KEGG   NETWORK: N00090
Entry
N00090                      Network                                
Name
p15-Cell cycle G1/S
Definition
(MYC+MAX) -| ZBTB17 => CDKN2B -| (CCND+CDK4/6) -> RB1 // E2F
  Expanded
(4609+4149) -| 7709 => 1030 -| ((595,894,896)+(1019,1021)) -> 5925 // (1869,1870,1871)
Class
nt06267 Small cell lung cancer
nt06230 Cell cycle
nt06160 Human T-cell leukemia virus 1 (HTLV-1)
nt06130 Cell cycle (viruses)
Type
Reference
Pathway
hsa04110  Cell cycle
Gene
4609  MYC; MYC proto-oncogene, bHLH transcription factor
4149  MAX; MYC associated factor X
7709  ZBTB17; zinc finger and BTB domain containing 17
1030  CDKN2B; cyclin dependent kinase inhibitor 2B
595  CCND1; cyclin D1
894  CCND2; cyclin D2
896  CCND3; cyclin D3
1019  CDK4; cyclin dependent kinase 4
1021  CDK6; cyclin dependent kinase 6
5925  RB1; RB transcriptional corepressor 1
1869  E2F1; E2F transcription factor 1
1870  E2F2; E2F transcription factor 2
1871  E2F3; E2F transcription factor 3
Reference
PMID:16064138
  Authors
Adhikary S, Eilers M.
  Title
Transcriptional regulation and transformation by Myc proteins.
  Journal
Nat Rev Mol Cell Biol 6:635-45 (2005)
DOI:10.1038/nrm1703
Reference
PMID:11720740
  Authors
Zajac-Kaye M
  Title
Myc oncogene: a key component in cell cycle regulation and its implication for lung cancer.
  Journal
Lung Cancer 34 Suppl 2:S43-6 (2001)
DOI:10.1016/S0169-5002(01)00343-9
LinkDB

DBGET integrated database retrieval system