KEGG   MODULE: M00127
Entry
M00127            Pathway   Module                                 
Name
Thiamine biosynthesis, prokaryotes, AIR (+ DXP/tyrosine) => TMP/TPP
Definition
K03148+K03154 K03151
K03150 K03149
K03147 ((K00941 K00788),K14153,K21219) K00946
Diagram
M00127

Orthology
K03148  
thiF; sulfur carrier protein ThiS adenylyltransferase [EC:2.7.7.73] [RN:R07459]
K03154  
thiS; sulfur carrier protein
K03151  
thiI; tRNA uracil 4-sulfurtransferase [EC:2.8.1.4] [RN:R07461]
K03150  
thiH; 2-iminoacetate synthase [EC:4.1.99.19] [RN:R10246]
K03149  
thiG; thiazole synthase [EC:2.8.1.10] [RN:R10247]
K03147  
thiC; phosphomethylpyrimidine synthase [EC:4.1.99.17] [RN:R03472]
K00941  
thiD; phosphomethylpyrimidine kinase [EC:2.7.4.7] [RN:R04509]
K00788  
thiE; thiamine-phosphate pyrophosphorylase [EC:2.5.1.3] [RN:R10712]
K14153,K21219  
thiDE,thiDN; phosphomethylpyrimidine kinase / thiamine-phosphate diphosphorylase [EC:2.7.4.7 2.5.1.3] [RN:R04509 R10712]
K00946  
thiL; thiamine-monophosphate kinase [EC:2.7.4.16] [RN:R00617]
Class
Pathway modules; Metabolism of cofactors and vitamins; Cofactor and vitamin metabolism
Pathway
map00730  Thiamine metabolism
map01240  Biosynthesis of cofactors
map01100  Metabolic pathways
Reaction
R07459  
R07461  
R10246  
R10247  
R09977  
R03472  
R04509  
R10712  
R00617  
Compound
C15810  Sulfur-carrier protein
C15813  Adenylyl-[sulfur-carrier protein]
C15814  Thiocarboxy-[sulfur-carrier protein]
C00082  L-Tyrosine
C15809  Iminoglycine
C11437  1-Deoxy-D-xylulose 5-phosphate
C20246  2-[(2R,5Z)-2-Carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate
C20247  2-(2-Carboxy-4-methylthiazol-5-yl)ethyl phosphate
C03373  Aminoimidazole ribotide
C04556  4-Amino-2-methyl-5-(phosphooxymethyl)pyrimidine
C04752  4-Amino-5-hydroxymethyl-2-methylpyrimidine diphosphate
C01081  Thiamin monophosphate
C00068  Thiamin diphosphate
Reference
PMID:10382260
  Authors
Begley TP, Downs DM, Ealick SE, McLafferty FW, Van Loon AP, Taylor S, Campobasso N, Chiu HJ, Kinsland C, Reddick JJ, Xi J
  Title
Thiamin biosynthesis in prokaryotes.
  Journal
Arch Microbiol 171:293-300 (1999)
DOI:10.1007/s002030050713
Reference
PMID:19348578
  Authors
Jurgenson CT, Begley TP, Ealick SE
  Title
The structural and biochemical foundations of thiamin biosynthesis.
  Journal
Annu Rev Biochem 78:569-603 (2009)
DOI:10.1146/annurev.biochem.78.072407.102340
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