KEGG   NETWORK: N00033
Entry
N00033                      Network                                
Name
EGF-EGFR-PI3K signaling pathway
Definition
EGF -> EGFR -> PI3K -> PIP3 -> AKT -| BAD
  Expanded
1950 -> 1956 -> (5290,5291,5293) -> C05981 -> (207,208,10000) -| 572
Class
nt06260 Colorectal cancer
nt06263 Hepatocellular carcinoma
nt06266 Non-small cell lung cancer
nt06270 Breast cancer
nt06273 Glioma
nt06276 Chronic myeloid leukemia
nt06214 PI3K signaling (cancer)
nt06162 Hepatitis B virus (HBV)
nt06163 Hepatitis C virus (HCV)
nt06170 Influenza A virus (IAV)
nt06165 Epstein-Barr virus (EBV)
nt06166 Human papillomavirus (HPV)
Type
Reference
Pathway
hsa04151  PI3K-Akt signaling pathway
Gene
1950  EGF; epidermal growth factor
1956  EGFR; epidermal growth factor receptor
5290  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
5291  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
5293  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
207  AKT1; AKT serine/threonine kinase 1
208  AKT2; AKT serine/threonine kinase 2
10000  AKT3; AKT serine/threonine kinase 3
572  BAD; BCL2 associated agonist of cell death
Metabolite
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:12040186
  Authors
Cantley LC
  Title
The phosphoinositide 3-kinase pathway.
  Journal
Science 296:1655-7 (2002)
DOI:10.1126/science.296.5573.1655
Reference
PMID:15784165
  Authors
Song G, Ouyang G, Bao S
  Title
The activation of Akt/PKB signaling pathway and cell survival.
  Journal
J Cell Mol Med 9:59-71 (2005)
DOI:10.1111/j.1582-4934.2005.tb00337.x
Reference
PMID:21620960
  Authors
Hers I, Vincent EE, Tavare JM
  Title
Akt signalling in health and disease.
  Journal
Cell Signal 23:1515-27 (2011)
DOI:10.1016/j.cellsig.2011.05.004
Reference
PMID:16341064
  Authors
Hennessy BT, Smith DL, Ram PT, Lu Y, Mills GB.
  Title
Exploiting the PI3K/AKT pathway for cancer drug discovery.
  Journal
Nat Rev Drug Discov 4:988-1004 (2005)
DOI:10.1038/nrd1902
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