KEGG ORTHOLOGY: K25483

ORTHOLOGY: K25483

Entry

K25483                      KO

Symbol

GPHA2

Name

glycoprotein hormone alpha-2

Pathway

map04024

cAMP signaling pathway

map04080

Neuroactive ligand-receptor interaction

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04024 cAMP signaling pathway
    K25483  GPHA2; glycoprotein hormone alpha-2
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    K25483  GPHA2; glycoprotein hormone alpha-2
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides
    K25483  GPHA2; glycoprotein hormone alpha-2
Cytokines and neuropeptides [BR:ko04052]
Neuropeptides
  GPCR binding
   K25483  GPHA2; glycoprotein hormone alpha-2

Other DBs

GO:

0031531

Genes

HSA:	170589(GPHA2)

PTR:	744235(GPHA2)

PPS:	100969482(GPHA2)

GGO:	101130927(GPHA2)

PON:	100440364(GPHA2)

PPYG:

129007143(GPHA2)

NLE:	100606253(GPHA2)

HMH:	116468975(GPHA2)

SSYN:

129466375(GPHA2)

MCC:	717261(GPHA2)

MCF:	102129982(GPHA2)

MTHB:

126935626

MNI:	105469540(GPHA2)

CSAB:

103232568(GPHA2)

CATY:

105577468(GPHA2)

PANU:

100137476(GPHA2)

TGE:	112606925(GPHA2)

MLEU:

105549119(GPHA2)

RRO:	104662841(GPHA2)

RBB:	108543039(GPHA2)

TFN:	117079878(GPHA2)

PTEH:

111522312(GPHA2)

CANG:

105512192(GPHA2)

CJC:	100407720(GPHA2)

SBQ:	101028874(GPHA2)

CIMI:

108310269(GPHA2)

ANAN:

110566989(GPHA2)

CSYR:

103275603(GPHA2)

MMUR:

105878496(GPHA2)

PCOQ:

105827461(GPHA2)

OGA:	100946127(GPHA2)

MMU:	170458(Gpha2)

MCAL:

110285302(Gpha2)

MPAH:

110322093(Gpha2)

RNO:	171158(Gpha2)

MCOC:

116103442(Gpha2)

ANU:	117711077(Gpha2)

ASYL:

127691729(Gpha2)

MUN:	110549338(Gpha2)

CGE:	100759178(Gpha2)

MAUA:

101844503(Gpha2)

PROB:

127228763(Gpha2)

PLEU:

114682089(Gpha2)

MORG:

121454178(Gpha2)

MFOT:

126498242

AAMP:

119806588(Gpha2)

NGI:	103738771(Gpha2)

HGL:	101706500(Gpha2)

CPOC:

100721321(Gpha2)

CCAN:

109687167(Gpha2)

DORD:

105989179(Gpha2)

DSP:	122105373(Gpha2)

PLOP:

125361733(Gpha2)

NCAR:

124958312

MMMA:

107135992(Gpha2)

ITI:	101957933(Gpha2)

OCU:

127487006

TUP:	102472683(GPHA2)

GVR:	103584017 103596359(GPHA2)

VVP:	112924035(GPHA2)

VLG:	121471448(GPHA2)

NPO:	129500392(GPHA2)

AML:	109488337(GPHA2)

ELK:

111149987

LLV:

125078769

MPUF:

101681684(GPHA2)

MNP:	132008428(GPHA2)

MLK:	131815062(GPHA2)

ORO:	101368390(GPHA2)

EJU:	114220259(GPHA2)

ZCA:	113914447(GPHA2)

MLX:	118016019(GPHA2)

NSU:	110576188(GPHA2)

LWW:	102728060(GPHA2)

FCA:	101081412(GPHA2)

PYU:	121023818(GPHA2)

PCOO:

112851922(GPHA2)

PBG:	122483985(GPHA2)

PVIV:

125146602(GPHA2)

LRUF:

124506109

LGF:	123601920(GPHA2)

AJU:

106971155

PTG:	102953049(GPHA2)

PPAD:

109246692(GPHA2)

PUC:

125931273

PLEZ:

122200327(GPHA2)

HHV:	120240156(GPHA2)

BTA:	617578(GPHA2)

BOM:	102287521(GPHA2)

BIU:	109554578(GPHA2)

BBUB:

102413991(GPHA2)

BBIS:

104987204(GPHA2)

CHX:	102185538(GPHA2)

OAS:	101119430(GPHA2)

BTAX:

128069261(GPHA2)

CSUM:

138082649(GPHA2)

ODA:	120874711(GPHA2)

CCAD:

122431124(GPHA2)

MREE:

136169707(GPHA2)

OVR:	110136235(GPHA2)

MBEZ:

129548336(GPHA2)

SSC:	100516058(GPHA2)

CFR:	102521063(GPHA2)

CBAI:

105070657(GPHA2)

CDK:	105102627(GPHA2)

VPC:	102544466(GPHA2)

BACU:

102997956(GPHA2)

BMUS:

118900218(GPHA2)

LVE:	103074348(GPHA2)

OOR:	101282122(GPHA2)

LALB:

132525665(GPHA2)

DLE:	111183788(GPHA2)

PCAD:

102995109(GPHA2)

PSIU:

116758684(GPHA2)

NASI:

112402520(GPHA2)

ECB:	111775964(GPHA2)

EPZ:	103559134(GPHA2)

MYB:	102244708(GPHA2)

MYD:	102767616(GPHA2)

MMYO:

118665342(GPHA2)

MLF:	102416931(GPHA2)

MDT:	132241450(GPHA2)

MYUM:

139017672(GPHA2)

PKL:	118714954(GPHA2)

EFUS:

103302064(GPHA2)

MNA:	107533584(GPHA2)

DRO:	112317078(GPHA2)

SHON:

118991741(GPHA2)

AJM:	119050248(GPHA2)

PDIC:

114499153(GPHA2)

PHAS:

123829223(GPHA2)

MMF:	118628353(GPHA2)

PPAM:

129068592(GPHA2)

HAI:	109384308(GPHA2)

RFQ:	117031018(GPHA2)

PALE:

102895144(GPHA2)

PGIG:

120600688(GPHA2)

PVP:	105297867(GPHA2)

RAY:	107517088(GPHA2)

MJV:	108396379(GPHA2)

TOD:	119250530(GPHA2)

SARA:

105943341(GPHA2)

SFUM:

130039737(GPHA2)

SETR:

126018882(GPHA2)

LAV:	100665731(GPHA2)

TMU:

101345735

ETF:	101656013(GPHA2)

DNM:	101431824(GPHA2)

MDO:	100017757(GPHA2)

GAS:	123256103(GPHA2)

SHR:	116419976(GPHA2)

AFZ:

127540104

PCW:	110195335(GPHA2)

TVP:	118853536(GPHA2)

OAA:	114810014(GPHA2)

TACU:

119943784(GPHA2)

CJO:	116652731(GPHA2)

ZLE:	135460317(GPHA2)

HRT:	120747795(GPHA2)

SHAB:

115603522(GPHA2)

AGEN:

126034696

PSS:	102453046(GPHA2)

CMY:	102943742(GPHA2)

CCAY:

125639735(GPHA2)

DCC:	119859116(GPHA2)

CPIC:

101938072(GPHA2)

TST:	117880016(GPHA2)

CABI:

116836188(GPHA2)

MRV:	120409083(GPHA2)

ACS:	100555894(gpha2)

ASAO:

132764452(GPHA2)

PVT:	110090512(GPHA2)

SUND:

121916138(GPHA2)

PBI:	103059475(GPHA2)

CTIG:

120314920(GPHA2)

PGUT:

117657692(GPHA2)

APRI:

131186462(GPHA2)

PTEX:

113447445(GPHA2)

NSS:	113424180(GPHA2)

VKO:	123021799(GPHA2)

PMUA:

114586380(GPHA2)

PRAF:

128404116(GPHA2)

HCG:	128337372(GPHA2)

GJA:	107110073(GPHA2)

STOW:

125442658(GPHA2)

EMC:	129324447(GPHA2)

XLA:	108713884(gpha2.L)

XTR:	100490777(gpha2)

NPR:	108794285(GPHA2)

RTEM:

120916950(GPHA2)

BBUF:

120980894(GPHA2)

BGAR:

122920172(GPHA2)

PWL:	138258631(GPHA2)

MUO:	115481055(GPHA2)

GSH:	117364511(GPHA2)

DRE:	100310882(gpha2)

SRX:	107749831 107750665(gpha2)

SANH:

107668374 107691990(gpha2)

SGH:	107563350(gpha2) 107588222

CCAR:

109093069(gpha2)

CAUA:

113052538 113105841(gpha2)

CGIB:

127961160 128017101

PTET:

122348172(gpha2)

LROH:

127168604(gpha2)

OMC:	131544515(gpha2)

PPRM:

120470684(gpha2)

RKG:	130102722(gpha2)

MAMB:

125264110(gpha2)

CIDE:

127516112

CERY:

137031057(gpha2)

MASI:

127414948 127445434

TROS:

130556344(gpha2)

TDW:	130428906(gpha2)

PDAB:

135730668(gpha2)

IPU:

108267541

IFU:	128610774(gpha2)

PHYP:

113539960(gpha2)

TFD:	113635199(gpha2)

TVC:	132847959(gpha2)

CGAR:

128519892(gpha2)

NGRA:

132888188(gpha2)

AMEX:

103031294(gpha2)

CMAO:

118826643(gpha2)

EEE:	113579811(gpha2)

CHAR:

105895471(gpha2)

TRU:	101072430 115246478

TFS:	130522258(gpha2)

TNG:	GSTEN00025869G001

LCO:	104918727(gpha2)

NCC:	104948197(gpha2)

TBEN:

117487825(gpha2)

CGOB:

115023956(gpha2)

PGEO:

117463524(gpha2)

GACU:

117562909(gpha2)

EMAC:

134876239(gpha2)

ELY:	117246431(gpha2)

EFO:	125883831(gpha2)

PLEP:

121961888(gpha2)

SLUC:

116042245(gpha2)

ECRA:

117935246(gpha2)

ESP:	116669441(gpha2)

PFLV:

114545419(gpha2)

GAT:	120822634(gpha2)

PPUG:

119222183(gpha2)

AFB:	129093168(gpha2)

CLUM:

117748156(gpha2)

PSWI:

130212140(gpha2)

CANA:

137792113(gpha2)

CVE:	137874835(gpha2)

MSAM:

119911740(gpha2)

SCHU:

122869669(gpha2)

CUD:	121504151(gpha2)

SPUL:

138601263(gpha2)

LMIX:

132958990(gpha2)

ALAT:

119027096(gpha2)

ASTR:

137590990(gpha2)

MZE:	101473834(gpha2)

ONL:	100707035(gpha2)

OAU:	116317886(gpha2)

OLA:	101171530(gpha2)

OML:	112155975(gpha2)

CSAI:

133420683(gpha2)

XMA:	102220251(gpha2)

XCO:	114157979(gpha2)

XHE:	116732174(gpha2)

PRET:

103480750(gpha2)

PFOR:

103153620(gpha2)

PLAI:

106948304(gpha2)

PMEI:

106916900(gpha2)

GAF:	122820312(gpha2)

PPRL:

129373320(gpha2)

CVG:	107084141(gpha2)

CTUL:

119776379(gpha2)

GMU:	124880137(gpha2)

NFU:	107377129(gpha2)

KMR:	108242885(gpha2)

ALIM:

106524980(gpha2)

NWH:	119409489(gpha2)

AOCE:

111588387(gpha2)

EJA:	138204195(gpha2)

BFRE:

138631821(gpha2)

MCEP:

125009176(gpha2)

CSEM:

103384252(gpha2)

POV:	109634776(gpha2)

SSEN:

122765884(gpha2)

SSOE:

131457123(gpha2)

HSP:	118102793(gpha2)

PPLT:

128430427(gpha2)

SMAU:

118300171(gpha2)

LCF:

108888777

SDU:	111231355(gpha2)

SLAL:

111666421(gpha2)

XGL:	120797652(gpha2)

HCQ:	109506962(gpha2)

SSCV:

125990488(gpha2)

SBIA:

133494818(gpha2)

PTAO:

133472751(gpha2)

ENY:	140368345(gpha2)

MALB:

109965826(gpha2)

BSPL:

114865702(gpha2)

SJO:	128384041(gpha2)

SSCO:

134006071(gpha2)

GMH:	115529516(gpha2)

SASA:

106609030

STRU:

115185001 115198620

OTW:	112215067 121847599(gpha2)

OMY:	118965980(gpha2)

OGO:	124014590 124017501

ONE:	115133748(gpha2)

OKI:	109896338 116353938(gpha2)

OKE:	118392764 127916239(gpha2)

OMM:	135509902(gpha2) 135515452

OCLA:

139379539 139415855

SALP:

111956232(gpha2)

SNH:	120043314(gpha2) 120049304

CCLU:

121554366(gpha2) 121572727

SFM:	108925218(gpha2)

PKI:	111834787(gpha2)

AANG:

118223208(gpha2)

AROT:

135251563(gpha2)

CCOG:

133123144(gpha2)

LOC:	102692115(gpha2)

PSPA:

121306299(gpha2)

ARUT:

117398567 117967846

PSEX:

120533586(gpha2)

LCM:	102363690(GPHA2)

RTP:	125487669(gpha2)

HOC:	132836197(gpha2)

PMRN:

103091845 116953955

LRJ:	133342188 133356360 133356361

BFO:

BBEL:

CIN:

SCLV:

SPU:	100889017(gpa2) 100889174(gpa2)

LPIC:

129265478 129265984

AJJ:	139971542 139971544

APLC:

110977635 110977672

ARUN:

117291905 117291914

AAMU:

139947498 139947538

AFIL:

140157305 140157386 140158942 140159026

PFLL:

139149710

DME:	Dmel_CG17878(Gpa2)

DER:

26526449

DSE:	116803612 116803617 116803619

DSI:	Dsimw501_GD27627(Dsim_GD27627)

DYA:	Dyak_GE29190

DAN:

26514552

DSR:	110184512 110184514

DPO:

DPE:

DMN:

DWI:

DMO:	Dmoj_GI11802

DAZ:

108610349

DNV:

115562866

DHE:

111593145

DVI:	6629005(Gpa2)

CCAT:

BOD:

BDR:

RZE:

AOQ:

ALUD:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

CVJ:	135952412(Gpa2)

GFS:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AMAP:

AFUN:

AMOU:

AMRS:

AALI:

ACOS:

AAG:

AALB:

109401424 109432887 115257139

ASUA:

134212138 134216237

CQU:	CpipJ_CPIJ013236

CPII:

CNS:

BCOO:

LLL:

PPAP:

CCIN:

DSM:

NFB:

NLO:

NVG:

AROA:

TCA:	659603(Gpa2)

TMOL:

138126446(Gpa2)

DPA:

109546615

ESIM:

136418700(Gpa2)

EFOR:

136342882(Gpa2)

SOY:

AGRG:

ATD:

CSET:

HAXR:

AGB:

LDC:

DVV:

NVL:

DCOR:

APLN:

PPYR:

BMOR:

100174849(GPA2)

BMAN:

114244830

MSEX:

115453281

DPL:	KGM_208481

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

BPHI:

137932964(Gpa2)

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:	113497636 113506317

SLIU:

OFU:

ONU:

ATRA:

GMW:	113512620 128201873

PXY:

PGW:

LGLY:

CSTB:

CFEL:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

DCI:

CLEC:

HHAL:

106687348(Gpa2)

NLU:

111064632

HVI:

124357027

MQU:

128986686

PHU:	Phum_PHUM347260

FOC:

TPAL:

CSEC:

SGRE:

BROR:

IEL:

HAMR:

139697988(Gpa2)

FCD:

110846527

DPX:	DAPPUDRAFT_212447

DMK:

123471237

DPZ:

124336523

PVM:	113820144(Gpa2)

PJA:

PCHN:

PMOO:

HAME:

PCLA:

123761290(Gpa2)

CQD:	128691292(Gpa2)

PTRU:

123499281

ESN:

127008959

MNZ:

135222891

MRJ:	136847764(Gpa2)

PORN:

139762587(Gpa2)

HAZT:

PPOI:

ISC:

DSV:

RMP:

TUT:

DPTE:

DFR:

CSCU:

CVS:	136969353 136969647

PTEP:

107439088 139426428

ABRU:

129958789 129976157

UDV:

129217533

SDM:	118184469 118195289

LPOL:

106456882 106462792

CEL:	CELE_F58H1.4(gpla-1)

CBR:	CBG_23335(Cbr-flr-2)

CRQ:	GCK72_018145

NAI:	NECAME_17526

BMY:	BM_BM4568(Bma-flr-2)

LOA:	LOAG_07357

TSP:

Tsp_03807

LGI:	LOTGIDRAFT_161605

PVUL:

PCAN:

LSAX:

BGT:

GAE:

HCRA:

CANU:

CVN:

OED:

MYI:

PMAX:

AIRR:

MCAF:

RPHI:

MAEA:

LJP:

HSY:

Reference

PMID:12089349

Authors

Hsu SY, Nakabayashi K, Bhalla A

Title

Evolution of glycoprotein hormone subunit genes in bilateral metazoa: identification of two novel human glycoprotein hormone subunit family genes, GPA2 and GPB5.

Journal

Mol Endocrinol 16:1538-51 (2002)
DOI:10.1210/mend.16.7.0871

Reference

PMID:16376481

Authors

Breous E, Wenzel A, Loos U

Title

Promoter cloning and characterisation of the transcriptional regulation of the human thyrostimulin A2 subunit.

Journal

Mol Cell Endocrinol 245:169-80 (2005)
DOI:10.1016/j.mce.2005.11.009

Sequence

[hsa:170589]

LinkDB

DBGET integrated database retrieval system