KEGG   ORTHOLOGY: K13998
Entry
K13998                      KO                                     
Symbol
DHFR-TS
Name
dihydrofolate reductase / thymidylate synthase [EC:1.5.1.3 2.1.1.45]
Pathway
map00240  Pyrimidine metabolism
map00670  One carbon pool by folate
map00790  Folate biosynthesis
map01100  Metabolic pathways
map01232  Nucleotide metabolism
map01240  Biosynthesis of cofactors
Module
M00126  Tetrahydrofolate biosynthesis, GTP => THF
M00841  Tetrahydrofolate biosynthesis, mediated by PTPS, GTP => THF
M00938  Pyrimidine deoxyribonucleotide biosynthesis, UDP => dTTP
Reaction
R00936  5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase
R00937  5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase
R00939  5,6,7,8-tetrahydrofolate:NADP+ oxidoreductase
R00940  5,6,7,8-tetrahydrofolate:NADP+ oxidoreductase
R02101  5,10-methylenetetrahydrofolate:dUMP C-methyltransferase
R02235  dihydrofolate:NAD+ oxidoreductase
R02236  dihydrofolate:NADP+ oxidoreductase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00240 Pyrimidine metabolism
    K13998  DHFR-TS; dihydrofolate reductase / thymidylate synthase
  09108 Metabolism of cofactors and vitamins
   00790 Folate biosynthesis
    K13998  DHFR-TS; dihydrofolate reductase / thymidylate synthase
   00670 One carbon pool by folate
    K13998  DHFR-TS; dihydrofolate reductase / thymidylate synthase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.3  dihydrofolate reductase
     K13998  DHFR-TS; dihydrofolate reductase / thymidylate synthase
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.45  thymidylate synthase
     K13998  DHFR-TS; dihydrofolate reductase / thymidylate synthase
Other DBs
GO: 0004146 0004799
Genes
DPTE: 113798991
OSA: 4350527 9271078
OBR: 102699594 102706896
OGL: 127754870 127758176
BDI: 100832991
ATS: 109782258
TDC: 119356870 119366109
TAES: 123047147 123054960 123190811
TUA: 125540101
HVG: 123428176
LPER: 127299054 127307748 127337252
LRD: 124651986 124653628 124669467 124672258 124686829 124686834
SBI: 8068714
ZMA: 100286018 103644908 103653497 541707
MFLO: 136481906 136483752 136484999 136486805 136505104 136508437 136508568
SITA: 101772369 101778216
SVS: 117833345 117844780
PVIR: 120644352 120670599 120685347
PHAI: 112902480
PAUA: 133886948 133900423
CROT: 144568182
PDA: 103701887 103704597 120103784 120111890
EGU: 105046541 105048636
MUS: 135583478
ZOF: 121988359 122038701
DCT: 110095917 110107974
PEQ: 110030414
AOF: 109830591
ATH: AT2G16370(THY-1) AT2G21550 AT4G34570(THY-2)
ALY: 9305209 9316457 9322288
CRB: 17877840 17887860 17891157
CSAT: 104702701 104713608 104716677 104721335 104729758 104747430 104751813 104766934 104792357
EUS: EUTSA_v10000156mg EUTSA_v10022646mg EUTSA_v10024973mg
BRP: 103836808 103858399 103860451 103862355
BNA: 106354095 106384507 106393759 106406829 106442422 125575152
BOE: 106309714 106328327 106329435
RSZ: 108836084 108842569 108861958 130509264
THJ: 104807303 104819616 104824813
CIT: 102610005
CIC: CICLE_v10028191mg
PVY: 116127617
MINC: 123213144 123227647 123229278 123229303
TCC: 18591434 18607742
GRA: 105769038 105772952 105795321
GHI: 107905452 107908795 107927990 107928896 107937003 107960692
GAB: 108453978 108474386 108480725
HSYR: 120175428 120178255 120194709
DZI: 111282035 111296923
EGR: 104453306
RARG: 115737167 115738554
GMX: 100786311 100786329 100788658 547833(DHFR-TS)
GSJ: 114374890 114379844 114408452 114414471
PVU: 137820114 137830007
VRA: 106755099 106762733 106765682
VAR: 108324425 108331800 108338839
VUN: 114163394 114168580
VUM: 124828953 124831564 124837385
CCAJ: 109788871 109800919
APRC: 113864394 113864826
MTR: 11415341 11440565 25495385
TPRA: 123899206 123916149
CAM: 101489312 101514182
PSAT: 127083824 127106027
VVO: 131623512 131632237 131660403 131660409 131660447
LJA: 130729138 130747500
ADU: 107460028 107471889 107476648
AIP: 107610060 107623690 107628864
AHF: 112705584 112716796 112736912 112764559 112783199 112789171
LANG: 109344038 109355467
PCIN: 129289822 129292987
QSA: O6P43_001881 O6P43_011576
FVE: 101310472
AANS: 126782357
RCN: 112173264
PPER: 18768793
PMUM: 103335682
PAVI: 110768489
PDUL: 117636448
MDM: 103440375 103448418
MSYL: 126586977 126622017
PXB: 103967122
PCOX: 137725416 137728039
ZJU: 107403693 107405872
MNT: 21392108
CSAV: 115706733 115712098
HLP: 133798577 133822341
CSV: 101208660
CMO: 103499691
BHJ: 120088401
MCHA: 111015400
CMAX: 111484218 111499552
CMOS: 111448895 111451711
CPEP: 111777623 111794868
RCU: 8275764 8285348
MEAN: 126682214
JCU: 105630137
HBR: 110645146 110648723 110651614 110658623
MESC: 110606532 110613044 110626513
POP: 7456362 7470002 7477628
PEU: 105134685 105142240 105142730
PALZ: 118039734 118058921 118062116
PNZ: 133680285 133699991
JRE: 108983433 108986993 108991352
CILL: 122310717 122313275 122317474
CAVE: 132189920 132191371
AGLU: 133872031 133882221
QSU: 111986005 112011045
QLO: 115967528 115974377
CSAA: 142619100 142642912
TWL: 120002759 120013798
VVI: 100255872 100267529
VRI: 117906191 117911438 117911790
SLY: 101267455
SPEN: 107008381
SOT: 102593228
SSTN: 125873180
SDUL: 129885437
SVER: 125816649
CANN: 107840424
LBB: 132599188
NTA: 107792811 107794251 107796982
NSY: 104226167 104246758
NTO: 104105538
NAU: 109223692 109229673
INI: 109161459 109165210
ITR: 116030408 116032351
SIND: 105159256
OEU: 111388204 111401309 111410074
EGT: 105963185
SSPL: 121753989 121758822
SMIL: 130986590
APAN: 127265234
PEBU: 140819764
PTAB: 142520993
CARB: 113707866 113712498 113713534 140003885
HAN: 110900389 110929462
BHW: 143543696 143547140 143554567 143571461 143595568 143604881
ECAD: 122595924 122599620
LSV: 111908602(LOC111908602) 111918249(LOC111918249)
CCAV: 112500613 112516607
DCR: 108193031 108227144
AGRV: 141683339 141702352 141704797
CSIN: 114264669 114288633
RVL: 131307945 131319431
AEW: 130779880 130786646 130786973
DLT: 127802578 127802579 127804324
CFLO: 132276327 132300625
BVG: 104904324(LOC104904324)
SOE: 110803064
CQI: 110698439 110702982 110705118 110724197
CALB: 145560247(LOC145560247) 145589861(LOC145589861) 145621527(LOC145621527)
ATRI: 130809792 130815602
SLAF: 141599341 141605294 141648553
MOF: 131156495
NNU: 104595633
MING: 122063099
TSS: 122658701 122660413
PSOM: 113285996 113307581 113323259
MSIN: 131234405 131237929
ACAK: 137938832 137941061
NCOL: 116248449
ATR: 18437260
CJF: 131028859 131040783
SMO: SELMODRAFT_233517 SELMODRAFT_404548
PPP: 112291384
CRE: CHLRE_17g715900v5
VCN: VOLCADRAFT_66296
MNG: MNEG_15931
CSL: COCSUDRAFT_37014
CVR: CHLNCDRAFT_30873
APRO: F751_2439
OLU: OSTLU_49676
OTA: OT_ostta01g05920
BPG: Bathy03g03500
MIS: MICPUN_58650(DHFR-TS)
MPP: MICPUCDRAFT_56456(DHFR-TS)
CME: CYME_CMS462C
GSL: Gasu_03410
CCP: CHC_T00010030001
ACAN: ACA1_199730
PFA: PF3D7_0417200
PFD: PFDG_04158
PREI: PRSY57_0414700
PGAB: PGSY75_0417200
PLAG: 39740250(PADL01_0416400)
PYO: PY17X_0719300
PCB: PCHAS_0728300
PBE: 55149023
PVV: PVVCY_0701900
PKN: 7319328
PVX: PVX_089950
PCY: PCYB_053150
PMAL: PMUG01_05034700(DHFR-TS)
PBRS: 92369569(MKS88_001481)
PREL: PRELSG_0512500(DHFR-TS)
PCOT: PCOAH_00012090
TAN: TA08775
TPV: TP04_0504
TOT: TOT_040000412
BEQ: BEWA_008170
BBO: BBOV_II000780
BMIC: BMR1_02g03680
BBIG: BBBOND_0200560
CPV: cgd4_4460
CHO: Chro.40506
TGO: 7899539
BBES: BESB_004440
TET: TTHERM_00312120
PTM: GSPATT00019973001
PTI: PHATRDRAFT_1690
FCY: FRACYDRAFT_157897
TPS: THAPS_13647(TMS1)
AAF: AURANDRAFT_38942
PIF: PITG_06749
PSOJ: PHYSODRAFT_555231
BLAC: 94345841(CCR75_002070)
SPAR: SPRG_06761
TBR: Tb927.7.5480
TBG: TbgDal_VII6360
TCR: 509153.90
LMA: LMJF_06_0860(DHFR-TS)
LIF: LINJ_06_0890(DHFR-TS)
LDO: LDBPK_060890
LMI: LMXM_06_0860
LMAT: 92517853(LSCM1_07994)
LBZ: LBRM_06_0830
LPAN: LPMP_060820(DHFR-TS)
LOI: 92363604(LSCM4_07793)
LEIS: 94183348(GH5_08135)
LENR: 94174679(CUR178_07528)
LEIN: 94191359(JIQ42_07786)
PHET: 94293172(JKF63_07154)
NGR: NAEGRDRAFT_76251
EHX: EMIHUDRAFT_451981
GTT: GUITHDRAFT_69716
VG: 3655083(EhV113)
 » show all
Reference
PMID:8374616
  Authors
Lazar G, Zhang H, Goodman HM
  Title
The origin of the bifunctional dihydrofolate reductase-thymidylate synthase isogenes of Arabidopsis thaliana.
  Journal
Plant J 3:657-68 (1993)
DOI:10.1111/j.1365-313X.1993.00657.x
  Sequence
[ath:AT2G16370 AT4G34570]
Reference
PMID:8628226
  Authors
Schlichtherle IM, Roos DS, Van Houten JL
  Title
Cloning and molecular analysis of the bifunctional dihydrofolate reductase-thymidylate synthase gene in the ciliated protozoan Paramecium tetraurelia.
  Journal
Mol Gen Genet 250:665-73 (1996)
DOI:10.1007/BF02172977
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