Homo sapiens (human): 6934 Help Entry 6934              CDS       T01001                                  Symbol TCF7L2, TCF-4, TCF4 Name (RefSeq) transcription factor 7 like 2   KO K04491   transcription factor 7-like 2 Organism hsa  Homo sapiens (human) Pathway hsa04310   Wnt signaling pathway hsa04390   Hippo signaling pathway hsa04520   Adherens junction hsa04916   Melanogenesis hsa04934   Cushing syndrome hsa04936   Alcoholic liver disease hsa05132   Salmonella infection hsa05165   Human papillomavirus infection hsa05167   Kaposi sarcoma-associated herpesvirus infection hsa05200   Pathways in cancer hsa05210   Colorectal cancer hsa05213   Endometrial cancer hsa05215   Prostate cancer hsa05216   Thyroid cancer hsa05217   Basal cell carcinoma hsa05221   Acute myeloid leukemia hsa05224   Breast cancer hsa05225   Hepatocellular carcinoma hsa05226   Gastric cancer hsa05412   Arrhythmogenic right ventricular cardiomyopathy Network   Element N00056   Wnt signaling pathway N00057   Mutation-inactivated APC to Wnt signaling pathway N00058   Mutation-activated CTNNB1 to Wnt signaling pathway N00059   FZD7-overexpression to Wnt signaling pathway N00060   LRP6-overexpression to Wnt signaling pathway N00061   CDH1-reduced expression to beta-catenin signaling pathway N00175   KSHV LANA to Wnt signaling pathway N00242   Mutation-inactivated AXIN to Wnt signaling pathway N00257   Loss of CDH1 to beta-catenin signaling pathway N00258   Mutation-inactivated CDH1 to beta-catenin signaling pathway N01124   Salmonella AvrA to beta-catenin signaling pathway Disease H00409   Type 2 diabetes mellitus Brite KEGG Orthology (KO) [BR:hsa00001]  09130 Environmental Information Processing   09132 Signal transduction    04310 Wnt signaling pathway     6934 (TCF7L2)    04390 Hippo signaling pathway     6934 (TCF7L2)  09140 Cellular Processes   09144 Cellular community - eukaryotes    04520 Adherens junction     6934 (TCF7L2)  09150 Organismal Systems   09152 Endocrine system    04916 Melanogenesis     6934 (TCF7L2)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     6934 (TCF7L2)   09162 Cancer: specific types    05210 Colorectal cancer     6934 (TCF7L2)    05225 Hepatocellular carcinoma     6934 (TCF7L2)    05226 Gastric cancer     6934 (TCF7L2)    05216 Thyroid cancer     6934 (TCF7L2)    05221 Acute myeloid leukemia     6934 (TCF7L2)    05217 Basal cell carcinoma     6934 (TCF7L2)    05215 Prostate cancer     6934 (TCF7L2)    05213 Endometrial cancer     6934 (TCF7L2)    05224 Breast cancer     6934 (TCF7L2)   09172 Infectious disease: viral    05167 Kaposi sarcoma-associated herpesvirus infection     6934 (TCF7L2)    05165 Human papillomavirus infection     6934 (TCF7L2)   09171 Infectious disease: bacterial    05132 Salmonella infection     6934 (TCF7L2)   09166 Cardiovascular disease    05412 Arrhythmogenic right ventricular cardiomyopathy     6934 (TCF7L2)   09167 Endocrine and metabolic disease    04936 Alcoholic liver disease     6934 (TCF7L2)    04934 Cushing syndrome     6934 (TCF7L2)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    03000 Transcription factors [BR:hsa03000]     6934 (TCF7L2) Transcription factors [BR:hsa03000]  Eukaryotic type   beta-Scaffold factors with minor groove contacts    HMG TCF-1     6934 (TCF7L2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  CTNNB1_binding HMG_box HMG_box_2 Motif Other DBs NCBI-GeneID:  6934 NCBI-ProteinID:  NP_001139746 OMIM:  602228 HGNC:  11641 Ensembl:  ENSG00000148737 UniProt:  Q9NQB0 Structure PDB LinkDB All DBs Position 10:112950247..113167678 Genome browser AA seq 602 aa AA seqDB search MPQLNGGGGDDLGANDELISFKDEGEQEEKSSENSSAERDLADVKSSLVNESETNQNSSS DSEAERRPPPRSESFRDKSRESLEEAAKRQDGGLFKGPPYPGYPFIMIPDLTSPYLPNGS LSPTARTLHFQSGSTHYSAYKTIEHQIAVQYLQMKWPLLDVQAGSLQSRQALKDARSPSP AHIVSNKVPVVQHPHHVHPLTPLITYSNEHFTPGNPPPHLPADVDPKTGIPRPPHPPDIS PYYPLSPGTVGQIPHPLGWLVPQQGQPVYPITTGGFRHPYPTALTVNASMSRFPPHMVPP HHTLHTTGIPHPAIVTPTVKQESSQSDVGSLHSSKHQDSKKEEEKKKPHIKKPLNAFMLY MKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSAR DNYGKKKKRKRDKQPGETNDANTPKKCRALFGLDRQTLWCKPCRRKKKCVRYIQGEGSCL SPPSSDGSLLDSPPPSPNLLGSPPRDAKSQTEQTQPLSLSLKPDPLAHLSMMPPPPALLL AEATHKASALCPNGALDLPPAALQPAAPSSSIAQPSTSSLHSHSSLAGTQPQPLSLVTKS LE NT seq 1809 nt NT seq  +upstreamnt  +downstreamnt atgccgcagctgaacggcggtggaggggatgacctaggcgccaacgacgaactgatttcc ttcaaagacgagggcgaacaggaggagaagagctccgaaaactcctcggcagagagggat ttagctgatgtcaaatcgtctctagtcaatgaatcagaaacgaatcaaaacagctcctcc gattccgaggcggaaagacggcctccgcctcgctccgaaagtttccgagacaaatcccgg gaaagtttggaagaagcggccaagaggcaagatggagggctctttaaggggccaccgtat cccggctaccccttcatcatgatccccgacctgacgagcccctacctccccaacggatcg ctctcgcccaccgcccgaaccctccattttcagtccggcagcacacattactctgcgtac aaaacgattgaacaccagattgcagttcagtatctccagatgaaatggccactgcttgat gtccaggcagggagcctccagagtagacaagccctcaaggatgcccggtccccatcaccg gcacacattgtctctaacaaagtgccagtggtgcagcaccctcaccatgtccaccccctc acgcctcttatcacgtacagcaatgaacacttcacgccgggaaacccacctccacactta ccagccgacgtagaccccaaaacaggaatcccacggcctccgcaccctccagatatatcc ccgtattacccactatcgcctggcaccgtaggacaaatcccccatccgctaggatggtta gtaccacagcaaggtcaaccagtgtacccaatcacgacaggaggattcagacacccctac cccacagctctgaccgtcaatgcttccatgtccaggttccctccccatatggtcccacca catcatacgctacacacgacgggcattccgcatccggccatagtcacaccaacagtcaaa caggaatcgtcccagagtgatgtcggctcactccatagttcaaagcatcaggactccaaa aaggaagaagaaaagaagaagccccacataaagaaacctcttaatgcattcatgttgtat atgaaggaaatgagagcaaaggtcgtagctgagtgcacgttgaaagaaagcgcggccatc aaccagatccttgggcggaggtggcatgcactgtccagagaagagcaagcgaaatactac gagctggcccggaaggagcgacagcttcatatgcaactgtaccccggctggtccgcgcgg gataactatggaaagaagaagaagaggaaaagggacaagcagccgggagagaccaatgat gcaaatactccaaagaagtgtcgggcactgttcgggcttgaccgacagactttatggtgc aaaccgtgcaggagaaaaaaaaagtgcgttcgctacatacaaggtgaaggcagctgcctc agcccaccctcttcagatggaagcttactagattcgcctcccccctccccgaacctgcta ggctcccctccccgagacgccaagtcacagactgagcagacccagcctctgtcgctgtcc ctgaagcccgaccccctggcccacctgtccatgatgcctccgccacccgccctcctgctc gctgaggccacccacaaggcctccgccctctgtcccaacggggccctggacctgccccca gccgctttgcagcctgccgccccctcctcatcaattgcacagccgtcgacttcttcctta cattcccacagctccctggccgggacccagccccagccgctgtcgctcgtcaccaagtct ttagaatag

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