Homo sapiens (human): 6772
Help
Entry
6772 CDS
T01001
Symbol
STAT1, CANDF7, IMD31A, IMD31B, IMD31C, ISGF-3, STAT91
Name
(RefSeq) signal transducer and activator of transcription 1
KO
K11220
signal transducer and activator of transcription 1
Organism
hsa
Homo sapiens (human)
Pathway
hsa04062
Chemokine signaling pathway
hsa04217
Necroptosis
hsa04380
Osteoclast differentiation
hsa04620
Toll-like receptor signaling pathway
hsa04621
NOD-like receptor signaling pathway
hsa04625
C-type lectin receptor signaling pathway
hsa04630
JAK-STAT signaling pathway
hsa04658
Th1 and Th2 cell differentiation
hsa04659
Th17 cell differentiation
hsa04917
Prolactin signaling pathway
hsa04919
Thyroid hormone signaling pathway
hsa04933
AGE-RAGE signaling pathway in diabetic complications
hsa04935
Growth hormone synthesis, secretion and action
hsa05140
Leishmaniasis
hsa05145
Toxoplasmosis
hsa05152
Tuberculosis
hsa05160
Hepatitis C
hsa05161
Hepatitis B
hsa05162
Measles
hsa05164
Influenza A
hsa05165
Human papillomavirus infection
hsa05167
Kaposi sarcoma-associated herpesvirus infection
hsa05168
Herpes simplex virus 1 infection
hsa05169
Epstein-Barr virus infection
hsa05171
Coronavirus disease - COVID-19
hsa05200
Pathways in cancer
hsa05212
Pancreatic cancer
hsa05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
hsa05321
Inflammatory bowel disease
Network
Element
N00053
Cytokine-Jak-STAT signaling pathway
N00094
EGF-Jak-STAT signaling pathway
N00095
ERBB2-overexpression to EGF-Jak-STAT signaling pathway
N00150
Type I IFN signaling pathway
N00261
KSHV vIRF2 to IFN signaling pathway
N00270
HCV Core to IFN signaling pathway
N00378
HPV E6 to IFN signaling pathway
N00379
HPV E7 to IFN signaling pathway
N00473
EBV BGLF4 to IFN signaling pathway
N00486
EBV LMP1 to Jak-STAT signaling pathway
N00558
HBV pol to IFN signaling pathway
N00575
HSV ICP27 to IFN signaling pathway
N00578
HSV UL41 to IFN signaling pathway
N00694
MV V/P/C to IFN signaling pathway
N00738
IAV NS1 to IFN signaling pathway
N01321
SARS-CoV-2 nsp1/6/13, ORF3a/6/7b and M to IFN signaling pathway
N01554
IL2 family to Jak-STAT signaling pathway
N01556
IL6 family to Jak-STAT signaling pathway
N01558
Type I interferon to Jak-STAT signaling pathway
N01559
Type II interferon to Jak-STAT signaling pathway
N01662
IFN-RIPK1/3 signaling pathway
Disease
H00089
IFN-gamma/IL-12 axis
H01109
Chronic mucocutaneous candidiasis
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04630 JAK-STAT signaling pathway
6772 (STAT1)
09140 Cellular Processes
09143 Cell growth and death
04217 Necroptosis
6772 (STAT1)
09150 Organismal Systems
09151 Immune system
04620 Toll-like receptor signaling pathway
6772 (STAT1)
04621 NOD-like receptor signaling pathway
6772 (STAT1)
04625 C-type lectin receptor signaling pathway
6772 (STAT1)
04658 Th1 and Th2 cell differentiation
6772 (STAT1)
04659 Th17 cell differentiation
6772 (STAT1)
04062 Chemokine signaling pathway
6772 (STAT1)
09152 Endocrine system
04917 Prolactin signaling pathway
6772 (STAT1)
04935 Growth hormone synthesis, secretion and action
6772 (STAT1)
04919 Thyroid hormone signaling pathway
6772 (STAT1)
09158 Development and regeneration
04380 Osteoclast differentiation
6772 (STAT1)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
6772 (STAT1)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
6772 (STAT1)
09162 Cancer: specific types
05212 Pancreatic cancer
6772 (STAT1)
09172 Infectious disease: viral
05161 Hepatitis B
6772 (STAT1)
05160 Hepatitis C
6772 (STAT1)
05171 Coronavirus disease - COVID-19
6772 (STAT1)
05164 Influenza A
6772 (STAT1)
05162 Measles
6772 (STAT1)
05168 Herpes simplex virus 1 infection
6772 (STAT1)
05167 Kaposi sarcoma-associated herpesvirus infection
6772 (STAT1)
05169 Epstein-Barr virus infection
6772 (STAT1)
05165 Human papillomavirus infection
6772 (STAT1)
09171 Infectious disease: bacterial
05152 Tuberculosis
6772 (STAT1)
09174 Infectious disease: parasitic
05145 Toxoplasmosis
6772 (STAT1)
05140 Leishmaniasis
6772 (STAT1)
09163 Immune disease
05321 Inflammatory bowel disease
6772 (STAT1)
09167 Endocrine and metabolic disease
04933 AGE-RAGE signaling pathway in diabetic complications
6772 (STAT1)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03000 Transcription factors [BR:
hsa03000
]
6772 (STAT1)
Transcription factors [BR:
hsa03000
]
Eukaryotic type
beta-Scaffold factors with minor groove contacts
STAT
6772 (STAT1)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
STAT_alpha
STAT_bind
STAT_int
STAT_linker
STAT1_TAZ2bind
SH2
TRPM_tetra
Motif
Other DBs
NCBI-GeneID:
6772
NCBI-ProteinID:
NP_009330
OMIM:
600555
HGNC:
11362
Ensembl:
ENSG00000115415
UniProt:
P42224
Structure
PDB
LinkDB
All DBs
Position
2:complement(190969149..191014171)
Genome browser
AA seq
750 aa
AA seq
DB search
MSQWYELQQLDSKFLEQVHQLYDDSFPMEIRQYLAQWLEKQDWEHAANDVSFATIRFHDL
LSQLDDQYSRFSLENNFLLQHNIRKSKRNLQDNFQEDPIQMSMIIYSCLKEERKILENAQ
RFNQAQSGNIQSTVMLDKQKELDSKVRNVKDKVMCIEHEIKSLEDLQDEYDFKCKTLQNR
EHETNGVAKSDQKQEQLLLKKMYLMLDNKRKEVVHKIIELLNVTELTQNALINDELVEWK
RRQQSACIGGPPNACLDQLQNWFTIVAESLQQVRQQLKKLEELEQKYTYEHDPITKNKQV
LWDRTFSLFQQLIQSSFVVERQPCMPTHPQRPLVLKTGVQFTVKLRLLVKLQELNYNLKV
KVLFDKDVNERNTVKGFRKFNILGTHTKVMNMEESTNGSLAAEFRHLQLKEQKNAGTRTN
EGPLIVTEELHSLSFETQLCQPGLVIDLETTSLPVVVISNVSQLPSGWASILWYNMLVAE
PRNLSFFLTPPCARWAQLSEVLSWQFSSVTKRGLNVDQLNMLGEKLLGPNASPDGLIPWT
RFCKENINDKNFPFWLWIESILELIKKHLLPLWNDGCIMGFISKERERALLKDQQPGTFL
LRFSESSREGAITFTWVERSQNGGEPDFHAVEPYTKKELSAVTFPDIIRNYKVMAAENIP
ENPLKYLYPNIDKDHAFGKYYSRPKEAPEPMELDGPKGTGYIKTELISVSEVHPSRLQTT
DNLLPMSPEEFDEVSRIVGSVEFDSMMNTV
NT seq
2253 nt
NT seq
+upstream
nt +downstream
nt
atgtctcagtggtacgaacttcagcagcttgactcaaaattcctggagcaggttcaccag
ctttatgatgacagttttcccatggaaatcagacagtacctggcacagtggttagaaaag
caagactgggagcacgctgccaatgatgtttcatttgccaccatccgttttcatgacctc
ctgtcacagctggatgatcaatatagtcgcttttctttggagaataacttcttgctacag
cataacataaggaaaagcaagcgtaatcttcaggataattttcaggaagacccaatccag
atgtctatgatcatttacagctgtctgaaggaagaaaggaaaattctggaaaacgcccag
agatttaatcaggctcagtcggggaatattcagagcacagtgatgttagacaaacagaaa
gagcttgacagtaaagtcagaaatgtgaaggacaaggttatgtgtatagagcatgaaatc
aagagcctggaagatttacaagatgaatatgacttcaaatgcaaaaccttgcagaacaga
gaacacgagaccaatggtgtggcaaagagtgatcagaaacaagaacagctgttactcaag
aagatgtatttaatgcttgacaataagagaaaggaagtagttcacaaaataatagagttg
ctgaatgtcactgaacttacccagaatgccctgattaatgatgaactagtggagtggaag
cggagacagcagagcgcctgtattggggggccgcccaatgcttgcttggatcagctgcag
aactggttcactatagttgcggagagtctgcagcaagttcggcagcagcttaaaaagttg
gaggaattggaacagaaatacacctacgaacatgaccctatcacaaaaaacaaacaagtg
ttatgggaccgcaccttcagtcttttccagcagctcattcagagctcgtttgtggtggaa
agacagccctgcatgccaacgcaccctcagaggccgctggtcttgaagacaggggtccag
ttcactgtgaagttgagactgttggtgaaattgcaagagctgaattataatttgaaagtc
aaagtcttatttgataaagatgtgaatgagagaaatacagtaaaaggatttaggaagttc
aacattttgggcacgcacacaaaagtgatgaacatggaggagtccaccaatggcagtctg
gcggctgaatttcggcacctgcaattgaaagaacagaaaaatgctggcaccagaacgaat
gagggtcctctcatcgttactgaagagcttcactcccttagttttgaaacccaattgtgc
cagcctggtttggtaattgacctcgagacgacctctctgcccgttgtggtgatctccaac
gtcagccagctcccgagcggttgggcctccatcctttggtacaacatgctggtggcggaa
cccaggaatctgtccttcttcctgactccaccatgtgcacgatgggctcagctttcagaa
gtgctgagttggcagttttcttctgtcaccaaaagaggtctcaatgtggaccagctgaac
atgttgggagagaagcttcttggtcctaacgccagccccgatggtctcattccgtggacg
aggttttgtaaggaaaatataaatgataaaaattttcccttctggctttggattgaaagc
atcctagaactcattaaaaaacacctgctccctctctggaatgatgggtgcatcatgggc
ttcatcagcaaggagcgagagcgtgccctgttgaaggaccagcagccggggaccttcctg
ctgcggttcagtgagagctcccgggaaggggccatcacattcacatgggtggagcggtcc
cagaacggaggcgaacctgacttccatgcggttgaaccctacacgaagaaagaactttct
gctgttactttccctgacatcattcgcaattacaaagtcatggctgctgagaatattcct
gagaatcccctgaagtatctgtatccaaatattgacaaagaccatgcctttggaaagtat
tactccaggccaaaggaagcaccagagccaatggaacttgatggccctaaaggaactgga
tatatcaagactgagttgatttctgtgtctgaagttcacccttctagacttcagaccaca
gacaacctgctccccatgtctcctgaggagtttgacgaggtgtctcggatagtgggctct
gtagaattcgacagtatgatgaacacagtatag
DBGET
integrated database retrieval system
