KEGG   MODULE: M00938
Entry
M00938            Pathway   Module                                 
Name
Pyrimidine deoxyribonucleotide biosynthesis, UDP => dTTP
Definition
(K00525+K00526,K10807+K10808) (K00940,K18533) K01520 (K00560,K13998,K03465) K00943
Diagram
M00938

Orthology
K00525,K00526,K10807,K10808  
ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1] [RN:R02018]
K00940,K18533  
nucleoside-diphosphate kinase [EC:2.7.4.6] [RN:R02331 R02093]
K01520  
dUTP pyrophosphatase [EC:3.6.1.23] [RN:R02100]
K00560,K13998  
thymidylate synthase [EC:2.1.1.45] [RN:R02101]
K03465  
thymidylate synthase (FAD) [EC:2.1.1.148] [RN:R06613]
K00943  
dTMP kinase [EC:2.7.4.9] [RN:R02094]
Class
Pathway modules; Nucleotide metabolism; Pyrimidine metabolism
Pathway
map00240  Pyrimidine metabolism
map01232  Nucleotide metabolism
map01100  Metabolic pathways
Reaction
R02018  
R02331  
R02100  
R02101,R06613  
R02094  
R02093  
Compound
C00015  UDP
C01346  dUDP
C00460  dUTP
C00365  dUMP
C00364  dTMP
C00363  dTDP
C00459  dTTP
Reference
PMID:28458037
  Authors
Okesli A, Khosla C, Bassik MC
  Title
Human pyrimidine nucleotide biosynthesis as a target for antiviral chemotherapy.
  Journal
Curr Opin Biotechnol 48:127-134 (2017)
DOI:10.1016/j.copbio.2017.03.010
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