Entry |
|
Name |
Mutation-activated CTNNB1 to Wnt signaling pathway
|
Definition |
(GSK3B+AXIN+APC) // CTNNB1* -> TCF/LEF => (BIRC5,MYC,CCND1) |
Expanded |
(2932+(8312,8313)+324) // 1499v1 -> (6932,83439,6934,51176) => (332,4609,595) |
Class |
|
Type |
Variant
|
Pathway |
|
Disease |
H00048 | Hepatocellular carcinoma |
|
Gene |
2932 | GSK3B; glycogen synthase kinase 3 beta |
324 | APC; APC, WNT signaling pathway regulator |
1499 | CTNNB1; catenin beta 1 |
6932 | TCF7; transcription factor 7 |
83439 | TCF7L1; transcription factor 7 like 1 |
6934 | TCF7L2; transcription factor 7 like 2 |
51176 | LEF1; lymphoid enhancer binding factor 1 |
332 | BIRC5; baculoviral IAP repeat containing 5 |
4609 | MYC; MYC proto-oncogene, bHLH transcription factor |
|
Variant |
1499v1 (CTNNB1*) CTNNB1 mutation
|
Reference |
|
Authors |
Polakis P |
Title |
Wnt signaling in cancer. |
Journal |
|
Reference |
|
Authors |
Duchartre Y, Kim YM, Kahn M |
Title |
The Wnt signaling pathway in cancer. |
Journal |
|
Reference |
|
Authors |
Takebe N, Harris PJ, Warren RQ, Ivy SP |
Title |
Targeting cancer stem cells by inhibiting Wnt, Notch, and Hedgehog pathways. |
Journal |
|
Reference |
|
Authors |
Takayama T, Miyanishi K, Hayashi T, Sato Y, Niitsu Y. |
Title |
Colorectal cancer: genetics of development and metastasis. |
Journal |
|
Reference |
|
Authors |
Giles RH, van Es JH, Clevers H |
Title |
Caught up in a Wnt storm: Wnt signaling in cancer. |
Journal |
|
Reference |
|
Authors |
Behrens J. |
Title |
The role of the Wnt signalling pathway in colorectal tumorigenesis. |
Journal |
|
Reference |
|
Authors |
Ryan AJ, Susil B, Jobling TW, Oehler MK. |
Title |
Endometrial cancer. |
Journal |
|
Reference |
|
Authors |
Villanueva A, Newell P, Chiang DY, Friedman SL, Llovet JM. |
Title |
Genomics and signaling pathways in hepatocellular carcinoma. |
Journal |
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LinkDB |
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