| Entry |
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| Name |
ERBB2-overexpression to EGF-Jak-STAT signaling pathway
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| Definition |
EGF -> (ERBB2*+EGFR) -> JAK1 -> STAT1/3 => VEGFA |
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| Expanded |
1950 -> (2064v1+1956) -> 3716 -> (6772,6774) => 7422 |
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| Class |
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| Type |
Variant
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| Pathway |
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| Disease |
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| Gene |
| 1950 | EGF; epidermal growth factor |
| 2064 | ERBB2; erb-b2 receptor tyrosine kinase 2 |
| 1956 | EGFR; epidermal growth factor receptor |
| 3716 | JAK1; Janus kinase 1 |
| 6772 | STAT1; signal transducer and activator of transcription 1 |
| 6774 | STAT3; signal transducer and activator of transcription 3 |
| 7422 | VEGFA; vascular endothelial growth factor A |
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| Variant |
2064v1 (ERBB2*) ERBB2 overexpression
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| Reference |
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| Authors |
DeArmond D, Brattain MG, Jessup JM, Kreisberg J, Malik S, Zhao S, Freeman JW. |
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| Title |
Autocrine-mediated ErbB-2 kinase activation of STAT3 is required for growth factor independence of pancreatic cancer cell lines. |
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| Journal |
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| Reference |
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| Authors |
Wei D, Le X, Zheng L, Wang L, Frey JA, Gao AC, Peng Z, Huang S, Xiong HQ, Abbruzzese JL, Xie K. |
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| Title |
Stat3 activation regulates the expression of vascular endothelial growth factor and human pancreatic cancer angiogenesis and metastasis. |
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| Journal |
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| LinkDB |
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