ORTHOLOGY: K23741 Help
Entry
Symbol
MAN1B, MNS3
Name
endoplasmic reticulum Man9GlcNAc2 1,2-alpha-mannosidase [EC:
3.2.1.209 ]
Pathway
map00513 Various types of N-glycan biosynthesis
map04141 Protein processing in endoplasmic reticulum
Module
M00073 N-glycan precursor trimming
M00074 N-glycan biosynthesis, high-mannose type
Reaction
R06722 alpha 1,2-mannosyloligosaccharide alpha-D-mannohydrolase
Disease
H00768 Autosomal recessive intellectual developmental disorder
Brite
KEGG Orthology (KO) [BR:ko00001 ]
09100 Metabolism
09107 Glycan biosynthesis and metabolism
00510 N-Glycan biosynthesis
K23741 MAN1B, MNS3; endoplasmic reticulum Man9GlcNAc2 1,2-alpha-mannosidase
00513 Various types of N-glycan biosynthesis
K23741 MAN1B, MNS3; endoplasmic reticulum Man9GlcNAc2 1,2-alpha-mannosidase
09120 Genetic Information Processing
09123 Folding, sorting and degradation
04141 Protein processing in endoplasmic reticulum
K23741 MAN1B, MNS3; endoplasmic reticulum Man9GlcNAc2 1,2-alpha-mannosidase
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking
K23741 MAN1B, MNS3; endoplasmic reticulum Man9GlcNAc2 1,2-alpha-mannosidase
Enzymes [BR:ko01000 ]
3. Hydrolases
3.2 Glycosylases
3.2.1 Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
3.2.1.209 endoplasmic reticulum Man9GlcNAc2 1,2-alpha-mannosidase
K23741 MAN1B, MNS3; endoplasmic reticulum Man9GlcNAc2 1,2-alpha-mannosidase
Membrane trafficking [BR:ko04131 ]
Endoplasmic reticulum (ER) - Golgi transport
Forward pathways
ER-Golgi intermediate compartment (ERGIC) proteins
K23741 MAN1B, MNS3; endoplasmic reticulum Man9GlcNAc2 1,2-alpha-mannosidase
BRITE hierarchy
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Genes
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Taxonomy UniProt
Reference
Authors
Gonzalez DS, Karaveg K, Vandersall-Nairn AS, Lal A, Moremen KW
Title
Identification, expression, and characterization of a cDNA encoding human endoplasmic reticulum mannosidase I, the enzyme that catalyzes the first mannose trimming step in mammalian Asn-linked oligosaccharide biosynthesis.
Journal
Sequence
Reference
Authors
Liebminger E, Huttner S, Vavra U, Fischl R, Schoberer J, Grass J, Blaukopf C, Seifert GJ, Altmann F, Mach L, Strasser R
Title
Class I alpha-mannosidases are required for N-glycan processing and root development in Arabidopsis thaliana.
Journal
Sequence
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