KEGG   ORTHOLOGY: K21255
Entry
K21255                      KO                                     
Symbol
calO6
Name
orsellinic acid C2-O-methyltransferase [EC:2.1.1.-]
Pathway
map01059  Biosynthesis of enediyne antibiotics
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00833  Calicheamicin biosynthesis, calicheamicinone => calicheamicin
M00834  Calicheamicin orsellinate moiety biosynthesis, malonyl-CoA => orsellinate-ACP => 5-iodo-2,3-dimethoxyorsellinate-ACP
Reaction
R11413  S-adenosyl-L-methionine:orsellinate-[acp] O-methyltransferase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01059 Biosynthesis of enediyne antibiotics
    K21255  calO6; orsellinic acid C2-O-methyltransferase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K21255  calO6; orsellinic acid C2-O-methyltransferase
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide tailoring proteins
  Methylase
   K21255  calO6; orsellinic acid C2-O-methyltransferase
Genes
SCIR: STRCI_006242
AMAZ: LUW76_47505
PSDS: K1T35_21960
KUT: JJ691_29910
ACTU: Actkin_02983(tcmN_3)
SAQ: Sare_2028
AG: AAM70356(calO6)
Reference
  Authors
Ahlert J, Shepard E, Lomovskaya N, Zazopoulos E, Staffa A, Bachmann BO, Huang K, Fonstein L, Czisny A, Whitwam RE, Farnet CM, Thorson JS
  Title
The calicheamicin gene cluster and its iterative type I enediyne PKS.
  Journal
Science 297:1173-6 (2002)
DOI:10.1126/science.1072105
  Sequence
Reference
  Authors
Singh S, Nandurkar NS, Thorson JS
  Title
Characterization of the calicheamicin orsellinate C2-O-methyltransferase CalO6.
  Journal
Chembiochem 15:1418-21 (2014)
DOI:10.1002/cbic.201402119
LinkDB

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