KEGG   MODULE: M01022
Entry
M01022            Pathway   Module                                 
Name
dTDP-6-deoxy-L-Tal biosynthesis, Glc-1P => dTDP-6-deoxy-L-Tal
Definition
K00973 K01710 K01790 (K19180,K19652)
Diagram
M01022  dTDP-6-deoxy-L-Tal biosynthesis, Glc-1P => dTDP-6-deoxy-L-Tal
M01022

Class
Pathway modules; Glycan metabolism; Nucleotide sugar biosynthesis
Pathway
map00541  Biosynthesis of various nucleotide sugars
map00523  Polyketide sugar unit biosynthesis
map01250  Biosynthesis of nucleotide sugars
map01100  Metabolic pathways
Orthology
K00973  
rmlA; glucose-1-phosphate thymidylyltransferase [EC:2.7.7.24] [RN:R02328]
K01710  
rmlB; dTDP-glucose 4,6-dehydratase [EC:4.2.1.46] [RN:R06513]
K01790  
rmlC; dTDP-4-dehydrorhamnose 3,5-epimerase [EC:5.1.3.13] [RN:R06514]
K19180  
tll; dTDP-6-deoxy-L-talose 4-dehydrogenase (NAD+) [EC:1.1.1.339] [RN:R10190]
K19652  
tal; dTDP-6-deoxy-L-talose 4-dehydrogenase [NAD(P)+] [EC:1.1.1.344] [RN:R02776 R10190]
Complete
aat  Aggregatibacter actinomycetemcomitans D11S-1
sxt  Streptomyces xanthophaeus
ssir  Streptomyces sirii
kcm  Kitasatospora camelliae
58351  Kitasatospora kifunensis
mprn  Micromonospora profundi
Reaction
Compound
C00103  D-Glucose 1-phosphate
C00842  dTDP-glucose
C11907  dTDP-4-oxo-6-deoxy-D-glucose
C00688  dTDP-4-dehydro-beta-L-rhamnose
C03187  dTDP-6-deoxy-beta-L-talose
Reference
  Authors
Nakano Y, Suzuki N, Yoshida Y, Nezu T, Yamashita Y, Koga T
  Title
Thymidine diphosphate-6-deoxy-L-lyxo-4-hexulose reductase synthesizing dTDP-6-deoxy-L-talose from Actinobacillus actinomycetemcomitans.
  Journal
J Biol Chem 275:6806-12 (2000)
DOI:10.1074/jbc.275.10.6806
Reference
  Authors
Karki S, Yoo HG, Kwon SY, Suh JW, Kwon HJ
  Title
Cloning and in vitro characterization of dTDP-6-deoxy-L-talose biosynthetic genes from Kitasatospora kifunensis featuring the dTDP-6-deoxy-L-lyxo-4-hexulose reductase that synthesizes dTDP-6-deoxy-L-talose.
  Journal
Carbohydr Res 345:1958-62 (2010)
DOI:10.1016/j.carres.2010.07.004
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