KEGG   NETWORK: N00034
Entry
N00034                      Network                                
Name
ERBB2-overexpression to PI3K signaling pathway
Definition
EGF -> (ERBB2*+EGFR) -> PI3K -> PIP3 -> AKT -> MTOR -> S6K
  Expanded
1950 -> (2064v1+1956) -> (5290,5291,5293) -> C05981 -> (207,208,10000) -> 2475 -> (6198,6199)
Class
nt06262 Pancreatic cancer
nt06270 Breast cancer
nt06214 PI3K signaling (cancer)
Type
Variant
Pathway
hsa05224  Breast cancer
hsa05212  Pancreatic cancer
Disease
H00031  Breast cancer
H00019  Pancreatic cancer
Gene
1950  EGF; epidermal growth factor
2064  ERBB2; erb-b2 receptor tyrosine kinase 2
1956  EGFR; epidermal growth factor receptor
5290  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
5291  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
5293  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
207  AKT1; AKT serine/threonine kinase 1
208  AKT2; AKT serine/threonine kinase 2
10000  AKT3; AKT serine/threonine kinase 3
2475  MTOR; mechanistic target of rapamycin
6198  RPS6KB1; ribosomal protein S6 kinase B1
6199  RPS6KB2; ribosomal protein S6 kinase B2
Variant
2064v1 (ERBB2*)  ERBB2 overexpression
Metabolite
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:22178455
  Authors
Eroles P, Bosch A, Perez-Fidalgo JA, Lluch A
  Title
Molecular biology in breast cancer: intrinsic subtypes and signaling pathways.
  Journal
Cancer Treat Rev 38:698-707 (2012)
DOI:10.1016/j.ctrv.2011.11.005
Reference
PMID:25544707
  Authors
Dittrich A, Gautrey H, Browell D, Tyson-Capper A
  Title
The HER2 Signaling Network in Breast Cancer--Like a Spider in its Web.
  Journal
J Mammary Gland Biol Neoplasia 19:253-70 (2014)
DOI:10.1007/s10911-014-9329-5
Reference
PMID:24649067
  Authors
Zhang MH, Man HT, Zhao XD, Dong N, Ma SL
  Title
Estrogen receptor-positive breast cancer molecular signatures and therapeutic potentials (Review).
  Journal
Biomed Rep 2:41-52 (2014)
DOI:10.3892/br.2013.187
Reference
PMID:23340292
  Authors
Chang Z, Li Z, Wang X, Kang Y, Yuan Y, Niu J, Wang H, Chatterjee D, Fleming JB, Li M, Abbruzzese JL, Chiao PJ
  Title
Deciphering the mechanisms of tumorigenesis in human pancreatic ductal epithelial cells.
  Journal
Clin Cancer Res 19:549-59 (2013)
DOI:10.1158/1078-0432.CCR-12-0032
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