_0008493
PSPWBJG93_16945 BJG93_30575
PARABTO02_28190
PARBCJU94_20935
PHSC2L64_27315
PTERC2L65_21185
PGPCUJ91_25630 CUJ91_31175
PCJCUJ87_19665
PTSCUJ90_18630
PCAFDSC91_001681
PMEGFNZ07_10020
PGISI6I06_21310
PACPFAZ97_20335
PEWKZJ38_30745
PDIOPDMSB3_1300.1(lhpI)
PPKU875_23685
PPNODA70_16420
PPNMLV28_14325
PRBX636_10455
PPULRO07_08380
PSPUNA29_04175
PAPISG18_08825
PVEUC34_24400
POXMB84_04495
PTXABW99_16995
PFGAB870_11355
PNRAT302_07940
PANDDRB87_22880
PFIBPI93_024530
CABASBC2_64960(ocd_1)
BUOBRPE64_BCDS09290
AKATKWG_24615
AMIMMIM_c39830
CDNBN940_16136
BPSIIX83_00760
AFAUZ73_14790
AFQAFA_14940
AAQUD3M96_15870
AAMMFE795_13800
PHNPAEH1_12825
ODIODI_R1977
PARKLSG25_19450
RHFEUB48_17055
POSDT070_01085
POOF7R28_08365
PVACHC248_02698(ocd_2)
AAVAave_3400
AAAAcav_1835
ACKC380_05510
ACRABSY15_502
ACIDCBP33_04675
ACIPCBP36_05100
ACINCBP34_04635
ACISCBP35_13835
AMONH9L24_20900
VEIVeis_1338
DACDaci_2152
DELDelCs14_4535
DTSBI380_13765
DHKBO996_10010
DLAI6G47_13785
CTTCtCNB1_3667
CTESO987_21445
CKEB5M06_09815
COFFOZ74_12640
RTARta_32100
OTKC6570_17210
HYRBSY239_30
HYBQ5W_19710
KIAG8A07_07865
MPTMpe_A1509
METPC1M51_00665
HSEHsero_0176
HSZACP92_00875
HHTF506_21360
HRBHrubri_0191
HEEhmeg3_22520
HHFE2K99_01140
HFRG5S34_00880
CFUCFU_3543
CARELT85_4058
CPRACPter91_4367
MPLIE1742_14480
NOKFAY22_03770
GLCJQN73_04585
RDPRD2015_1338
PKTAT984_14370
MIUABE85_00125
TTWLCC91_00420
NETNeut_2213
DFLDFE_1833
DSDGD606_02995
DMADMR_28030(ocd)
DCBC3Y92_12855
DGGDGI_1547
DAFDesaf_2510
DSXGD604_10005
ZMOZMO1975
ZMNZa10_1195
ZMBZZ6_1206
ZMIZCP4_1234
ZMCA265_01223
ZMRA254_01222
GOHB932_1581
GALA0U94_09505
GTIFXF46_03430
GFAMKW11_03325
GXLH845_2323
KNAB0W47_06280
KEUS101446_01615
KSCCD178_02861
APTAPA01_08140
APWAPA42C_08140
APFAPA03_08140
APUAPA07_08140
APGAPA12_08140
APQAPA22_08140
APXAPA26_08140
APZAPA32_08140
APKAPA386B_2319
ASZASN_1466(ocd)
ASVWG31_04555
APOMCPF11_03415
ATOCIW82_00155 CIW82_04965
AASCA4S02_02110
ACETDS739_04260
AOYEOV40_003815
NCHA0U93_11420
KHAIFJ82_02935
AZLAZL_d02350(ocd)
ALIAZOLI_p40331
ATIAL072_25090
AZMDM194_22605
AOZHUE56_04635
RXYRxyl_2927
RUBGBA63_16515
RMARGBA65_08750
DDRDeide_3p02181
TRATrad_0061
TANTKNN15_12430
MRBMrub_0429
MREK649_01770
MSVMesil_1519
MTAIMtai_v1c03530
OPROcepr_1284
MHDMarky_1461
 » show all
Reference
1  [PMID:13502341]
  Authors
MEISTER A, RADHAKRISHNAN AN, BUCKLEY SD.
  Title
Enzymatic synthesis of L-pipecolic acid and L-proline.
  Journal
J Biol Chem 229:789-800 (1957)
Reference
2  [PMID:24649405]
  Authors
Watanabe S, Tanimoto Y, Yamauchi S, Tozawa Y, Sawayama S, Watanabe Y
  Title
Identification and characterization of trans-3-hydroxy-l-proline dehydratase and Delta(1)-pyrroline-2-carboxylate reductase involved in trans-3-hydroxy-l-proline metabolism of bacteria.
  Journal
FEBS Open Bio 4:240-50 (2014)
DOI:10.1016/j.fob.2014.02.010
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.5.1.1
IUBMB Enzyme Nomenclature: 1.5.1.1
ExPASy - ENZYME nomenclature database: 1.5.1.1
BRENDA, the Enzyme Database: 1.5.1.1
CAS: 9029-16-7
LinkDB

KEGG   ENZYME: 1.5.1.49
Entry
EC 1.5.1.49                 Enzyme                                 
Name
1-pyrroline-2-carboxylate reductase [NAD(P)H]
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
L-proline:NAD(P)+ 2-oxidoreductase
Reaction(IUBMB)
L-proline + NAD(P)+ = 1-pyrroline-2-carboxylate + NAD(P)H + H+ [RN:R01246 R01249]
Reaction(KEGG)
R01246 R01249
Substrate
L-proline [CPD:C00148];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
1-pyrroline-2-carboxylate [CPD:C03564];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme from the bacterium Colwellia psychrerythraea is involved in trans-3-hydroxy-L-proline metabolism. In contrast to EC 1.5.1.1, 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H], which shows similar activity with 1-piperideine-2-carboxylate and 1-pyrroline-2-carboxylate, this enzyme is specific for the latter. While the enzyme is active with both NADH and NADPH, activity is higher with NADPH.
History
EC 1.5.1.49 created 2015
Pathway
ec00330  Arginine and proline metabolism
ec01100  Metabolic pathways
Orthology
K19742  1-pyrroline-2-carboxylate reductase [NAD(P)H]
Genes
VPAVP1333
VPBVPBB_1257
VPKM636_15145
VPFM634_08575
VPHVPUCM_1890
VAGN646_0368
VEXVEA_003670
VDBAL552_14870
VHRAL538_01790
VOWA9237_01110
VCYIX92_23550
VCTJV59_16000
VTUIX91_17005
VEUIXK98_02510
VAFD1115_07875
VNLD3H41_06600
SAZSama_2610
SLOShew_2955
SSESsed_3503
SPLSpea_3170
SHLShal_3252
SWDSwoo_3726
SWPswp_3859
SVOSVI_3429
SPSWSps_04403
SMAVCFF01_04500
SALGBS332_02430
SKHSTH12_02499
SLITJQC75_13605
SPSHFM037_06115
SEURFM038_019110
SCYPJYB88_13395
SSEMJYB85_13715
CPSCPS_1455
COMCMT41_05485
LSDEMK97_00475
PTNPTRA_b0312(ocd)
PSEOOM33_02120
PPHEPP2015_1743
PRRAT705_05440
PALNB0W48_16345
PPISB1L02_08905
PSPOPSPO_a3016(ocd)
PTUPTUN_a0321(ocd)
PSENPNC201_08170
PDJD0907_20905
PVBJ5X90_17030
PSAZPA25_16800
PINPing_2540
SAGAM5M_03795
MMEMarme_3477
MARDIBG28_18570
UPVEJN92_04875
UPIEJG51_008455
LAPACP90_25405
LABRCHH27_22190
LABPFJ695_01495
LABTFIU93_03230
LAGGB0E33_08840
LUOHHL09_23025
 » show all
Reference
1  [PMID:24649405]
  Authors
Watanabe S, Tanimoto Y, Yamauchi S, Tozawa Y, Sawayama S, Watanabe Y
  Title
Identification and characterization of trans-3-hydroxy-l-proline dehydratase and Delta(1)-pyrroline-2-carboxylate reductase involved in trans-3-hydroxy-l-proline metabolism of bacteria.
  Journal
FEBS Open Bio 4:240-50 (2014)
DOI:10.1016/j.fob.2014.02.010
  Sequence
[cps:CPS_1455]
Other DBs
ExplorEnz - The Enzyme Database: 1.5.1.49
IUBMB Enzyme Nomenclature: 1.5.1.49
ExPASy - ENZYME nomenclature database: 1.5.1.49
BRENDA, the Enzyme Database: 1.5.1.49
LinkDB

KEGG   REACTION: R01246
Entry
R01246                      Reaction                               
Name
L-proline:NAD+ 2-oxidoreductase
Definition
L-Proline + NAD+ <=> 1-Pyrroline-2-carboxylate + NADH + H+
Equation
Comment
NADP+ (see R01249)
Reaction class
RC00001  C00003_C00004
RC00135  C00148_C03564
Enzyme
1.5.1.1         1.5.1.49
Pathway
rn00330  Arginine and proline metabolism
rn01100  Metabolic pathways
Orthology
K19742  1-pyrroline-2-carboxylate reductase [NAD(P)H] [EC:1.5.1.49]
K19743  1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H] [EC:1.5.1.1]
Other DBs
RHEA: 20324
LinkDB

KEGG   REACTION: R01249
Entry
R01249                      Reaction                               
Name
L-proline:NADP+ 2-oxidoreductase
Definition
L-Proline + NADP+ <=> 1-Pyrroline-2-carboxylate + NADPH + H+
Equation
Comment
NAD+ (see R01246)
Reaction class
RC00001  C00005_C00006
RC00135  C00148_C03564
Enzyme
1.5.1.1         1.5.1.21        1.5.1.49
Pathway
rn00330  Arginine and proline metabolism
rn01100  Metabolic pathways
Orthology
K19742  1-pyrroline-2-carboxylate reductase [NAD(P)H] [EC:1.5.1.49]
K19743  1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H] [EC:1.5.1.1]
Other DBs
RHEA: 20320
LinkDB

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