| Entry |
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| Name |
Mutation-inactivated PTEN to PI3K signaling pathway
|
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| Definition |
PTEN* // PIP3 -> AKT |
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| Expanded |
5728v2 // C05981 -> (207,208,10000) |
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| Class |
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| Type |
Variant
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| Pathway |
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| Disease |
| H00048 | Hepatocellular carcinoma |
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| Gene |
| 5728 | PTEN; phosphatase and tensin homolog |
| 207 | AKT1; AKT serine/threonine kinase 1 |
| 208 | AKT2; AKT serine/threonine kinase 2 |
| 10000 | AKT3; AKT serine/threonine kinase 3 |
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| Variant |
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| Metabolite |
| C05981 | Phosphatidylinositol-3,4,5-trisphosphate |
|
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| Reference |
|
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| Authors |
Chalhoub N, Baker SJ |
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| Title |
PTEN and the PI3-kinase pathway in cancer. |
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| Journal |
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| Reference |
|
|---|
| Authors |
Zhu Y, Parada LF. |
|---|
| Title |
The molecular and genetic basis of neurological tumours. |
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| Journal |
|
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| Reference |
|
|---|
| Authors |
Knobbe CB, Merlo A, Reifenberger G. |
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| Title |
Pten signaling in gliomas. |
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| Journal |
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| Reference |
|
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| Authors |
Curtin JA, Fridlyand J, Kageshita T, Patel HN, Busam KJ, Kutzner H, Cho KH, Aiba S, Brocker EB, LeBoit PE, Pinkel D, Bastian BC |
|---|
| Title |
Distinct sets of genetic alterations in melanoma. |
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| Journal |
|
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| Reference |
|
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| Authors |
Miller AJ, Mihm MC Jr. |
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| Title |
Melanoma. |
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| Journal |
|
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| Reference |
|
|---|
| Authors |
Whittaker S, Marais R, Zhu AX |
|---|
| Title |
The role of signaling pathways in the development and treatment of hepatocellular carcinoma. |
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| Journal |
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| LinkDB |
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