KEGG   Addendum: AKM12281
Entry
AKM12281          CDS       T10000                                 
Symbol
T3R
Name
(KEGG) 3-hydroxy-1,2-didehydro-2,3-dihydrotabersonine reductase (EC:1.1.99.41)
  KO
K22323  3-hydroxy-1,2-didehydro-2,3-dihydrotabersonine reductase [EC:1.1.99.41]
Taxonomy
TAX:4058
  Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Gentianales; Apocynaceae; Rauvolfioideae; Vinceae; Catharanthinae; Catharanthus
Organism
Catharanthus roseus
SSDB
Motif
Pfam: ADH_N ADH_zinc_N 2-Hacid_dh_C AlaDh_PNT_C ADH_zinc_N_2 F420_oxidored NAD_binding_7 ELFV_dehydrog GFO_IDH_MocA
Other DBs
NCBI-ProteinID: AKM12281
GB: KP122966
UniProt: A0A161CAI1
LinkDB
AA seq 352 aa
MAAKSVKALGLALKDSSGLFSPFNFSRRATGEHDVQLKVLYCGVCNFDNLMRRNKYGRTK
FPYVFGHEIVGVVTEVGSNVKKFKIGNKVGVSFIVDTCRECERCKIGQQIACKKAVSSDG
FFETPGYGGCSNIFVADENYVILWPENLPMDSGAPLLCIGITCYNPLRRFGLDKPGVRVG
IVGLGAVGHLAIKFAKAFGARVTLISSSPGKKDEAFQKFGVDSFLVSSNAEEMQAAAETL
DGILDTVPVVHPLEPLFALLKPLGKLIIIGEPHKPFEVSAMSLMEGGKIISASTGGSIKD
TQEIVDFAAEHNVVADVEVIPVDYVNTAMERLDKADVKYRFVIDIGNTFKSP
Reference
  Authors
Qu Y, Easson ML, Froese J, Simionescu R, Hudlicky T, De Luca V
  Title
Completion of the seven-step pathway from tabersonine to the anticancer drug precursor vindoline and its assembly in yeast.
  Journal
Proc Natl Acad Sci U S A 112:6224-9 (2015)
DOI:10.1073/pnas.1501821112

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