KEGG   ORTHOLOGY: K22323
Entry
K22323            Tight     KO                                     
Symbol
T3R
Name
3-hydroxy-1,2-didehydro-2,3-dihydrotabersonine reductase [EC:1.1.99.41]
Pathway
map00901  Indole alkaloid biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00965  Vinblastine biosynthesis, geissoschizine => vinblastine
Reaction
R11777  (3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine:acceptor oxidoreductase
R11802  (3R)-3-hydroxy-2,3-dihydrotabersonine:acceptor oxidoreductase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00901 Indole alkaloid biosynthesis
    K22323  T3R; 3-hydroxy-1,2-didehydro-2,3-dihydrotabersonine reductase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.99  With unknown physiological acceptors
    1.1.99.41  3-hydroxy-1,2-didehydro-2,3-dihydrotabersonine reductase
     K22323  T3R; 3-hydroxy-1,2-didehydro-2,3-dihydrotabersonine reductase
Genes
AG: AKM12281(T3R)
Reference
  Authors
Qu Y, Easson ML, Froese J, Simionescu R, Hudlicky T, De Luca V
  Title
Completion of the seven-step pathway from tabersonine to the anticancer drug precursor vindoline and its assembly in yeast.
  Journal
Proc Natl Acad Sci U S A 112:6224-9 (2015)
DOI:10.1073/pnas.1501821112
  Sequence
LinkDB

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