KEGG   NETWORK: N00062
Entry
N00062                      Network                                
Name
Hedgehog signaling pathway
Definition
HH -> PTCH // SMO -> (SMO+EVC) -> (SUFU+KIF7) // GLI => (GLI1,PTCH,HHIP)
  Expanded
(6469,3549,50846) -> (5727,8643) // 6608 -> (6608+(2121,132884)) -> (51684+374654) // (2735,2736,2737) => (2735,5727,8643,64399)
Class
nt06501 HH signaling
nt06269 Basal cell carcinoma
nt06217 HH signaling (cancer)
Type
Reference
Pathway
hsa04340  Hedgehog signaling pathway
Gene
6469  SHH; sonic hedgehog
3549  IHH; Indian hedgehog signaling molecule
50846  DHH; desert hedgehog signaling molecule
5727  PTCH1; patched 1
8643  PTCH2; patched 2
6608  SMO; smoothened, frizzled class receptor
2121  EVC; EvC ciliary complex subunit 1
132884  EVC2; EvC ciliary complex subunit 2
51684  SUFU; SUFU negative regulator of hedgehog signaling
374654  KIF7; kinesin family member 7
2735  GLI1; GLI family zinc finger 1
2736  GLI2; GLI family zinc finger 2
2737  GLI3; GLI family zinc finger 3
64399  HHIP; hedgehog interacting protein
Reference
PMID:23719536
  Authors
Briscoe J, Therond PP
  Title
The mechanisms of Hedgehog signalling and its roles in development and disease.
  Journal
Nat Rev Mol Cell Biol 14:416-29 (2013)
DOI:10.1038/nrm3598
Reference
PMID:26077918
  Authors
Alman BA
  Title
The role of hedgehog signalling in skeletal health and disease.
  Journal
Nat Rev Rheumatol 11:552-60 (2015)
DOI:10.1038/nrrheum.2015.84
Reference
PMID:14556242
  Authors
Cohen MM Jr.
  Title
The hedgehog signaling network.
  Journal
Am J Med Genet A 123:5-28 (2003)
DOI:10.1002/ajmg.a.20495
Reference
PMID:23799571
  Authors
Sasai N, Briscoe J
  Title
Primary cilia and graded Sonic Hedgehog signaling.
  Journal
Wiley Interdiscip Rev Dev Biol 1:753-72 (2012)
DOI:10.1002/wdev.43
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