KEGG   ORTHOLOGY: K20508
Entry
K20508            Tight     KO                                     
Symbol
OAC
Name
olivetolic acid cyclase [EC:4.4.1.26]
Pathway
map00999  Biosynthesis of various plant secondary metabolites
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00894  Cannabidiol biosynthesis, malonyl-CoA => cannabidiol/dronabinol
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00999 Biosynthesis of various plant secondary metabolites
    K20508  OAC; olivetolic acid cyclase
Enzymes [BR:ko01000]
 4. Lyases
  4.4  Carbon-sulfur lyases
   4.4.1  Carbon-sulfur lyases (only sub-subclass identified to date)
    4.4.1.26  olivetolic acid cyclase
     K20508  OAC; olivetolic acid cyclase
Other DBs
RN: R10278
Genes
AG: AFN42527(OAC)
Reference
  Authors
Gagne SJ, Stout JM, Liu E, Boubakir Z, Clark SM, Page JE
  Title
Identification of olivetolic acid cyclase from Cannabis sativa reveals a unique catalytic route to plant polyketides.
  Journal
Proc Natl Acad Sci U S A 109:12811-6 (2012)
DOI:10.1073/pnas.1200330109
  Sequence
LinkDB

KEGG   ENZYME: 4.4.1.26
Entry
EC 4.4.1.26                 Enzyme                                 
Name
olivetolic acid cyclase;
OAC
Class
Lyases;
Carbon-sulfur lyases;
Carbon-sulfur lyases (only sub-subclass identified to date)
Sysname
3,5,7-trioxododecanoyl-CoA CoA-lyase (2,4-dihydroxy-6-pentylbenzoate-forming)
Reaction(IUBMB)
3,5,7-trioxododecanoyl-CoA = CoA + 2,4-dihydroxy-6-pentylbenzoate [RN:R10278]
Reaction(KEGG)
R10278
Substrate
3,5,7-trioxododecanoyl-CoA [CPD:C20413]
Product
CoA [CPD:C00010];
2,4-dihydroxy-6-pentylbenzoate [CPD:C20417]
Comment
Part of the cannabinoids biosynthetic pathway in the plant Cannabis sativa.
History
EC 4.4.1.26 created 2012
Pathway
ec00999  Biosynthesis of various plant secondary metabolites
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K20508  olivetolic acid cyclase
Reference
1  [PMID:22802619]
  Authors
Gagne SJ, Stout JM, Liu E, Boubakir Z, Clark SM, Page JE
  Title
Identification of olivetolic acid cyclase from Cannabis sativa reveals a unique catalytic route to plant polyketides.
  Journal
Proc Natl Acad Sci U S A 109:12811-6 (2012)
DOI:10.1073/pnas.1200330109
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.4.1.26
IUBMB Enzyme Nomenclature: 4.4.1.26
ExPASy - ENZYME nomenclature database: 4.4.1.26
BRENDA, the Enzyme Database: 4.4.1.26
LinkDB

KEGG   REACTION: R10278
Entry
R10278                      Reaction                               
Name
3,5,7-trioxododecanoyl-CoA CoA-lyase (2,4-dihydroxy-6-pentylbenzoate-forming)
Definition
3,5,7-Trioxododecanoyl-CoA <=> CoA + 2,4-Dihydroxy-6-pentylbenzoate
Equation
Reaction class
RC00004  C00010_C20413
RC03104  C20413_C20417
Enzyme
Pathway
rn00999  Biosynthesis of various plant secondary metabolites
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00894  Cannabidiol biosynthesis, malonyl-CoA => cannabidiol/dronabinol
Orthology
K20508  olivetolic acid cyclase [EC:4.4.1.26]
Other DBs
RHEA: 34126
LinkDB

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