Entry |
|
Symbol |
TCF7L2, TCF-4, TCF4
|
Name |
(RefSeq) transcription factor 7 like 2
|
KO |
K04491 | transcription factor 7-like 2 |
|
Organism |
|
Pathway |
hsa05167 | Kaposi sarcoma-associated herpesvirus infection |
hsa05412 | Arrhythmogenic right ventricular cardiomyopathy |
|
Network |
|
Element |
N00057 | Mutation-inactivated APC to Wnt signaling pathway |
N00058 | Mutation-activated CTNNB1 to Wnt signaling pathway |
N00059 | FZD7-overexpression to Wnt signaling pathway |
N00060 | LRP6-overexpression to Wnt signaling pathway |
N00061 | CDH1-reduced expression to beta-catenin signaling pathway |
N00175 | KSHV LANA to Wnt signaling pathway |
N00242 | Mutation-inactivated AXIN to Wnt signaling pathway |
N00257 | Loss of CDH1 to beta-catenin signaling pathway |
N00258 | Mutation-inactivated CDH1 to beta-catenin signaling pathway |
N01124 | Salmonella AvrA to beta-catenin signaling pathway |
|
Disease |
H00409 | Type 2 diabetes mellitus |
|
Brite |
KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
09132 Signal transduction
04310 Wnt signaling pathway
6934 (TCF7L2)
04390 Hippo signaling pathway
6934 (TCF7L2)
09140 Cellular Processes
09144 Cellular community - eukaryotes
04520 Adherens junction
6934 (TCF7L2)
09150 Organismal Systems
09152 Endocrine system
04916 Melanogenesis
6934 (TCF7L2)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
6934 (TCF7L2)
09162 Cancer: specific types
05210 Colorectal cancer
6934 (TCF7L2)
05225 Hepatocellular carcinoma
6934 (TCF7L2)
05226 Gastric cancer
6934 (TCF7L2)
05216 Thyroid cancer
6934 (TCF7L2)
05221 Acute myeloid leukemia
6934 (TCF7L2)
05217 Basal cell carcinoma
6934 (TCF7L2)
05215 Prostate cancer
6934 (TCF7L2)
05213 Endometrial cancer
6934 (TCF7L2)
05224 Breast cancer
6934 (TCF7L2)
09172 Infectious disease: viral
05167 Kaposi sarcoma-associated herpesvirus infection
6934 (TCF7L2)
05165 Human papillomavirus infection
6934 (TCF7L2)
09171 Infectious disease: bacterial
05132 Salmonella infection
6934 (TCF7L2)
09166 Cardiovascular disease
05412 Arrhythmogenic right ventricular cardiomyopathy
6934 (TCF7L2)
09167 Endocrine and metabolic disease
04936 Alcoholic liver disease
6934 (TCF7L2)
04934 Cushing syndrome
6934 (TCF7L2)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03000 Transcription factors [BR:hsa03000]
6934 (TCF7L2)
Transcription factors [BR:hsa03000]
Eukaryotic type
beta-Scaffold factors with minor groove contacts
HMG TCF-1
6934 (TCF7L2)
|
SSDB |
|
Motif |
|
Other DBs |
|
Structure |
|
LinkDB |
|
Position |
10:112950247..113167678
|
AA seq |
602 aa
MPQLNGGGGDDLGANDELISFKDEGEQEEKSSENSSAERDLADVKSSLVNESETNQNSSS
DSEAERRPPPRSESFRDKSRESLEEAAKRQDGGLFKGPPYPGYPFIMIPDLTSPYLPNGS
LSPTARTLHFQSGSTHYSAYKTIEHQIAVQYLQMKWPLLDVQAGSLQSRQALKDARSPSP
AHIVSNKVPVVQHPHHVHPLTPLITYSNEHFTPGNPPPHLPADVDPKTGIPRPPHPPDIS
PYYPLSPGTVGQIPHPLGWLVPQQGQPVYPITTGGFRHPYPTALTVNASMSRFPPHMVPP
HHTLHTTGIPHPAIVTPTVKQESSQSDVGSLHSSKHQDSKKEEEKKKPHIKKPLNAFMLY
MKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSAR
DNYGKKKKRKRDKQPGETNDANTPKKCRALFGLDRQTLWCKPCRRKKKCVRYIQGEGSCL
SPPSSDGSLLDSPPPSPNLLGSPPRDAKSQTEQTQPLSLSLKPDPLAHLSMMPPPPALLL
AEATHKASALCPNGALDLPPAALQPAAPSSSIAQPSTSSLHSHSSLAGTQPQPLSLVTKS
LE |
NT seq |
1809 nt +upstreamnt +downstreamnt
atgccgcagctgaacggcggtggaggggatgacctaggcgccaacgacgaactgatttcc
ttcaaagacgagggcgaacaggaggagaagagctccgaaaactcctcggcagagagggat
ttagctgatgtcaaatcgtctctagtcaatgaatcagaaacgaatcaaaacagctcctcc
gattccgaggcggaaagacggcctccgcctcgctccgaaagtttccgagacaaatcccgg
gaaagtttggaagaagcggccaagaggcaagatggagggctctttaaggggccaccgtat
cccggctaccccttcatcatgatccccgacctgacgagcccctacctccccaacggatcg
ctctcgcccaccgcccgaaccctccattttcagtccggcagcacacattactctgcgtac
aaaacgattgaacaccagattgcagttcagtatctccagatgaaatggccactgcttgat
gtccaggcagggagcctccagagtagacaagccctcaaggatgcccggtccccatcaccg
gcacacattgtctctaacaaagtgccagtggtgcagcaccctcaccatgtccaccccctc
acgcctcttatcacgtacagcaatgaacacttcacgccgggaaacccacctccacactta
ccagccgacgtagaccccaaaacaggaatcccacggcctccgcaccctccagatatatcc
ccgtattacccactatcgcctggcaccgtaggacaaatcccccatccgctaggatggtta
gtaccacagcaaggtcaaccagtgtacccaatcacgacaggaggattcagacacccctac
cccacagctctgaccgtcaatgcttccatgtccaggttccctccccatatggtcccacca
catcatacgctacacacgacgggcattccgcatccggccatagtcacaccaacagtcaaa
caggaatcgtcccagagtgatgtcggctcactccatagttcaaagcatcaggactccaaa
aaggaagaagaaaagaagaagccccacataaagaaacctcttaatgcattcatgttgtat
atgaaggaaatgagagcaaaggtcgtagctgagtgcacgttgaaagaaagcgcggccatc
aaccagatccttgggcggaggtggcatgcactgtccagagaagagcaagcgaaatactac
gagctggcccggaaggagcgacagcttcatatgcaactgtaccccggctggtccgcgcgg
gataactatggaaagaagaagaagaggaaaagggacaagcagccgggagagaccaatgat
gcaaatactccaaagaagtgtcgggcactgttcgggcttgaccgacagactttatggtgc
aaaccgtgcaggagaaaaaaaaagtgcgttcgctacatacaaggtgaaggcagctgcctc
agcccaccctcttcagatggaagcttactagattcgcctcccccctccccgaacctgcta
ggctcccctccccgagacgccaagtcacagactgagcagacccagcctctgtcgctgtcc
ctgaagcccgaccccctggcccacctgtccatgatgcctccgccacccgccctcctgctc
gctgaggccacccacaaggcctccgccctctgtcccaacggggccctggacctgccccca
gccgctttgcagcctgccgccccctcctcatcaattgcacagccgtcgacttcttcctta
cattcccacagctccctggccgggacccagccccagccgctgtcgctcgtcaccaagtct
ttagaatag |