KEGG   ORTHOLOGY: K22879
Entry
K22879                      KO                                     
Symbol
hpyO
Name
FAD-dependent urate hydroxylase [EC:1.14.13.113]
Pathway
map00230  Purine metabolism
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
Module
M00546  Purine degradation, xanthine => urea
Reaction
R09514  urate,NADH:oxygen oxidoreductase (5-hydroxyisourate forming)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    K22879  hpyO; FAD-dependent urate hydroxylase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.113  FAD-dependent urate hydroxylase
     K22879  hpyO; FAD-dependent urate hydroxylase
Other DBs
COG: COG2072
GO: 0102099
Genes
CRE: CHLRE_06g288150v5
VCN: VOLCADRAFT_86764
CVR: CHLNCDRAFT_21314
KRD: A3780_00565
KOU: C0557_00815
SYM: K6K13_09440 K6K13_09480
PDZ: HHA33_18785
METY: MRY16398_37110
EBC: C2U52_26935
RIU: I2123_22295
GQU: AWC35_01895 AWC35_17225
RBAD: H2866_18690
RCB: O1V66_02490
NIG: C1N62_20010
PPUJ: E2566_14230
PPOO: LW347_13950
DDA: Dd703_1796
BGJ: AWC36_06155
BIZ: HC231_12765
EBI: EbC_37270
ERWI: GN242_17225
ERP: LJN55_18955
ERWE: GKQ23_04370
PVA: Pvag_pPag30384
PAGG: AL522_01665
PAO: Pat9b_3298
KLN: LH22_05875
PANT: PSNIH1_02755
PANS: FCN45_15900
PEY: EE896_21225
PDIS: D8B20_19870
PER: LAC65_13310
PJI: KTJ90_20135
PANO: OJ965_00910
PANE: P6287_16160
PAMT: IAI47_19885
PANZ: NR302_15895
PPHI: ACF2G4_19935
PSI: S70_02750
PSX: DR96_3720
PSTA: BGK56_06095
PTHA: OI982_20570
PRG: RB151_027490
PALA: CO695_11430
PHEI: NCTC12003_01494
PRQ: CYG50_02355
PRJ: NCTC6933_02417
PVC: G3341_07580
PMAG: JI723_07585
PHAG: PZ638_07795
PZJ: QS795_010985
PZN: ACE2AM_07585
PXH: ACE2AL_07975
XCC: XCC0279
XCB: XC_0289
XCA: xcc-b100_0304
XCP: XCR_4231
XCV: XCV0304
XAX: XACM_0281
XAC: XAC0296
XCI: XCAW_00696(trkA)
XCT: J151_00415
XCJ: J158_00412
XCU: J159_00412
XCN: J169_00411
XCW: J162_00411
XCR: J163_00411
XCM: J164_00411
XCF: J172_00406
XFU: XFF4834R_chr02700
XAO: XAC29_01520
XOO: XOO4365
XOR: XOC_4624
XGM: KFS84_15670
XVE: BJD12_14100
XPE: BJD13_15555
XHR: XJ27_17185
XGA: BI317_23270
XPH: XppCFBP6546_10400(hpyO)
XVA: C7V42_01335
XAN: AC801_01305
XAR: XB05_15280
XHY: FZ025_14310
XEU: XSP_000301(hpyO)
XHD: LMG31886_03210(hpyO)
XPR: MUG10_08830(hpyO)
XDY: NYR95_01685(hpyO)
XAS: HEP74_00985
XIN: Q7W82_18235
XAZ: XSP_000306(hpyO)
XTS: AB3X08_05370
XMD: AB3X07_05775
XBN: AB3X10_05465
PSD: DSC_09815
PWI: MWN52_08875
PST: PSPTO_2809
PSB: Psyr_2537
PSYR: N018_14590
PSP: PSPPH_2694
PAMG: BKM19_015710
PCI: PCH70_23550
PAVL: BKM03_15150
PVD: CFBP1590__2680
PCAB: JGS08_13485
PAST: N015_14235
PLIJ: KQP88_11310
PFUV: NLK61_27250
PPV: NJ69_04175
PSES: PSCI_0902
PPSY: AOC04_09605
PEZ: HWQ56_17430
PQI: KH389_17355
PCAS: LOY40_17790
PNB: NK667_12685
PPAO: K3169_12955
PSKU: KUIN1_25360
PSML: V6P94_14680
PSIV: LZ023_18125
HCS: FF32_01200
HHH: CLM76_11010
HASO: B2G49_02345
HAMS: NF683_01265
HAXH: J4377_13310
HALK: CUU95_10960
HVN: EI420_15180
ZPL: ZBT109_0699
HAA: A5892_03615
VMS: LVJ82_16680
AMAH: DLM_1384
MAER: DAI18_05545
RSO: RSc1881
RSE: F504_1880
RPU: CDC45_09685
RNC: GO999_07185
RSC: RCFBP_11451
RSL: RPSI07_1512
RSN: RSPO_c01509
RSM: CMR15_11443
RSY: RSUY_22400
RSG: JK151_20890
RPI: Rpic_2082
RPF: Rpic12D_1759
RPJ: N234_07905
RMN: TK49_13335
RIN: ACS15_1247
RWE: KOL96_16690
REH: H16_A1586(trkA1)
CNC: CNE_1c16120(trkA1)
CUH: BJN34_08065
REU: Reut_A1449
CTI: RALTA_A1513
CBW: RR42_m2178 RR42_m2450
CGD: CR3_1449(trkA)
CCUP: BKK81_10870 BKK81_11110
CUP: BKK80_11125 BKK80_11365
CUU: BKK79_01470 BKK79_01710
COX: E0W60_17670
CCAX: KZ686_11100
CUK: KB879_08145
CNAN: A2G96_11010
CUPR: IC580_07605
CUPP: CTP10_R13810 CTP10_R53050
BTD: BTI_3700
BHG: I6G56_21985
BUD: AQ610_24715
BVI: Bcep1808_4049
BVE: AK36_4649
BUR: Bcep18194_B2537
BCM: Bcenmc03_3939
BCH: Bcen2424_3581
BCJ: BCAM0608
BCEN: DM39_4539
BCEO: I35_4504
BAM: Bamb_5315
BMJ: BMULJ_03413
BMU: Bmul_5104
BMK: DM80_4281
BMUL: NP80_3619
BCED: DM42_4482
BCEP: APZ15_21410
BSEM: WJ12_23030
BPSL: WS57_10830
BMEC: WJ16_22065
BSTL: BBJ41_30665
BANN: JFN94_20595
BARI: NLX30_19735
BAEN: L3V59_32725
BSER: R0290_22710
BUK: MYA_3736
BUL: BW21_5699
BGP: BGL_2c15640
BPLA: bpln_2g16340
BUM: AXG89_36750
BUI: AX768_15775
BURK: DM992_28625
BURT: BTHE68_58590
BURM: GJG85_27245
BXE: Bxe_A2162 Bxe_C0093 Bxe_C0114
BXB: DR64_4316 DR64_8313 DR64_8334
BGE: BC1002_5874
BFN: OI25_4224 OI25_56
BCAI: K788_0001411 K788_0001442
PARB: CJU94_14785 CJU94_21780
PHS: C2L64_29465
PTER: C2L65_18910
PCAF: DSC91_001711
PMEG: FNZ07_12290
PGIS: I6I06_26510
PACP: FAZ97_19390
PDIO: PDMSB3_2169
PKF: RW095_09060
PPAI: E1956_36735
PHUN: U0042_25125
PLAD: PPGU16_40800
PAZZ: PBP221_49510
PPK: U875_05700
PPNO: DA70_22775
PPNM: LV28_07945
PRB: X636_03890
PPUL: RO07_02085
PSPU: NA29_09505
PAPI: SG18_02365
PVE: UC34_18295
POX: MB84_23090 MB84_29035
PFG: AB870_05305
PNR: AT302_13500
PFIB: PI93_009760
PCOM: NTU39_20115
PLG: NCTC10937_02948
CABA: SBC2_37640(hpyO)
CABK: NK8_56050
BAV: BAV1564
BHO: D560_3852
BHM: D558_3825
BHZ: ACR54_01991
BPDZ: BBN53_12175
BOJ: CBF45_08035
AXY: AXYL_03753
AXO: NH44784_053021
AXN: AX27061_3537
AXX: ERS451415_03541
ADT: APT56_16820
AIS: BUW96_08490
ASW: CVS48_21010
ACHR: C2U31_22855
ACHB: DVB37_11275
ADY: HLG70_04505
ACHO: H4P35_14990
AMUI: PE062_11715
APES: FOC84_26700
AAEG: RA224_14180
ASEL: RAS12_04120
ACHM: V6V88_15485
ACHA: KYT87_12075
AVH: WHX56_22200
ACHH: ABFG95_02150
POLL: OEG81_16810
AKA: TKWG_01985
AMIM: MIM_c03090
PHN: PAEH1_05725
ODI: ODI_R2747
PACR: FXN63_03425 FXN63_12400 FXN63_12795
KGY: EHF36_08190
PARK: LSG25_12890
AJS: Ajs_3884
ACID: CBP33_16565
ACIP: CBP36_16990
ACIN: CBP34_17345
ACIS: CBP35_01930
ACIO: EAG14_10870
ARAD: KI609_00240
ACIQ: ACDW_35690
ASAH: AVXHC19_45780
AAV: Aave_4505
AAA: Acav_4408
AMON: H9L24_12240
VEI: Veis_0812
DAC: Daci_0532
DEL: DelCs14_0476
DTS: BI380_24310
DHK: BO996_00600
DLA: I6G47_24685
VAP: Vapar_0417
VPE: Varpa_0445
VPD: VAPA_1c04970
VAA: AX767_01600
VBO: CKY39_02405
VAM: C4F17_31880
VAZ: H7F35_14685
VAV: IG196_01135
VAE: RZE79_02320
CTT: CtCNB1_0374
CTES: O987_01935
CKE: B5M06_10060
CAQT: KAQ61_17980
CODO: LAD35_01315
CTEZ: CT3_35670
AANT: HUK68_09455 HUK68_22025
CRJ: QMY55_01805
CENP: M9799_16480
COMB: MJ205_20765
CSQU: N4T19_15640
ADN: Alide_3951
ADK: Alide2_4296
DPY: BA022_16585
DIH: G7047_24655
DAER: H9K75_12355
DRG: H9K76_00150
DLS: P4826_15045
DIJ: HND92_17535
DIM: K2L43_17120
DIS: I3K84_14775
DIA: Dtpsy_3157
MELA: C6568_10750
HSE: Hsero_1563
HSZ: ACP92_07855
HHT: F506_13455
HRB: Hrubri_1468
HEE: hmeg3_11080
HHF: E2K99_07935
HFR: G5S34_08810
HEW: HBDW_14620
GLC: JQN73_18055
XYK: GT347_19860 GT347_26495
XYG: R9X41_20765
MLN: A9174_34040
NKI: KW403_18930
NRH: T8J41_22050
NTU: NTH_02833(hpyO)
CHEA: PVE73_18215
AAK: AA2016_2189
AMIH: CO731_00347 CO731_05352
AMIS: Amn_41430
ANJ: AMD1_PA0049
PHT: BLM14_16140
SME: SM_b20280
SMK: Sinme_3892
SMQ: SinmeB_4389
SMX: SM11_pD1330
SMI: BN406_06385
SMEG: C770_GR4pD1316
SMEL: SM2011_b20280
SMER: DU99_31965
SMD: Smed_3851
EMX: FKV68_24825
SKM: PZL22_001050
EAH: FA04_25650
ECAA: J3R84_33475
ENP: JVX98_06660
ATU: Atu5424 Atu6077
ATA: AWN88_07325
AGT: EYD00_17850
ALF: CFBP5473_15145 CFBP5473_17280
ARUI: G6M88_15575
AVV: RvVAT039_36790(hpyO)
AVF: RvVAR031_39870(hpyO)
ASAL: CFBP5507_26540
RIR: BN877_II0844
RPUS: CFBP5875_18020
ALEG: CFBP4996_14720
AGRC: GSF67_26515
AVI: Avi_5281
RET: RHE_PE00226
REC: RHECIAT_CH0003402
REL: REMIM1_PD00236
RLE: RL1041
RLG: Rleg_0669
RLU: RLEG12_25940
RTR: RTCIAT899_PC07985
RHL: LPU83_pLPU83d0404
RHN: AMJ98_PD00229
RHX: AMK02_PE00229
RHV: BA939_22620
REZ: AMJ99_PC00230
RHR: CKA34_31150 CKA34_32630
RHID: FFM81_005185
RRG: J3P73_05880 J3P73_29460 J3P73_32220
RLS: HB780_11965
RSUL: N2599_05750 N2599_32455
RLW: RlegWSM1455_33390
RRHO: PR018_18020
RTU: PR017_24280 PR017_27840
ARA: Arad_14232 Arad_7954 Arad_9888
ARO: B0909_18220
RBW: RLCC275e_03240 RLCC275e_28970
RIF: U5G49_000655 U5G49_006605
RHIB: I8E17_26215 I8E17_29060
RHIA: ACO34A_25375 ACO34A_25475
RHIY: BLX90_17355
RHIW: KQ933_22695 KQ933_30625 KQ933_30675
NGL: RG1141_PA06260 RG1141_PA06550
NGG: RG540_PA06090 RG540_PA06390
NEN: NCHU2750_46400 NCHU2750_56150
NPM: QEO92_06980 QEO92_07030
ABAW: D5400_06830
KAI: K32_47000
PSCQ: KHQ08_03980
PSXF: LDL70_01995
BJA: blr0238(blr0238) blr3336(blr3336)
BJU: BJ6T_64560
BJP: RN69_31290
BRA: BRADO1796
BBT: BBta_2112 BBta_4836
BRS: S23_46980
AOL: S58_57470
BRAD: BF49_1409
BRO: BRAD285_5495
BOT: CIT37_37100
BRQ: CIT40_10920
BSYM: CIT39_09930
BARH: WN72_14485 WN72_19685 WN72_35980
BVZ: BRAD3257_5405
BEL: BE61_27900
BDG: LPJ38_19705
BSEP: HAP48_0008120
BBAN: J4G43_019000 J4G43_020265 J4G43_027210
BCAN: BcanWSM471_15670
BBRA: QA636_08530
BGK: IC762_02220
BCOU: IC761_22925
BPAH: QA639_10215
BXN: I3J27_12945
BROS: QUH67_13390 QUH67_29035
BRAZ: LRP30_15470
BOY: LQG66_04470 LQG66_15085
BRAI: FJV43_30085
BLUP: AB3L03_05350
RBK: E0H22_22790
RHOR: ONR75_25580
VGO: GJW-30_1_04007
TRB: HB776_00850
TARD: RSO67_25290
TARV: FIU28_01080
BVV: BHK69_00155 BHK69_03000
BOP: AXW83_05385 AXW83_17940
BOS: BSY19_4208
BOI: BLM15_25295
BOF: FQV39_01835 FQV39_23425
BOW: NWE53_07135
BOSE: RMR04_01420 RMR04_04125
BAPI: BBC0122_017130
BAPA: BBC0178_017130
XAU: Xaut_2767
XDI: EZH22_01645
AZC: AZC_1960 AZC_3772
AQI: J5J86_10785
PTAW: DW352_01945
MAQU: Maq22A_1p31745(trkA) Maq22A_c06055(trkA)
MEE: DA075_00240 DA075_21885
MTEA: DK419_05885 DK419_15075
MIND: mvi_08060 mvi_46960
MOG: MMB17_22765
MOC: BB934_43670
MLD: U0023_31840
BID: Bind_1848
RHZ: RHPLAN_06660
PHL: KKY_840 KKY_861
DNP: N8A98_16420 N8A98_18170
DEVD: GHV40_11655
PLEO: OHA_1_00486 OHA_1_01086 OHA_1_01485
HDI: HDIA_0374
MEY: TM49_08025
MAAD: AZF01_00420 AZF01_04370
MMED: Mame_00036(iucD) Mame_00571 Mame_02840 Mame_04367 Mame_04371
MLUT: JET14_01625 JET14_05400
AALA: IGS74_04135
AALM: LUX29_04740
JIE: OH818_25160
JAV: OXU80_03705
NOH: G5V57_23475
RPOP: K1718_07860
PHR: C6569_09820
PSTG: E8M01_17965 E8M01_20595
PAQT: E8L99_10475 E8L99_21530
ACUT: MRB58_20815
MFLG: ABS361_15810
AEX: Astex_2529
ASTD: ATDW_24910
RDE: RD1_0284
RLI: RLO149_c043010
KVL: KVU_2406 KVU_PB0179
KVU: EIO_0058 EIO_3146
KRO: BVG79_00076 BVG79_01387 BVG79_01910
OAT: OAN307_c17980
CID: P73_3149
YPAC: CEW88_03975
YAN: AYJ57_24240
PABY: Ga0080574_TMP2577 Ga0080574_TMP4529
MALU: KU6B_15890
PLCG: RVY76_17620
PSTL: JHW45_15990
DAA: AKL17_0101
BOO: E2K80_04395
PPRU: FDP22_09865
THAS: C6Y53_18000
CMAG: CBW24_03420
MANH: LA6_003069
NPP: PP1Y_Mpl6510
NPN: JI59_06010 JI59_13860
NRE: BES08_00655
NOV: TQ38_012760
NDR: HT578_09770
NCP: U0041_11850
SMAZ: LH19_05595
SPHI: TS85_03625
SSAN: NX02_01460
SPAN: AWL63_07780
SARI: H5J25_11865
SNAP: PQ455_00380
SHYD: CJD35_17420
SPAG: sphantq_04369(hpyO)
SPCA: GL174_09555
GOX: GOX0905
GOH: B932_1263 B932_3115 B932_3802
GOY: GLS_c09860
GAL: A0U94_11990
GTI: FXF46_04925
GSP: IGS75_02920 IGS75_03255 IGS75_04870
GFA: MKW11_04890
GDI: GDI1999
GDJ: Gdia_0222
GXY: GLX_26930
GXL: H845_636
KNA: B0W47_13570 B0W47_14135 B0W47_16505
KEU: S101446_03026
KSC: CD178_00379
KRE: GWK63_04115
KOI: LV478_09125
APT: APA01_12950
APW: APA42C_12950
APF: APA03_12950
APU: APA07_12950
APG: APA12_12950
APQ: APA22_12950
APX: APA26_12950
APZ: APA32_12950
APK: APA386B_130
ASZ: ASN_2430 ASN_3554
ASV: WG31_06990
AACE: A0U92_10785
APER: A0U91_00670 A0U91_07260
APOM: CPF11_00960
ATO: CIW82_13750
AASC: A4S02_04485
ACET: DS739_06710
AOY: EOV40_006020
ABG: Asbog_01727
KBA: A0U89_04065 A0U89_13835
NCH: A0U93_02325
NTN: D5366_09745
EBLA: JGUZn3_21310(hpyO)
LCK: HN018_01180 HN018_03430 HN018_19065 HN018_22880
KHA: IFJ82_12005
RAP: RHOA_3321
NGU: QN315_01140 QN315_08090
RGI: RGI145_00730 RGI145_12990 RGI145_16835
ROS: CTJ15_15935 CTJ15_19325 CTJ15_23385
RMUC: FOB66_14640 FOB66_19190 FOB66_22505
RMT: IAI58_06535 IAI58_13240
RFL: Rmf_17410 Rmf_27420
RCV: PFY06_07100 PFY06_19930
SRF: LHU95_00355 LHU95_00970
ELIO: KO353_02260 KO353_06700
AZL: AZL_a01360
ABS: AZOBR_p270296
ABQ: ABAZ39_29505
AHU: A6A40_18795
AZT: TSH58p_30485
AZZ: DEW08_24245
AARE: D3093_30535
ADJ: ACIU1J_21580
NCB: C0V82_21270
NACI: NUH88_21955
THAR: T8K17_08420
PBR: PB2503_11534
SNEA: NBZ79_14290
MFB: MFUL124B02_34240
MYM: A176_001008
CCX: COCOR_04639
MFU: LILAB_16815
MMAS: MYMAC_005674
PPAK: JY651_01305
SUR: STAUR_1039
AVM: JQX13_20675
MBD: MEBOL_002474
CFUS: CYFUS_009293
CCRO: CMC5_071180
SAMY: DB32_006566
PUV: PUV_03850 PUV_18920
VEG: SAMN05444156_0035
BTHT: H175_328p258
BTHY: AQ980_30405
BACQ: DOE78_15650
BCIR: C2I06_17680
NTX: NQZ71_02740
NIL: L8T27_018965
NTGC: AB3U99_23450
BMQ: BMQ_1875
BMD: BMD_1868
BMH: BMWSH_3382
BMEG: BG04_4208
BKW: BkAM31D_24995
BKO: CKF48_06255
LYG: C1N55_01845
LYP: MTP04_03650(hpyO)
APAK: AP3564_04520
ACOP: RI196_18195
PASA: BAOM_5064
GCS: MUN88_07550
GSM: MUN87_11350
MSEM: GMB29_09145
DOM: RRU94_08710
STEA: C0679_04185
PUK: PU629_03690
PSAB: PSAB_09145
PDU: PDUR_10360
PBD: PBOR_12185
PGM: PGRAT_11215
PAEN: P40081_11915
PAEQ: R50912_11500
PSTE: PSTEL_10375
PAEA: R70723_10940
PAEE: R70331_10705
PAEH: H70357_12200
PBJ: VN24_03900
PRI: PRIO_2419
PSON: JI735_20920
PBV: AR543_10075
PXL: BS614_13745
PDH: B9T62_06290
PPRT: ET464_06450
PBAC: HUB98_26795
PSOP: KP014_12880
PTRI: KDC22_10365
PTJ: JRJ22_09220
PALR: HGI30_09220
PKA: PQ456_07460
PMAH: PTQ21_15075
PAMY: P9222_27735
PDY: QJQ58_07240
PHK: SK066_15935
PNK: AASFL403_11435
PPAB: KET34_11150
PHEX: L0M14_24330
PEZZ: HW560_28410
PAUB: PUR_20270(hpyO)
COH: EAV92_14900
UTH: DKZ56_09440
MVA: Mvan_3152
MAUS: JN090_15045
CVA: CVAR_2631
CTER: A606_11085
CFN: CFAL_00600
CGY: CGLY_01820
CPRE: Csp1_03170(hpyO)
CANS: GP473_08385
CHEI: CHEID_09535
NNO: NONO_c30360
RSF: OED52_17110
GRU: GCWB2_04395
GAM: GII34_04955
GPD: GII33_04415
DIT: C3V38_02960
DIZ: CT688_12825
DPC: A6048_13560
DKN: NHB83_13660
DCD: VYL96_13160
AREV: RVR_9762
MTS: MTES_1232
MIH: BJP65_07605
MICM: CHE218_18370(hpyO)
AGX: AGREI_3016
DCP: RN607_05750
MHAI: OHB01_18810
AIH: Aiant_83310
NON: NOS3756_46980
NFL: COO91_07974
NSH: GXM_07437
NED: HUN01_01880 HUN01_02840
NCW: NIES2107_63660
NOSU: JYQ62_28545
NOSQ: PQG02_27965
AVA: Ava_0103
ANN: EH233_20845
CALO: Cal7507_5861
CALN: NIES2098_21230
MDP: NIES3275_19750
TOQ: HCG51_03910
TTQ: NIES37_65340
ALAX: NIES50_21230
SCYT: SAMD_77520 SAMD_81260
SCYS: NIES4073_41730
 » show all
Reference
PMID:23760935
  Authors
Michiel M, Perchat N, Perret A, Tricot S, Papeil A, Besnard M, de Berardinis V, Salanoubat M, Fischer C
  Title
Microbial urate catabolism: characterization of HpyO, a non-homologous isofunctional isoform of the flavoprotein urate hydroxylase HpxO.
  Journal
Environ Microbiol Rep 4:642-7 (2012)
DOI:10.1111/j.1758-2229.2012.00390.x
  Sequence
[xcc:XCC0279]
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