KEGG   MODULE: M00847
Entry
M00847            Pathway   Module                                 
Name
Heme biosynthesis, archaea, siroheme => heme
Definition
K22225 K22226 (K22227,K25033)
Diagram
M00847  Heme biosynthesis, archaea, siroheme => heme
M00847

Class
Pathway modules; Metabolism of cofactors and vitamins; Cofactor and vitamin metabolism
Pathway
map00860  Porphyrin metabolism
map01240  Biosynthesis of cofactors
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Orthology
K22225  
ahbAB; siroheme decarboxylase [EC:4.1.1.111] [RN:R12000]
K22226  
ahbC; 12,18-didecarboxysiroheme decarboxylase [RN:R12001]
K22227  
ahbD; AdoMet-dependent heme synthase [EC:1.3.98.6] [RN:R12002]
K25033  
chdC; hydrogen peroxide-dependent heme synthase [EC:1.3.98.5] [RN:R11522]
Complete
dds  Desulfovibrio desulfuricans ATCC 27774
dfi  Desulfovibrio fairfieldensis
dpg  Desulfovibrio piger
def  Desulfovibrio sp. G11
dtr  Desulfovibrio trichonymphae
dfl  Desulfovibrio ferrophilus
psyf  Desulfovibrio mangrovi
dsb  Desulfovibrio subterraneus
delf  Desulfovibrio sp. 86
dfk  Desulfovibrio falkowii
dma  Solidesulfovibrio magneticus
dcb  Solidesulfovibrio carbinolicus
soli  Solidesulfovibrio sp. DCME
dgg  Megalodesulfovibrio gigas
dde  Oleidesulfovibrio alaskensis
dms  Oceanidesulfovibrio marinus
dsa  Maridesulfovibrio salexigens
dhy  Maridesulfovibrio hydrothermalis
daf  Desulfocurvibacter africanus subsp. africanus
das  Pseudodesulfovibrio aespoeensis
dpi  Pseudodesulfovibrio piezophilus
dej  Pseudodesulfovibrio indicus
pprf  Pseudodesulfovibrio profundus
psel  Pseudodesulfovibrio cashew
ddn  Pseudodesulfovibrio mercurii
psef  Pseudodesulfovibrio sediminis
ppor  Pseudodesulfovibrio portus
pnw  Pseudodesulfovibrio nedwellii
pthe  Pseudodesulfovibrio thermohalotolerans
pmen  Pseudodesulfovibrio methanolicus
lip  Lawsonia intracellularis PHE/MN1-00
lir  Lawsonia intracellularis N343
dsx  Desulfolutivibrio sulfoxidireducens
dsd  Desulfolutivibrio sulfodismutans
pbiz  Desulfobaculum bizertense
dvu  Nitratidesulfovibrio vulgaris Hildenborough
dvl  Nitratidesulfovibrio vulgaris DP4
dvm  Nitratidesulfovibrio vulgaris Miyazaki F
dvg  Nitratidesulfovibrio vulgaris RCH1
clih  Nitratidesulfovibrio liaohensis
tmur  Taurinivorans muris
bws  Bilophila wadsworthia
dba  Desulfomicrobium baculatum
doa  Desulfomicrobium orale
desu  Desulfomicrobium sp. ZS1
thew  Thermodesulfomicrobium sp. WS
drt  Desulfohalobium retbaense
dol  Desulfosudis oleivorans
dal  Desulfatibacillum aliphaticivorans
dat  Desulforapulum autotrophicum
dto  Desulfobacula toluolica
dhg  Desulfobacter hydrogenophilus
dov  Desulfosarcina ovata subsp. sediminis
dwd  Desulfosarcina widdelii
dalk  Desulfosarcina alkanivorans
dvr  Desulfosarcina variabilis
dml  Desulfococcus multivorans
dli  Desulfonema limicola
dmm  Desulfonema magnum
dek  Desulfoluna limicola
sat  Syntrophus aciditrophicus
sbus  Syntrophus buswellii
dao  Desulfobacca acetoxidans
dti  Desulfomonile tiedjei
sfu  Syntrophobacter fumaroxidans
dax  Desulfoglaeba alkanexedens
dmp  Desulfoferula mesophila
tid  Thermodesulfatator indicus
top  Thermodesulfobacterium geofontis
thet  Thermodesulfobacterium sp. TA1
cthi  Caldimicrobium thiodismutans
tav  Thermosulfuriphilus ammonigenes
tmai  Thermosulfurimonas marina
daw  Desulfofervidus auxilii
kst  Kuenenia stuttgartensis
broc  Brocadia sp. Ega_18-Q3-R5-49_MAXAC.112v2
bpit  Brocadia pituitae
jet  Jettenia sp.
alus  Anaerohalosphaera lusitana
taer  Tichowtungia aerotolerans
lbv  Lentisphaerota bacterium zth2
lbac  Lentisphaerae bacterium WC36
blr  Brevibacillus laterosporus
brw  Brevibacillus sp. 7WMA2
ppoy  Paenibacillus polymyxa Sb3-1
psab  Paenibacillus sabinae
pdu  Paenibacillus durus
pste  Paenibacillus stellifer
psop  Paenibacillus sophorae
pmae  Paenibacillus macerans
pacl  Paenibacillus sp. CAA11
paub  Paenibacillus sp. URB8-2
bts  Kyrpidia tusciae
kyr  Kyrpidia spormannii
cac  Clostridium acetobutylicum ATCC 824
cae  Clostridium acetobutylicum DSM 1731
cay  Clostridium acetobutylicum EA 2018
cbe  Clostridium beijerinckii NCIMB 8052
cbz  Clostridium beijerinckii ATCC 35702
cbei  Clostridium beijerinckii NCIMB 14988
ckl  Clostridium kluyveri DSM 555
ckr  Clostridium kluyveri NBRC 12016
csr  Clostridium saccharoperbutylacetonicum
cpas  Clostridium pasteurianum BC1
cpat  Clostridium pasteurianum DSM 525 = ATCC 6013
cpae  Clostridium pasteurianum DSM 525 = ATCC 6013
csq  Clostridium scatologenes
cck  Clostridium carboxidivorans
ctyk  Clostridium tyrobutyricum
ceu  Clostridium estertheticum
cdrk  Clostridium drakei
cdy  Clostridium diolis
crw  Clostridium felsineum DSM 7320
cfb  Clostridium felsineum DSM 794
caun  Clostridium felsineum DSM 793
cint  Clostridium intestinale
clom  Clostridium sp. MF28
cloo  Clostridium sp. OS1-26
swo  Syntrophomonas wolfei
slp  Syntrophothermus lipocalidus
salq  Syntrophocurvum alkaliphilum
dsy  Desulfitobacterium hafniense Y51
dhd  Desulfitobacterium hafniense DCB-2
ddh  Desulfitobacterium dehalogenans
ddl  Desulfitobacterium dichloroeliminans
dmt  Desulfitobacterium metallireducens
sgy  Syntrophobotulus glycolicus
dor  Desulfosporosinus orientis
dai  Desulfosporosinus acidiphilus
dmi  Desulfosporosinus meridiei
ded  Dehalobacter sp. DCA
dec  Dehalobacter sp. CF
drs  Dehalobacter restrictus
deha  Dehalobacter sp. CP
dca  Desulfotomaculum nigrificans
pth  Pelotomaculum thermopropionicum
drm  Desulforamulus reducens
dru  Desulforamulus ruminis
dfg  Desulforamulus ferrireducens
dae  Desulfofarcimen acetoxidans
dku  Desulfofundulus kuznetsovii
tfr  Thermanaerosceptrum fracticalcis
aacx  Acididesulfobacillus acetoxydans
tjr  Thermincola carboxydiphila
dgi  Desulfoscipio gibsoniae
hmo  Heliomicrobium modesticaldum
hcv  Heliorestis convoluta
amt  Alkaliphilus metalliredigens
cace  Andreesenella acetica
cfm  Andreesenella formicacetica
gfe  Geosporobacter ferrireducens
teb  Tepidibacter aestuarii
dau  Desulforudis audaxviator
adg  Ammonifex degensii
mta  Moorella thermoacetica ATCC 39073
mtho  Neomoorella thermoacetica DSM 521
mthz  Neomoorella thermoacetica DSM 2955
mhui  Neomoorella humiferrea
ncj  Neomoorella carbonis
nth  Natranaerobius thermophilus
ncd  Natranaerofaba carboxydovora
ssg  Selenomonas sputigena
sri  Selenomonas ruminantium subsp. lactilytica
sele  Selenomonas sp. oral taxon 478
selo  Selenomonas sp. oral taxon 136
selt  Selenomonas sp. oral taxon 920
sdia  Selenomonas dianae
stim  Selenomonas timonae
selm  Selenomonas sp. TAMA-11512
mfun  Megamonas funiformis
puf  Pelosinus sp. UFO1
pft  Pelosinus fermentans
mana  Methylomusa anaerophila
sted  Sporomusa termitida
ssph  Sporomusa sphaeroides
sova  Sporomusa ovata
ssid  Sporomusa silvacetica
sacv  Sporomusa acidovorans
scao  Sporomusa carbonis
sgbi  Anaerosinus gibii
calk  Contubernalis alkaliaceticus
ccu  Cryptobacterium curtum
ele  Eggerthella lenta
dly  Dehalogenimonas lykanthroporepellens
dfo  Dehalogenimonas formicexedens
dlf  Dehalogenimonas loeffleri
lmaj  Lucifugimonas marina
mox  Methylomirabilis oxygeniifera
schv  Sumerlaea chitinivorans
mba  Methanosarcina barkeri Fusaro
mby  Methanosarcina barkeri MS
mbw  Methanosarcina barkeri Wiesmoor
mbar  Methanosarcina barkeri 227
mbak  Methanosarcina barkeri 3
mac  Methanosarcina acetivorans
mma  Methanosarcina mazei Go1
mmaz  Methanosarcina mazei Tuc01
mmj  Methanosarcina mazei S-6
mmac  Methanosarcina mazei C16
mvc  Methanosarcina vacuolata
mek  Methanosarcina sp. Kolksee
mls  Methanosarcina lacustris
metm  Methanosarcina sp. MTP4
mef  Methanosarcina sp. WH1
meq  Methanosarcina sp. WWM596
msj  Methanosarcina siciliae C2J
msz  Methanosarcina siciliae HI350
msw  Methanosarcina siciliae T4/M
mthr  Methanosarcina thermophila TM-1
mthe  Methanosarcina thermophila CHTI-55
mhor  Methanosarcina horonobensis
mfz  Methanosarcina flavescens
mhab  Methanosarcina hadiensis
metw  Methanosarcina sp. 795
mmaj  Methanosarcina mangrovi
msds  Methanosarcina sediminis
mmet  Methanococcoides methylutens
melo  Methanococcoides orientis
mmh  Methanohalophilus mahii
mhaz  Methanohalophilus halophilus
mpot  Methanohalophilus portucalensis
mev  Methanohalobium evestigatum
mzh  Methanosalsum zhilinae
mpy  Methanolobus psychrophilus
mzi  Methanolobus zinderi
mmav  Methanolobus mangrovi
mseb  Methanolobus sediminis
mhz  Methanomethylovorans hollandica
mehf  Methanimicrococcus hongohii
mees  Methanimicrococcus stummii
mtp  Methanothrix thermoacetophila
mcj  Methanothrix soehngenii
mhi  Methanothrix harundinacea
mrtj  Methanospirillum purgamenti
mem  Methanoculleus marisnigri
mchk  Methanoculleus chikugoensis
msum  Methanoculleus submarinus
mbn  Methanoregula boonei
mpl  Methanosphaerula palustris
mjk  Methanospirare jalkutatii
hsl  Halobacterium salinarum R1
hanr  Halobacterium salinarum NRC-34001
hhb  Halobacterium hubeiense
hags  Halobacterium sp. GSL-19
habo  Halobacterium sp. BOL4-2
hno  Halobacterium noricense
hlu  Halobacterium litoreum
hanx  Halobacterium sp. NMX12-1
halr  Halarchaeum sp. CBA1220
hdo  Halococcus dombrowskii
sali  Salinarchaeum sp. Harcht-Bsk1
hara  Natranaeroarchaeum sulfidigenes
hma  Haloarcula marismortui ATCC 43049
hsin  Haloarcula marismortui ATCC 33800
hhi  Haloarcula hispanica ATCC 33960
hhn  Haloarcula hispanica N601
hab  Haloarcula sp. CBA1115
hta  Haloarcula taiwanensis
halj  Haloarcula sp. JP-L23
hmu  Halomicrobium mukohataei
halz  Halomicrobium mukohataei JP60
hall  Halomicrobium sp. LC1Hm
hazp  Halomicrobium sp. ZPS1
hali  Halorientalis sp. IM1011
hrr  Halosimplex rubrum
hpel  Halosimplex pelagicum
hlt  Halosimplex litoreum
harc  Halococcoides cellulosivorans
nph  Natronomonas pharaonis
nmo  Natronomonas moolapensis
nho  Natronomonas halophila
nsal  Natronomonas salina
hvo  Haloferax volcanii DS2
hale  Haloferax volcanii wsp1
hln  Haloferax volcanii SVX82
hme  Haloferax mediterranei
hgi  Haloferax gibbonsii
hls  Haloferax larsenii
hbo  Halogeometricum borinquense
hlm  Halobellus limi
hla  Halorubrum lacusprofundi
halp  Halorubrum sp. PV6
halb  Halorubrum sp. BOL3-1
hezz  Halorubrum ezzemoulense
halq  Halorubrum sp. CBA1229
hss  Halorubrum ruber
hsai  Halorubrum salinarum
hazz  Halorubrum sp. 2020YC2
hmp  Halobaculum magnesiiphilum
hre  Halobaculum roseum
hrm  Halobaculum rubrum
hacb  Halobaculum sp. CBA1158
htu  Haloterrigena turkmenica
hsal  Haloterrigena salifodinae
nat  Natrinema sp. J7-2
npe  Natrinema pellirubrum
nvr  Natrinema versiforme
npl  Natrinema pallidum
haly  Natrinema halophilum
hjt  Natrinema thermotolerans
hlo  Natrinema longum
sawl  Natronosalvus rutilus
halv  Natronosalvus halobius
nas  Natronorubrum aibiense
meam  Methanonatronarchaeum sp. AMET6-2
meae  Methanonatronarchaeum sp. AMET-Sl
 » show all
Reaction
R12000  
R12001  
R12002,R11522  
Compound
C00748  Siroheme
C21835  12,18-Didecarboxysiroheme
C21284  Fe-coproporphyrin III
C00032  Heme
Reference
PMID:24669201
  Authors
Kuhner M, Haufschildt K, Neumann A, Storbeck S, Streif J, Layer G
  Title
The alternative route to heme in the methanogenic archaeon Methanosarcina barkeri.
  Journal
Archaea 2014:327637 (2014)
DOI:10.1155/2014/327637
Reference
PMID:24865947
  Authors
Palmer DJ, Schroeder S, Lawrence AD, Deery E, Lobo SA, Saraiva LM, McLean KJ, Munro AW, Ferguson SJ, Pickersgill RW, Brown DG, Warren MJ
  Title
The structure, function and properties of sirohaem decarboxylase--an enzyme with structural homology to a transcription factor family that is part of the alternative haem biosynthesis pathway.
  Journal
Mol Microbiol 93:247-61 (2014)
DOI:10.1111/mmi.12656
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