KEGG   NETWORK: N00145
Entry
N00145                      Network                                
Name
Extrinsic apoptotic pathway
Definition
TNF -> TNFRSF1A -> (RIPK1+TRADD+TRAF2/5) -> FADD -> CASP8 -> (CASP3,CASP7)
  Expanded
7124 -> 7132 -> (8737+8717+(7186,7188)) -> 8772 -> 841 -> (836,840)
Class
nt06516 TNF signaling
nt06524 Apoptosis
nt06263 Hepatocellular carcinoma
nt06231 Apoptosis (cancer)
nt06461 Huntington disease
nt06163 Hepatitis C virus (HCV)
nt06168 Herpes simplex virus 1 (HSV-1)
nt06166 Human papillomavirus (HPV)
Type
Reference
Pathway
hsa04210  Apoptosis
hsa04668  TNF signaling pathway
Gene
7124  TNF; tumor necrosis factor
7132  TNFRSF1A; TNF receptor superfamily member 1A
8737  RIPK1; receptor interacting serine/threonine kinase 1
8717  TRADD; TNFRSF1A associated via death domain
7186  TRAF2; TNF receptor associated factor 2
7188  TRAF5; TNF receptor associated factor 5
8772  FADD; Fas associated via death domain
841  CASP8; caspase 8
836  CASP3; caspase 3
840  CASP7; caspase 7
Reference
PMID:21697901
  Authors
Vucic D, Dixit VM, Wertz IE
  Title
Ubiquitylation in apoptosis: a post-translational modification at the edge of life and death.
  Journal
Nat Rev Mol Cell Biol 12:439-52 (2011)
DOI:10.1038/nrm3143
Reference
PMID:24685981
  Authors
Beesoo R, Neergheen-Bhujun V, Bhagooli R, Bahorun T
  Title
Apoptosis inducing lead compounds isolated from marine organisms of potential relevance in cancer treatment.
  Journal
Mutat Res 768:84-97 (2014)
DOI:10.1016/j.mrfmmm.2014.03.005
Reference
PMID:15218528
  Authors
MacFarlane M, Williams AC
  Title
Apoptosis and disease: a life or death decision.
  Journal
EMBO Rep 5:674-8 (2004)
DOI:10.1038/sj.embor.7400191
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