KEGG T01001: 6934

Homo sapiens (human): 6934

Entry

6934              CDS       T01001

Symbol

TCF7L2, TCF-4, TCF4

Name

(RefSeq) transcription factor 7 like 2

K04491

transcription factor 7-like 2

Organism

hsa Homo sapiens (human)

Pathway

hsa04310

Wnt signaling pathway

hsa04390

Hippo signaling pathway

hsa04520

Adherens junction

hsa04916

Melanogenesis

hsa04934

Cushing syndrome

hsa04936

Alcoholic liver disease

hsa05132

Salmonella infection

hsa05165

Human papillomavirus infection

hsa05167

Kaposi sarcoma-associated herpesvirus infection

hsa05200

Pathways in cancer

hsa05210

Colorectal cancer

hsa05213

Endometrial cancer

hsa05215

Prostate cancer

hsa05216

Thyroid cancer

hsa05217

Basal cell carcinoma

hsa05221

Acute myeloid leukemia

hsa05224

Breast cancer

hsa05225

Hepatocellular carcinoma

hsa05226

Gastric cancer

hsa05412

Arrhythmogenic right ventricular cardiomyopathy

Network

nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06181  Salmonella
nt06215  WNT signaling (cancer)
nt06260  Colorectal cancer
nt06261  Gastric cancer
nt06263  Hepatocellular carcinoma
nt06270  Breast cancer
nt06271  Endometrial cancer
nt06274  Thyroid cancer
nt06505  WNT signaling

Element

N00056

Wnt signaling pathway

N00057

Mutation-inactivated APC to Wnt signaling pathway

N00058

Mutation-activated CTNNB1 to Wnt signaling pathway

N00059

FZD7-overexpression to Wnt signaling pathway

N00060

LRP6-overexpression to Wnt signaling pathway

N00061

CDH1-reduced expression to beta-catenin signaling pathway

N00175

KSHV LANA to Wnt signaling pathway

N00242

Mutation-inactivated AXIN to Wnt signaling pathway

N00257

Loss of CDH1 to beta-catenin signaling pathway

N00258

Mutation-inactivated CDH1 to beta-catenin signaling pathway

N01124

Salmonella AvrA to beta-catenin signaling pathway

Disease

H00409

Type 2 diabetes mellitus

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04310 Wnt signaling pathway
    6934 (TCF7L2)
   04390 Hippo signaling pathway
    6934 (TCF7L2)
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04520 Adherens junction
    6934 (TCF7L2)
09150 Organismal Systems
  09152 Endocrine system
   04916 Melanogenesis
    6934 (TCF7L2)
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    6934 (TCF7L2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    6934 (TCF7L2)
   05225 Hepatocellular carcinoma
    6934 (TCF7L2)
   05226 Gastric cancer
    6934 (TCF7L2)
   05216 Thyroid cancer
    6934 (TCF7L2)
   05221 Acute myeloid leukemia
    6934 (TCF7L2)
   05217 Basal cell carcinoma
    6934 (TCF7L2)
   05215 Prostate cancer
    6934 (TCF7L2)
   05213 Endometrial cancer
    6934 (TCF7L2)
   05224 Breast cancer
    6934 (TCF7L2)
  09172 Infectious disease: viral
   05167 Kaposi sarcoma-associated herpesvirus infection
    6934 (TCF7L2)
   05165 Human papillomavirus infection
    6934 (TCF7L2)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    6934 (TCF7L2)
  09166 Cardiovascular disease
   05412 Arrhythmogenic right ventricular cardiomyopathy
    6934 (TCF7L2)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    6934 (TCF7L2)
   04934 Cushing syndrome
    6934 (TCF7L2)
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    6934 (TCF7L2)
Transcription factors [BR:hsa03000]
Eukaryotic type
  beta-Scaffold factors with minor groove contacts
   HMG TCF-1
    6934 (TCF7L2)

SSDB

Motif

Pfam:

CTNNB1_binding HMG_box HMG_box_2 HMG_WDHD1

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

Structure

LinkDB

Position

10:112950247..113167678

AA seq 602 aa
MPQLNGGGGDDLGANDELISFKDEGEQEEKSSENSSAERDLADVKSSLVNESETNQNSSS
DSEAERRPPPRSESFRDKSRESLEEAAKRQDGGLFKGPPYPGYPFIMIPDLTSPYLPNGS
LSPTARTLHFQSGSTHYSAYKTIEHQIAVQYLQMKWPLLDVQAGSLQSRQALKDARSPSP
AHIVSNKVPVVQHPHHVHPLTPLITYSNEHFTPGNPPPHLPADVDPKTGIPRPPHPPDIS
PYYPLSPGTVGQIPHPLGWLVPQQGQPVYPITTGGFRHPYPTALTVNASMSRFPPHMVPP
HHTLHTTGIPHPAIVTPTVKQESSQSDVGSLHSSKHQDSKKEEEKKKPHIKKPLNAFMLY
MKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSAR
DNYGKKKKRKRDKQPGETNDANTPKKCRALFGLDRQTLWCKPCRRKKKCVRYIQGEGSCL
SPPSSDGSLLDSPPPSPNLLGSPPRDAKSQTEQTQPLSLSLKPDPLAHLSMMPPPPALLL
AEATHKASALCPNGALDLPPAALQPAAPSSSIAQPSTSSLHSHSSLAGTQPQPLSLVTKS
LE

NT seq 1809 nt +upstreamnt +downstreamnt
atgccgcagctgaacggcggtggaggggatgacctaggcgccaacgacgaactgatttcc
ttcaaagacgagggcgaacaggaggagaagagctccgaaaactcctcggcagagagggat
ttagctgatgtcaaatcgtctctagtcaatgaatcagaaacgaatcaaaacagctcctcc
gattccgaggcggaaagacggcctccgcctcgctccgaaagtttccgagacaaatcccgg
gaaagtttggaagaagcggccaagaggcaagatggagggctctttaaggggccaccgtat
cccggctaccccttcatcatgatccccgacctgacgagcccctacctccccaacggatcg
ctctcgcccaccgcccgaaccctccattttcagtccggcagcacacattactctgcgtac
aaaacgattgaacaccagattgcagttcagtatctccagatgaaatggccactgcttgat
gtccaggcagggagcctccagagtagacaagccctcaaggatgcccggtccccatcaccg
gcacacattgtctctaacaaagtgccagtggtgcagcaccctcaccatgtccaccccctc
acgcctcttatcacgtacagcaatgaacacttcacgccgggaaacccacctccacactta
ccagccgacgtagaccccaaaacaggaatcccacggcctccgcaccctccagatatatcc
ccgtattacccactatcgcctggcaccgtaggacaaatcccccatccgctaggatggtta
gtaccacagcaaggtcaaccagtgtacccaatcacgacaggaggattcagacacccctac
cccacagctctgaccgtcaatgcttccatgtccaggttccctccccatatggtcccacca
catcatacgctacacacgacgggcattccgcatccggccatagtcacaccaacagtcaaa
caggaatcgtcccagagtgatgtcggctcactccatagttcaaagcatcaggactccaaa
aaggaagaagaaaagaagaagccccacataaagaaacctcttaatgcattcatgttgtat
atgaaggaaatgagagcaaaggtcgtagctgagtgcacgttgaaagaaagcgcggccatc
aaccagatccttgggcggaggtggcatgcactgtccagagaagagcaagcgaaatactac
gagctggcccggaaggagcgacagcttcatatgcaactgtaccccggctggtccgcgcgg
gataactatggaaagaagaagaagaggaaaagggacaagcagccgggagagaccaatgat
gcaaatactccaaagaagtgtcgggcactgttcgggcttgaccgacagactttatggtgc
aaaccgtgcaggagaaaaaaaaagtgcgttcgctacatacaaggtgaaggcagctgcctc
agcccaccctcttcagatggaagcttactagattcgcctcccccctccccgaacctgcta
ggctcccctccccgagacgccaagtcacagactgagcagacccagcctctgtcgctgtcc
ctgaagcccgaccccctggcccacctgtccatgatgcctccgccacccgccctcctgctc
gctgaggccacccacaaggcctccgccctctgtcccaacggggccctggacctgccccca
gccgctttgcagcctgccgccccctcctcatcaattgcacagccgtcgacttcttcctta
cattcccacagctccctggccgggacccagccccagccgctgtcgctcgtcaccaagtct
ttagaatag

DBGET integrated database retrieval system