KEGG ORTHOLOGY: K21273

ORTHOLOGY: K21273

Entry

K21273                      KO

Symbol

E2.5.1.88

Name

trans,polycis-polyprenyl diphosphate synthase [EC:2.5.1.88]

Pathway

map00900

Terpenoid backbone biosynthesis

map01110

Biosynthesis of secondary metabolites

Reaction

R09731

(2Z,6E)-farnesyl-diphosphate:isopentenyl-diphosphate cistransferase (adding 9-11 isopentenyl units)

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00900 Terpenoid backbone biosynthesis
    K21273  E2.5.1.88; trans,polycis-polyprenyl diphosphate synthase
Enzymes [BR:ko01000]
2. Transferases
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.88  trans,polycis-polyprenyl diphosphate synthase [(2Z,6E)-farnesyl diphosphate specific]
     K21273  E2.5.1.88; trans,polycis-polyprenyl diphosphate synthase

Other DBs

COG:

COG0020

Genes

SHAU:

K9S39_00850(uppS)

MLY:	CJ228_003870

PALU:

CJ193_000905

PHW:	G7075_08440

BLUT:

EW640_02245

BCAU:

I6G59_13875

AUS:	IPK37_16425

PAUS:

NCTC13651_01488(uppS)

PRV:	G7070_00365

BRT:	J4N02_06640

PSOI:

PCC79_06620

KFL:

Kfla_2449

KQI:	F1D05_32195

TFU:

THAO:

TALX:

NDA:

NGV:	CDO52_20120

NEX:	NE857_10750

NEC:	KGD82_19315

NAKE:

KGD83_22070

NCG:	KGD84_23705

STRR:

SNAH:

SAIU:

TCU:

ACTW:

AGRA:

AMAZ:

ACIR:

SPIQ:

ACTQ:

SRO:

NOA:	BKM31_32885

NOW:	GBF35_11800

NCX:	Nocox_11025

NGN:	LCN96_12435

NFS:	OIE67_34555

TBI:

Tbis_1177

MHAI:

OHB01_22425

STP:	Strop_3446

SAQ:

Sare_3825

MAU:	Micau_4838

MIL:

MICB:

MTUA:

MICH:

MTEM:

MCAB:

MSAG:

GCM10017556_10970(uppS1)

VMA:	VAB18032_28301

MCRA:

ID554_22120

VER:	HUT12_29105

MENO:

Jiend_42340(uppS1)

MCHL:

MFEU:

MPRN:

MHAW:

MCAY:

MICF:

ASE:

AMS:	AMIS_11890

ACTN:

L083_1597

ACTS:

ACWT_1300

AIH:	Aiant_56320(uppS1)

ACTR:

Asp14428_30000(uppS1)

ACTL:

L3i22_013320(uppS)

ASIC:

Q0Z83_075810

AOU:	ACTOB_001303

ACTE:

ACTI_32740(uppS_2)

AFS:

AFR_08000

PLK:	CIK06_21945

PLAB:

C6361_31565

PLAT:

C6W10_34995

PFLA:

Pflav_057510(uppS1)

PSUU:

Psuf_017140(uppS1)

ATL:	Athai_13260(uppS_2)

ASER:

Asera_60570(uppS1)

PRY:	Prubr_07990(uppS1)

CATI:

CS0771_00170(uppS1)

DVC:	Dvina_46555

DFU:	Dfulv_40965

DROS:

DAUR:

DMAT:

DACT:

NHY:	JQS43_07375

CCAZ:

COUCH_31645

SNA:

Snas_2041

NAV:	JQS30_11505

GLY:	K3N28_04635

» show all

Reference

PMID:19447338

Authors

Ambo T, Noike M, Kurokawa H, Koyama T

Title

Cloning and functional analysis of cis-prenyltransferase from Thermobifida fusca.

Journal

J Biosci Bioeng 107:620-2 (2009)
DOI:10.1016/j.jbiosc.2009.02.006

Sequence

[tfu:Tfu_0853]

LinkDB

ENZYME: 2.5.1.88

Entry

EC 2.5.1.88                 Enzyme

Name

trans,polycis-polyprenyl diphosphate synthase [(2Z,6E)-farnesyl diphosphate specific]

Class

Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

Sysname

(2Z,6E)-farnesyl-diphosphate:isopentenyl-diphosphate cistransferase (adding 9--11 isopentenyl units)

Reaction(IUBMB)

(2Z,6E)-farnesyl diphosphate + n isopentenyl diphosphate = n diphosphate + trans,polycis-polyprenyl diphosphate (n = 9--11) [RN:R09731]

Reaction(KEGG)

R09731

Substrate

(2Z,6E)-farnesyl diphosphate [CPD:C16826];
isopentenyl diphosphate [CPD:C00129]

Product

diphosphate [CPD:C00013];
trans,polycis-polyprenyl diphosphate [CPD:C19853]

Comment

Highest activity with (2Z,6E)-farnesyl diphosphate as allylic substrate. Broad product specificity with the major product being dodecaprenyl diphosphate. Synthesizes even C70 prenyl diphosphate as the maximum chain-length product [1].

History

EC 2.5.1.88 created 2010

Pathway

ec00900

Terpenoid backbone biosynthesis

ec01110

Biosynthesis of secondary metabolites

Orthology

K21273

trans,polycis-polyprenyl diphosphate synthase

Genes

SHAU:

K9S39_00850(uppS)

MLY:	CJ228_003870

PALU:

CJ193_000905

PHW:	G7075_08440

BLUT:

EW640_02245

BCAU:

I6G59_13875

AUS:	IPK37_16425

PAUS:

NCTC13651_01488(uppS)

PRV:	G7070_00365

BRT:	J4N02_06640

PSOI:

PCC79_06620

KFL:

Kfla_2449

KQI:	F1D05_32195

TFU:

Tfu_0853

THAO:

NI17_001400

TALX:

FOF52_00825

NDA:

Ndas_0730

NGV:	CDO52_20120

NEX:	NE857_10750

NEC:	KGD82_19315

NAKE:

KGD83_22070

NCG:	KGD84_23705

STRR:

EKD16_07660

SNAH:

OUQ99_23520

SAIU:

J4H86_07620

TCU:

Tcur_3231

ACTW:

F7P10_35510

AGRA:

AGRA3207_006527

AMAZ:

LUW76_40710

ACIR:

OG979_05575

SPIQ:

OHA34_34490

ACTQ:

OG417_18355

SRO:

Sros_2336

NOA:	BKM31_32885

NOW:	GBF35_11800

NCX:	Nocox_11025

NGN:	LCN96_12435

NFS:	OIE67_34555

TBI:

Tbis_1177

MHAI:

OHB01_22425

STP:	Strop_3446

SAQ:

Sare_3825

MAU:	Micau_4838

MIL:

ML5_3461

MICB:

MicB006_3858

MTUA:

CSH63_00310

MICH:

FJK98_25610

MTEM:

GCE86_18810

MCAB:

HXZ27_24530

MSAG:

GCM10017556_10970(uppS1)

VMA:	VAB18032_28301

MCRA:

ID554_22120

VER:	HUT12_29105

MENO:

Jiend_42340(uppS1)

MCHL:

PVK74_14445

MFEU:

H1D33_29935

MPRN:

Q3V37_13695

MHAW:

RMN56_18570

MCAY:

PVK37_30870

MICF:

QQG74_25120

ASE:

ACPL_1421

AMS:	AMIS_11890

ACTN:

L083_1597

ACTS:

ACWT_1300

AIH:	Aiant_56320(uppS1)

ACTR:

Asp14428_30000(uppS1)

ACTL:

L3i22_013320(uppS)

ASIC:

Q0Z83_075810

AOU:	ACTOB_001303

ACTE:

ACTI_32740(uppS_2)

AFS:

AFR_08000

PLK:	CIK06_21945

PLAB:

C6361_31565

PLAT:

C6W10_34995

PFLA:

Pflav_057510(uppS1)

PSUU:

Psuf_017140(uppS1)

ATL:	Athai_13260(uppS_2)

ASER:

Asera_60570(uppS1)

PRY:	Prubr_07990(uppS1)

CATI:

CS0771_00170(uppS1)

DVC:	Dvina_46555

DFU:	Dfulv_40965

DROS:

Drose_31170

DAUR:

Daura_44720

DMAT:

Dmats_40900

DACT:

KZZ52_52860

NHY:	JQS43_07375

CCAZ:

COUCH_31645

SNA:

Snas_2041

NAV:	JQS30_11505

GLY:	K3N28_04635

» show all

Reference

1 [PMID:19447338]

Authors

Ambo T, Noike M, Kurokawa H, Koyama T

Title

Cloning and functional analysis of cis-prenyltransferase from Thermobifida fusca.

Journal

J Biosci Bioeng 107:620-2 (2009)
DOI:10.1016/j.jbiosc.2009.02.006

Sequence

[tfu:Tfu_0853]

Other DBs

ExplorEnz - The Enzyme Database:

2.5.1.88

IUBMB Enzyme Nomenclature:

2.5.1.88

ExPASy - ENZYME nomenclature database:

2.5.1.88

BRENDA, the Enzyme Database:

2.5.1.88

LinkDB

REACTION: R09731

Entry

R09731                      Reaction

Name

(2Z,6E)-farnesyl-diphosphate:isopentenyl-diphosphate cistransferase (adding 9-11 isopentenyl units)

Definition

2-cis,6-trans-Farnesyl diphosphate + n Isopentenyl diphosphate <=> n Diphosphate + trans,polycis-Polyprenyl diphosphate

Equation

C16826 + n C00129 <=> n C00013 + C19853

Reaction class

RC00279

C00129_C19853

RC02839

C16826_C19853

Enzyme

2.5.1.88

Pathway

rn00900

Terpenoid backbone biosynthesis

rn01110

Biosynthesis of secondary metabolites

Brite

Enzymatic reactions [BR:br08201]
2. Transferase reactions
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.88
     R09731  2-cis,6-trans-Farnesyl diphosphate + n Isopentenyl diphosphate <=> n Diphosphate + trans,polycis-Polyprenyl diphosphate

Orthology

K21273

trans,polycis-polyprenyl diphosphate synthase [EC:2.5.1.88]

LinkDB

DBGET integrated database retrieval system