KEGG   MODULE: M00847
Entry
M00847            Pathway   Module                                 
Name
Heme biosynthesis, archaea, siroheme => heme
Definition
K22225 K22226 (K22227,K25033)
Diagram
M00847

Orthology
K22225  
ahbAB; siroheme decarboxylase [EC:4.1.1.111] [RN:R12000]
K22226  
ahbC; 12,18-didecarboxysiroheme decarboxylase [RN:R12001]
K22227  
ahbD; AdoMet-dependent heme synthase [EC:1.3.98.6] [RN:R12002]
K25033  
chdC; hydrogen peroxide-dependent heme synthase [EC:1.3.98.5] [RN:R11522]
Class
Pathway modules; Metabolism of cofactors and vitamins; Cofactor and vitamin metabolism
Pathway
map00860  Porphyrin metabolism
map01240  Biosynthesis of cofactors
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Reaction
R12000  
R12001  
R12002,R11522  
Compound
C00748  Siroheme
C21835  12,18-Didecarboxysiroheme
C21284  Fe-coproporphyrin III
C00032  Heme
Reference
PMID:24669201
  Authors
Kuhner M, Haufschildt K, Neumann A, Storbeck S, Streif J, Layer G
  Title
The alternative route to heme in the methanogenic archaeon Methanosarcina barkeri.
  Journal
Archaea 2014:327637 (2014)
DOI:10.1155/2014/327637
Reference
PMID:24865947
  Authors
Palmer DJ, Schroeder S, Lawrence AD, Deery E, Lobo SA, Saraiva LM, McLean KJ, Munro AW, Ferguson SJ, Pickersgill RW, Brown DG, Warren MJ
  Title
The structure, function and properties of sirohaem decarboxylase--an enzyme with structural homology to a transcription factor family that is part of the alternative haem biosynthesis pathway.
  Journal
Mol Microbiol 93:247-61 (2014)
DOI:10.1111/mmi.12656
LinkDB

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