KEGG   Homo sapiens (human): 5291
Entry
5291              CDS       T01001                                 
Symbol
PIK3CB, P110BETA, PI3K, PI3KBETA, PIK3C1
Name
(RefSeq) phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00562  Inositol phosphate metabolism
hsa01100  Metabolic pathways
hsa01521  EGFR tyrosine kinase inhibitor resistance
hsa01522  Endocrine resistance
hsa01524  Platinum drug resistance
hsa04012  ErbB signaling pathway
hsa04014  Ras signaling pathway
hsa04015  Rap1 signaling pathway
hsa04024  cAMP signaling pathway
hsa04062  Chemokine signaling pathway
hsa04066  HIF-1 signaling pathway
hsa04068  FoxO signaling pathway
hsa04070  Phosphatidylinositol signaling system
hsa04071  Sphingolipid signaling pathway
hsa04072  Phospholipase D signaling pathway
hsa04081  Hormone signaling
hsa04140  Autophagy - animal
hsa04150  mTOR signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa04152  AMPK signaling pathway
hsa04210  Apoptosis
hsa04211  Longevity regulating pathway
hsa04213  Longevity regulating pathway - multiple species
hsa04218  Cellular senescence
hsa04360  Axon guidance
hsa04370  VEGF signaling pathway
hsa04380  Osteoclast differentiation
hsa04510  Focal adhesion
hsa04550  Signaling pathways regulating pluripotency of stem cells
hsa04611  Platelet activation
hsa04613  Neutrophil extracellular trap formation
hsa04620  Toll-like receptor signaling pathway
hsa04625  C-type lectin receptor signaling pathway
hsa04630  JAK-STAT signaling pathway
hsa04650  Natural killer cell mediated cytotoxicity
hsa04660  T cell receptor signaling pathway
hsa04662  B cell receptor signaling pathway
hsa04664  Fc epsilon RI signaling pathway
hsa04666  Fc gamma R-mediated phagocytosis
hsa04668  TNF signaling pathway
hsa04670  Leukocyte transendothelial migration
hsa04722  Neurotrophin signaling pathway
hsa04725  Cholinergic synapse
hsa04750  Inflammatory mediator regulation of TRP channels
hsa04810  Regulation of actin cytoskeleton
hsa04910  Insulin signaling pathway
hsa04914  Progesterone-mediated oocyte maturation
hsa04915  Estrogen signaling pathway
hsa04917  Prolactin signaling pathway
hsa04919  Thyroid hormone signaling pathway
hsa04923  Regulation of lipolysis in adipocytes
hsa04926  Relaxin signaling pathway
hsa04929  GnRH secretion
hsa04930  Type II diabetes mellitus
hsa04931  Insulin resistance
hsa04932  Non-alcoholic fatty liver disease
hsa04933  AGE-RAGE signaling pathway in diabetic complications
hsa04935  Growth hormone synthesis, secretion and action
hsa04960  Aldosterone-regulated sodium reabsorption
hsa04973  Carbohydrate digestion and absorption
hsa05010  Alzheimer disease
hsa05017  Spinocerebellar ataxia
hsa05020  Prion disease
hsa05100  Bacterial invasion of epithelial cells
hsa05131  Shigellosis
hsa05132  Salmonella infection
hsa05135  Yersinia infection
hsa05142  Chagas disease
hsa05146  Amoebiasis
hsa05160  Hepatitis C
hsa05161  Hepatitis B
hsa05162  Measles
hsa05163  Human cytomegalovirus infection
hsa05164  Influenza A
hsa05165  Human papillomavirus infection
hsa05166  Human T-cell leukemia virus 1 infection
hsa05167  Kaposi sarcoma-associated herpesvirus infection
hsa05168  Herpes simplex virus 1 infection
hsa05169  Epstein-Barr virus infection
hsa05170  Human immunodeficiency virus 1 infection
hsa05171  Coronavirus disease - COVID-19
hsa05200  Pathways in cancer
hsa05203  Viral carcinogenesis
hsa05205  Proteoglycans in cancer
hsa05206  MicroRNAs in cancer
hsa05207  Chemical carcinogenesis - receptor activation
hsa05208  Chemical carcinogenesis - reactive oxygen species
hsa05210  Colorectal cancer
hsa05211  Renal cell carcinoma
hsa05212  Pancreatic cancer
hsa05213  Endometrial cancer
hsa05214  Glioma
hsa05215  Prostate cancer
hsa05218  Melanoma
hsa05220  Chronic myeloid leukemia
hsa05221  Acute myeloid leukemia
hsa05222  Small cell lung cancer
hsa05223  Non-small cell lung cancer
hsa05224  Breast cancer
hsa05225  Hepatocellular carcinoma
hsa05226  Gastric cancer
hsa05230  Central carbon metabolism in cancer
hsa05231  Choline metabolism in cancer
hsa05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
hsa05415  Diabetic cardiomyopathy
hsa05417  Lipid and atherosclerosis
hsa05418  Fluid shear stress and atherosclerosis
Network
nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06161  Human immunodeficiency virus 1 (HIV-1)
nt06162  Hepatitis B virus (HBV)
nt06163  Hepatitis C virus (HCV)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165  Epstein-Barr virus (EBV)
nt06166  Human papillomavirus (HPV)
nt06167  Human cytomegalovirus (HCMV)
nt06168  Herpes simplex virus 1 (HSV-1)
nt06169  Measles virus (MV)
nt06170  Influenza A virus (IAV)
nt06181  Salmonella
nt06182  Shigella
nt06214  PI3K signaling (cancer)
nt06260  Colorectal cancer
nt06261  Gastric cancer
nt06262  Pancreatic cancer
nt06263  Hepatocellular carcinoma
nt06264  Renal cell carcinoma
nt06266  Non-small cell lung cancer
nt06268  Melanoma
nt06270  Breast cancer
nt06273  Glioma
nt06275  Acute myeloid leukemia
nt06276  Chronic myeloid leukemia
nt06325  Hormone/cytokine signaling
nt06462  Spinocerebellar ataxia
nt06464  Amyotrophic lateral sclerosis
nt06465  Prion disease
nt06530  PI3K signaling
nt06533  Chemokine signaling
nt06537  TCR/BCR signaling
nt06541  Cytoskeleton in neurons
nt06543  NRG-ERBB signaling
  Element
N00030  EGF-EGFR-RAS-PI3K signaling pathway
N00031  Duplication or mutation-activated FLT3 to RAS-PI3K signaling pathway
N00032  Mutation-activated KRAS/NRAS to PI3K signaling pathway
N00033  EGF-EGFR-PI3K signaling pathway
N00034  ERBB2-overexpression to PI3K signaling pathway
N00035  Amplified EGFR to PI3K signaling pathway
N00036  Mutation-activated EGFR to PI3K signaling pathway
N00037  FGF-FGFR-PI3K signaling pathway
N00038  Amplified FGFR to PI3K signaling pathway
N00039  PDGF-PDGFR-PI3K signaling pathway
N00040  Amplified PDGFR to PI3K signaling pathway
N00042  EGFR-overexpression to PI3K signaling pathway
N00043  HGF-MET-PI3K signaling pathway
N00044  Mutation-activated MET to PI3K signaling pathway
N00045  KITLG-KIT-PI3K signaling pathway
N00046  Mutation-activated KIT to PI3K signaling pathway
N00047  EML4-ALK fusion kinase to PI3K signaling pathway
N00048  BCR-ABL fusion kinase to PI3K signaling pathway
N00159  KSHV K1 to PI3K signaling pathway
N00179  KSHV K1 to PI3K-NFKB signaling pathway
N00182  IGF-IGFR-PI3K-NFKB signaling pathway
N00218  FLT3LG-FLT3-RAS-PI3K signaling pathway
N00231  TGFA-EGFR-PI3K signaling pathway
N00232  TGFA-overexpression to PI3K signaling pathway
N00234  IGF2-IGF1R-PI3K signaling pathway
N00236  IGF2-overexpression to PI3K signaling pathway
N00238  IGF1R-overexpression to PI3K signaling pathway
N00247  HGF-overexpression to PI3K signaling pathway
N00249  MET-overexpression to PI3K signaling pathway
N00253  Amplified ERBB2 to PI3K signaling pathway
N00260  Amplified MET to PI3K signaling pathway
N00266  EBV LMP2A to PI3K signaling pathway
N00267  HBV HBx to PI3K signaling pathway
N00272  HCV NS5A to PI3K signaling pathway
N00281  EGF-overexpression to PI3K signaling pathway
N00282  EREG-EGFR-PI3K signaling pathway
N00283  EREG-overexpression to PI3K signaling pathway
N00284  AREG-EGFR-PI3K signaling pathway
N00285  AREG-overexpression to PI3K signaling pathway
N00387  HCMV IE1-72/IE2-86 to PI3K signaling pathway
N00390  EGF-EGFR-PI3K-NFKB signaling pathway
N00399  CCR2-GNB/G-PI3K-NFKB signaling pathway
N00430  CXCR4-GNAI-PI3K-BAD signaling pathway
N00485  EBV LMP1 to PI3K signaling pathway
N00501  HTLV-1 Tax to EGFR-PI3K-NFKB signaling pathway
N00514  Mutation-activated EGFR to PI3K signaling pathway
N00582  IGF-IGF1R-PI3K signaling pathway
N00583  HSV VP11/12 to PI3K signaling pathway
N00683  CD80/CD86-CD28-PI3K signaling pathway
N00684  MV F/H to CD28-PI3K signaling pathway
N00736  IAV NS1 to PI3K signaling pathway
N00963  RELN-VLDLR-PI3K signaling pathway
N00964  DAB1-overexpression to RELN-VLDLR-PI3K signaling pathway
N01063  Mutation-activated MET to PI3K signaling pathway
N01065  Mutation-activated RET to PI3K signaling pathway
N01067  Shigella IpgD to ARNO-ARF-ACTB_G signaling pathway
N01129  Salmonella SopB to ARNO-ARF-ACTB/G signaling pathway
N01163  NRG-ERBB4-PI3K signaling pathway
N01204  PRNP-PI3K-NOX2 signaling pathway
N01205  Scrapie conformation PrPSc to PRNP-PI3K-NOX2 signaling pathway
N01338  ACH-CHRN-PI3K signaling pathway
N01339  NNK/NNN to PI3K signaling pathway
N01347  EP/NE-ADRB-PI3K signaling pathway
N01348  Nicotine/NNK to PI3K signaling pathway
N01349  ACH-CHRN-PI3K signaling pathway
N01350  NNK/NNN to PI3K signaling pathway
N01355  Arsenic to PI3K signaling pathway
N01356  Membrane-initiated progesterone signaling pathway
N01357  P4/MPA to membrane-initiated progesterone signaling pathway
N01358  P4-PR-PI3K signaling pathway
N01359  P4/MPA to PR-PI3K signaling pathway
N01656  GF-RTK-PI3K signaling pathway
N01658  GF-RTK-RAS-PI3K signaling pathway
N01708  INS-AKT signaling pathway
N01770  CCR2-GNB/G-PI3K signaling pathway
N01858  EFNB1-MAPT axon guidance signaling
N01875  NRG-ERBB2/ERBB3 pathway (P13K signaling)
Drug target
Apitolisib: D10543
Bimiralisib: D11440
Buparlisib (DG01823): D10584 D10609
Dactolisib (DG01826): D10552 D10616
Gedatolisib: D10635
Leniolisib (DG02927): D11158
Omipalisib: D10718
Pictilisib: D10189
Samotolisib: D11501
Taselisib: D11774
Voxtalisib: D11727
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    5291 (PIK3CB)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    5291 (PIK3CB)
   04014 Ras signaling pathway
    5291 (PIK3CB)
   04015 Rap1 signaling pathway
    5291 (PIK3CB)
   04370 VEGF signaling pathway
    5291 (PIK3CB)
   04630 JAK-STAT signaling pathway
    5291 (PIK3CB)
   04668 TNF signaling pathway
    5291 (PIK3CB)
   04066 HIF-1 signaling pathway
    5291 (PIK3CB)
   04068 FoxO signaling pathway
    5291 (PIK3CB)
   04070 Phosphatidylinositol signaling system
    5291 (PIK3CB)
   04072 Phospholipase D signaling pathway
    5291 (PIK3CB)
   04071 Sphingolipid signaling pathway
    5291 (PIK3CB)
   04024 cAMP signaling pathway
    5291 (PIK3CB)
   04151 PI3K-Akt signaling pathway
    5291 (PIK3CB)
   04152 AMPK signaling pathway
    5291 (PIK3CB)
   04150 mTOR signaling pathway
    5291 (PIK3CB)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    5291 (PIK3CB)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    5291 (PIK3CB)
  09143 Cell growth and death
   04210 Apoptosis
    5291 (PIK3CB)
   04218 Cellular senescence
    5291 (PIK3CB)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    5291 (PIK3CB)
   04550 Signaling pathways regulating pluripotency of stem cells
    5291 (PIK3CB)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    5291 (PIK3CB)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    5291 (PIK3CB)
   04613 Neutrophil extracellular trap formation
    5291 (PIK3CB)
   04620 Toll-like receptor signaling pathway
    5291 (PIK3CB)
   04625 C-type lectin receptor signaling pathway
    5291 (PIK3CB)
   04650 Natural killer cell mediated cytotoxicity
    5291 (PIK3CB)
   04660 T cell receptor signaling pathway
    5291 (PIK3CB)
   04662 B cell receptor signaling pathway
    5291 (PIK3CB)
   04664 Fc epsilon RI signaling pathway
    5291 (PIK3CB)
   04666 Fc gamma R-mediated phagocytosis
    5291 (PIK3CB)
   04670 Leukocyte transendothelial migration
    5291 (PIK3CB)
   04062 Chemokine signaling pathway
    5291 (PIK3CB)
  09152 Endocrine system
   04910 Insulin signaling pathway
    5291 (PIK3CB)
   04923 Regulation of lipolysis in adipocytes
    5291 (PIK3CB)
   04929 GnRH secretion
    5291 (PIK3CB)
   04915 Estrogen signaling pathway
    5291 (PIK3CB)
   04914 Progesterone-mediated oocyte maturation
    5291 (PIK3CB)
   04917 Prolactin signaling pathway
    5291 (PIK3CB)
   04926 Relaxin signaling pathway
    5291 (PIK3CB)
   04935 Growth hormone synthesis, secretion and action
    5291 (PIK3CB)
   04919 Thyroid hormone signaling pathway
    5291 (PIK3CB)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    5291 (PIK3CB)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    5291 (PIK3CB)
  09156 Nervous system
   04725 Cholinergic synapse
    5291 (PIK3CB)
   04722 Neurotrophin signaling pathway
    5291 (PIK3CB)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    5291 (PIK3CB)
  09158 Development and regeneration
   04360 Axon guidance
    5291 (PIK3CB)
   04380 Osteoclast differentiation
    5291 (PIK3CB)
  09149 Aging
   04211 Longevity regulating pathway
    5291 (PIK3CB)
   04213 Longevity regulating pathway - multiple species
    5291 (PIK3CB)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    5291 (PIK3CB)
   05206 MicroRNAs in cancer
    5291 (PIK3CB)
   05205 Proteoglycans in cancer
    5291 (PIK3CB)
   05207 Chemical carcinogenesis - receptor activation
    5291 (PIK3CB)
   05208 Chemical carcinogenesis - reactive oxygen species
    5291 (PIK3CB)
   05203 Viral carcinogenesis
    5291 (PIK3CB)
   05230 Central carbon metabolism in cancer
    5291 (PIK3CB)
   05231 Choline metabolism in cancer
    5291 (PIK3CB)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    5291 (PIK3CB)
  09162 Cancer: specific types
   05210 Colorectal cancer
    5291 (PIK3CB)
   05212 Pancreatic cancer
    5291 (PIK3CB)
   05225 Hepatocellular carcinoma
    5291 (PIK3CB)
   05226 Gastric cancer
    5291 (PIK3CB)
   05214 Glioma
    5291 (PIK3CB)
   05221 Acute myeloid leukemia
    5291 (PIK3CB)
   05220 Chronic myeloid leukemia
    5291 (PIK3CB)
   05218 Melanoma
    5291 (PIK3CB)
   05211 Renal cell carcinoma
    5291 (PIK3CB)
   05215 Prostate cancer
    5291 (PIK3CB)
   05213 Endometrial cancer
    5291 (PIK3CB)
   05224 Breast cancer
    5291 (PIK3CB)
   05222 Small cell lung cancer
    5291 (PIK3CB)
   05223 Non-small cell lung cancer
    5291 (PIK3CB)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    5291 (PIK3CB)
   05170 Human immunodeficiency virus 1 infection
    5291 (PIK3CB)
   05161 Hepatitis B
    5291 (PIK3CB)
   05160 Hepatitis C
    5291 (PIK3CB)
   05171 Coronavirus disease - COVID-19
    5291 (PIK3CB)
   05164 Influenza A
    5291 (PIK3CB)
   05162 Measles
    5291 (PIK3CB)
   05168 Herpes simplex virus 1 infection
    5291 (PIK3CB)
   05163 Human cytomegalovirus infection
    5291 (PIK3CB)
   05167 Kaposi sarcoma-associated herpesvirus infection
    5291 (PIK3CB)
   05169 Epstein-Barr virus infection
    5291 (PIK3CB)
   05165 Human papillomavirus infection
    5291 (PIK3CB)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    5291 (PIK3CB)
   05131 Shigellosis
    5291 (PIK3CB)
   05135 Yersinia infection
    5291 (PIK3CB)
   05100 Bacterial invasion of epithelial cells
    5291 (PIK3CB)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    5291 (PIK3CB)
   05142 Chagas disease
    5291 (PIK3CB)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    5291 (PIK3CB)
   05017 Spinocerebellar ataxia
    5291 (PIK3CB)
   05020 Prion disease
    5291 (PIK3CB)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    5291 (PIK3CB)
   05418 Fluid shear stress and atherosclerosis
    5291 (PIK3CB)
   05415 Diabetic cardiomyopathy
    5291 (PIK3CB)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    5291 (PIK3CB)
   04932 Non-alcoholic fatty liver disease
    5291 (PIK3CB)
   04931 Insulin resistance
    5291 (PIK3CB)
   04933 AGE-RAGE signaling pathway in diabetic complications
    5291 (PIK3CB)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    5291 (PIK3CB)
   01524 Platinum drug resistance
    5291 (PIK3CB)
   01522 Endocrine resistance
    5291 (PIK3CB)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    5291 (PIK3CB)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     5291 (PIK3CB)
Membrane trafficking [BR:hsa04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    5291 (PIK3CB)
SSDB
Motif
Pfam: PI3_PI4_kinase PI3Ka PI3K_rbd PI3K_p85B PI3K_C2 Tom37_C DUF4381
Other DBs
NCBI-GeneID: 5291
NCBI-ProteinID: NP_006210
OMIM: 602925
HGNC: 8976
Ensembl: ENSG00000051382
UniProt: P42338
LinkDB
Position
3:complement(138652698..138834928)
AA seq 1070 aa
MCFSFIMPPAMADILDIWAVDSQIASDGSIPVDFLLPTGIYIQLEVPREATISYIKQMLW
KQVHNYPMFNLLMDIDSYMFACVNQTAVYEELEDETRRLCDVRPFLPVLKLVTRSCDPGE
KLDSKIGVLIGKGLHEFDSLKDPEVNEFRRKMRKFSEEKILSLVGLSWMDWLKQTYPPEH
EPSIPENLEDKLYGGKLIVAVHFENCQDVFSFQVSPNMNPIKVNELAIQKRLTIHGKEDE
VSPYDYVLQVSGRVEYVFGDHPLIQFQYIRNCVMNRALPHFILVECCKIKKMYEQEMIAI
EAAINRNSSNLPLPLPPKKTRIISHVWENNNPFQIVLVKGNKLNTEETVKVHVRAGLFHG
TELLCKTIVSSEVSGKNDHIWNEPLEFDINICDLPRMARLCFAVYAVLDKVKTKKSTKTI
NPSKYQTIRKAGKVHYPVAWVNTMVFDFKGQLRTGDIILHSWSSFPDELEEMLNPMGTVQ
TNPYTENATALHVKFPENKKQPYYYPPFDKIIEKAAEIASSDSANVSSRGGKKFLPVLKE
ILDRDPLSQLCENEMDLIWTLRQDCREIFPQSLPKLLLSIKWNKLEDVAQLQALLQIWPK
LPPREALELLDFNYPDQYVREYAVGCLRQMSDEELSQYLLQLVQVLKYEPFLDCALSRFL
LERALGNRRIGQFLFWHLRSEVHIPAVSVQFGVILEAYCRGSVGHMKVLSKQVEALNKLK
TLNSLIKLNAVKLNRAKGKEAMHTCLKQSAYREALSDLQSPLNPCVILSELYVEKCKYMD
SKMKPLWLVYNNKVFGEDSVGVIFKNGDDLRQDMLTLQMLRLMDLLWKEAGLDLRMLPYG
CLATGDRSGLIEVVSTSETIADIQLNSSNVAAAAAFNKDALLNWLKEYNSGDDLDRAIEE
FTLSCAGYCVASYVLGIGDRHSDNIMVKKTGQLFHIDFGHILGNFKSKFGIKRERVPFIL
TYDFIHVIQQGKTGNTEKFGRFRQCCEDAYLILRRHGNLFITLFALMLTAGLPELTSVKD
IQYLKDSLALGKSEEEALKQFKQKFDEALRESWTTKVNWMAHTVRKDYRS
NT seq 3213 nt   +upstreamnt  +downstreamnt
atgtgcttcagtttcataatgcctcctgctatggcagacatccttgacatctgggcggtg
gattcacagatagcatctgatggctccatacctgtggatttccttttgcccactgggatt
tatatccagttggaggtacctcgggaagctaccatttcttatattaagcagatgttatgg
aagcaagttcacaattacccaatgttcaacctccttatggatattgactcctatatgttt
gcatgtgtgaatcagactgctgtatatgaggagcttgaagatgaaacacgaagactctgt
gatgtcagaccttttcttccagttctcaaattagtgacaagaagttgtgacccaggggaa
aaattagactcaaaaattggagtccttataggaaaaggtctgcatgaatttgattccttg
aaggatcctgaagtaaatgaatttcgaagaaaaatgcgcaaattcagcgaggaaaaaatc
ctgtcacttgtgggattgtcttggatggactggctaaaacaaacatatccaccagagcat
gaaccatccatccctgaaaacttagaagataaactttatgggggaaagctcatcgtagct
gttcattttgaaaactgccaggacgtgtttagctttcaagtgtctcctaatatgaatcct
atcaaagtaaatgaattggcaatccaaaaacgtttgactattcatgggaaggaagatgaa
gttagcccctatgattatgtgttgcaagtcagcgggagagtagaatatgtttttggtgat
catccactaattcagttccagtatatccggaactgtgtgatgaacagagccctgccccat
tttatacttgtggaatgctgcaagatcaagaaaatgtatgaacaagaaatgattgccata
gaggctgccataaatcgaaattcatctaatcttcctcttccattaccaccaaagaaaaca
cgaattatttctcatgtttgggaaaataacaaccctttccaaattgtcttggttaaggga
aataaacttaacacagaggaaactgtaaaagttcatgtcagggctggtctttttcatggt
actgagctcctgtgtaaaaccatcgtaagctcagaggtatcagggaaaaatgatcatatt
tggaatgaaccactggaatttgatattaatatttgtgacttaccaagaatggctcgatta
tgttttgctgtttatgcagttttggataaagtaaaaacgaagaaatcaacgaaaactatt
aatccctctaaatatcagaccatcaggaaagctggaaaagtgcattatcctgtagcgtgg
gtaaatacgatggtttttgactttaaaggacaattgagaactggagacataatattacac
agctggtcttcatttcctgatgaactcgaagaaatgttgaatccaatgggaactgttcaa
acaaatccatatactgaaaatgcaacagctttgcatgttaaatttccagagaataaaaaa
caaccttattattaccctcccttcgataagattattgaaaaggcagctgagattgcaagc
agtgatagtgctaatgtgtcaagtcgaggtggaaaaaagtttcttcctgtattgaaagaa
atcttggacagggatcccttgtctcaactgtgtgaaaatgaaatggatcttatttggact
ttgcgacaagactgccgagagattttcccacaatcactgccaaaattactgctgtcaatc
aagtggaataaacttgaggatgttgctcagcttcaggcgctgcttcagatttggcctaaa
ctgcccccccgggaggccctagagcttctggatttcaactatccagaccagtacgttcga
gaatatgctgtaggctgcctgcgacagatgagtgatgaagaactttctcaatatctttta
caactggtgcaagtgttaaaatatgagccttttcttgattgtgccctctctagattccta
ttagaaagagcacttggtaatcggaggatagggcagtttctattttggcatcttaggtca
gaagtgcacattcctgctgtctcagtacaatttggtgtcatccttgaagcatactgccgg
ggaagtgtggggcacatgaaagtgctttctaagcaggttgaagcactcaataagttaaaa
actttaaatagtttaatcaaactgaatgccgtgaagttaaacagagccaaagggaaggag
gccatgcatacctgtttaaaacagagtgcttaccgggaagccctctctgacctgcagtca
cccctgaacccatgtgttatcctctcagaactctatgttgaaaagtgcaaatacatggat
tccaaaatgaagcctttgtggctggtatacaataacaaggtatttggtgaggattcagtt
ggagtgatttttaaaaatggtgatgatttacgacaggatatgttgacactccaaatgttg
cgcttgatggatttactctggaaagaagctggtttggatcttcggatgttgccttatggc
tgtttagcaacaggagatcgctctggcctcattgaagttgtgagcacctctgaaacaatt
gctgacattcagctgaacagtagcaatgtggctgctgcagcagccttcaacaaagatgcc
cttctgaactggcttaaagaatacaactctggggatgacctggaccgagccattgaggaa
tttacactgtcctgtgctggctactgtgtagcttcttatgtccttgggattggtgacaga
catagtgacaacatcatggtcaaaaaaactggccagctcttccacattgactttggacat
attcttggaaatttcaaatctaagtttggcattaaaagggagcgagtgccttttattctt
acctatgatttcatccatgtcattcaacaaggaaaaacaggaaatacagaaaagtttggc
cggttccgccagtgttgtgaggatgcatatctgattttacgacggcatgggaatctcttc
atcactctctttgcgctgatgttgactgcagggcttcctgaactcacatcagtcaaagat
atacagtatcttaaggactctcttgcattagggaagagtgaagaagaagcactcaaacag
tttaagcaaaaatttgatgaggcgctcagggaaagctggactactaaagtgaactggatg
gcccacacagttcggaaagactacagatcttaa

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