KEGG   Homo sapiens (human): 7132
Entry
7132              CDS       T01001                                 
Symbol
TNFRSF1A, CD120a, FPF, TBP1, TNF-R, TNF-R-I, TNF-R55, TNFAR, TNFR1, TNFR55, TNFR60, p55, p55-R, p60
Name
(RefSeq) TNF receptor superfamily member 1A
  KO
K03158  tumor necrosis factor receptor superfamily member 1A
Organism
hsa  Homo sapiens (human)
Pathway
hsa04010  MAPK signaling pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04061  Viral protein interaction with cytokine and cytokine receptor
hsa04064  NF-kappa B signaling pathway
hsa04071  Sphingolipid signaling pathway
hsa04150  mTOR signaling pathway
hsa04210  Apoptosis
hsa04215  Apoptosis - multiple species
hsa04217  Necroptosis
hsa04380  Osteoclast differentiation
hsa04668  TNF signaling pathway
hsa04920  Adipocytokine signaling pathway
hsa04931  Insulin resistance
hsa04932  Non-alcoholic fatty liver disease
hsa04936  Alcoholic liver disease
hsa05010  Alzheimer disease
hsa05014  Amyotrophic lateral sclerosis
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05130  Pathogenic Escherichia coli infection
hsa05131  Shigellosis
hsa05132  Salmonella infection
hsa05142  Chagas disease
hsa05145  Toxoplasmosis
hsa05152  Tuberculosis
hsa05160  Hepatitis C
hsa05163  Human cytomegalovirus infection
hsa05164  Influenza A
hsa05165  Human papillomavirus infection
hsa05166  Human T-cell leukemia virus 1 infection
hsa05167  Kaposi sarcoma-associated herpesvirus infection
hsa05168  Herpes simplex virus 1 infection
hsa05170  Human immunodeficiency virus 1 infection
hsa05171  Coronavirus disease - COVID-19
hsa05417  Lipid and atherosclerosis
hsa05418  Fluid shear stress and atherosclerosis
Network
nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06161  Human immunodeficiency virus 1 (HIV-1)
nt06163  Hepatitis C virus (HCV)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165  Epstein-Barr virus (EBV)
nt06166  Human papillomavirus (HPV)
nt06167  Human cytomegalovirus (HCMV)
nt06168  Herpes simplex virus 1 (HSV-1)
nt06180  Pathogenic Escherichia coli
nt06181  Salmonella
nt06182  Shigella
nt06223  TNF signaling (cancer)
nt06231  Apoptosis (cancer)
nt06263  Hepatocellular carcinoma
nt06461  Huntington disease
nt06516  TNF signaling
nt06524  Apoptosis
nt06527  Necroptosis
  Element
N00145  Extrinsic apoptotic pathway
N00151  TNF-NFKB signaling pathway
N00350  HPV E6 to extrinsic apoptotic pathway
N00441  HIV gp120 to TNF-NFKB signaling pathway
N00444  TNF-p38 signaling pathway
N00446  TNF-JNK signaling pathway
N01114  Salmonella SseK3 to TNF-NFKB signaling pathway
N01545  Regulation of TNF-NFKB signaling pathway, LUBAC-mediated linear ubiquitination
N01621  TNF-RIPK1/3 signaling pathway
Disease
H00912  Tumor necrosis factor receptor-associated periodic syndrome
H01490  Multiple sclerosis
Drug target
Tasonermin: D08562
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04064 NF-kappa B signaling pathway
    7132 (TNFRSF1A)
   04668 TNF signaling pathway
    7132 (TNFRSF1A)
   04071 Sphingolipid signaling pathway
    7132 (TNFRSF1A)
   04150 mTOR signaling pathway
    7132 (TNFRSF1A)
  09133 Signaling molecules and interaction
   04061 Viral protein interaction with cytokine and cytokine receptor
    7132 (TNFRSF1A)
 09140 Cellular Processes
  09143 Cell growth and death
   04215 Apoptosis - multiple species
    7132 (TNFRSF1A)
 09150 Organismal Systems
  09158 Development and regeneration
   04380 Osteoclast differentiation
    7132 (TNFRSF1A)
 09160 Human Diseases
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    7132 (TNFRSF1A)
   05170 Human immunodeficiency virus 1 infection
    7132 (TNFRSF1A)
   05160 Hepatitis C
    7132 (TNFRSF1A)
   05171 Coronavirus disease - COVID-19
    7132 (TNFRSF1A)
   05164 Influenza A
    7132 (TNFRSF1A)
   05163 Human cytomegalovirus infection
    7132 (TNFRSF1A)
   05167 Kaposi sarcoma-associated herpesvirus infection
    7132 (TNFRSF1A)
   05165 Human papillomavirus infection
    7132 (TNFRSF1A)
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    7132 (TNFRSF1A)
   05131 Shigellosis
    7132 (TNFRSF1A)
   05152 Tuberculosis
    7132 (TNFRSF1A)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    7132 (TNFRSF1A)
   05142 Chagas disease
    7132 (TNFRSF1A)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    7132 (TNFRSF1A)
   05014 Amyotrophic lateral sclerosis
    7132 (TNFRSF1A)
   05022 Pathways of neurodegeneration - multiple diseases
    7132 (TNFRSF1A)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    7132 (TNFRSF1A)
   05418 Fluid shear stress and atherosclerosis
    7132 (TNFRSF1A)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    7132 (TNFRSF1A)
   04932 Non-alcoholic fatty liver disease
    7132 (TNFRSF1A)
   04931 Insulin resistance
    7132 (TNFRSF1A)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04050 Cytokine receptors [BR:hsa04050]
    7132 (TNFRSF1A)
   04090 CD molecules [BR:hsa04090]
    7132 (TNFRSF1A)
Cytokine receptors [BR:hsa04050]
 Tumor necrosis factor receptors
  TNF receptor superfamily
   7132 (TNFRSF1A)
CD molecules [BR:hsa04090]
 Proteins
  7132 (TNFRSF1A)
SSDB
Motif
Pfam: TNFR_c6 Death
Other DBs
NCBI-GeneID: 7132
NCBI-ProteinID: NP_001056
OMIM: 191190
HGNC: 11916
Ensembl: ENSG00000067182
UniProt: P19438
Structure
LinkDB
Position
12:complement(6328771..6342076)
AA seq 455 aa
MGLSTVPDLLLPLVLLELLVGIYPSGVIGLVPHLGDREKRDSVCPQGKYIHPQNNSICCT
KCHKGTYLYNDCPGPGQDTDCRECESGSFTASENHLRHCLSCSKCRKEMGQVEISSCTVD
RDTVCGCRKNQYRHYWSENLFQCFNCSLCLNGTVHLSCQEKQNTVCTCHAGFFLRENECV
SCSNCKKSLECTKLCLPQIENVKGTEDSGTTVLLPLVIFFGLCLLSLLFIGLMYRYQRWK
SKLYSIVCGKSTPEKEGELEGTTTKPLAPNPSFSPTPGFTPTLGFSPVPSSTFTSSSTYT
PGDCPNFAAPRREVAPPYQGADPILATALASDPIPNPLQKWEDSAHKPQSLDTDDPATLY
AVVENVPPLRWKEFVRRLGLSDHEIDRLELQNGRCLREAQYSMLATWRRRTPRREATLEL
LGRVLRDMDLLGCLEDIEEALCGPAALPPAPSLLR
NT seq 1368 nt   +upstreamnt  +downstreamnt
atgggcctctccaccgtgcctgacctgctgctgccactggtgctcctggagctgttggtg
ggaatatacccctcaggggttattggactggtccctcacctaggggacagggagaagaga
gatagtgtgtgtccccaaggaaaatatatccaccctcaaaataattcgatttgctgtacc
aagtgccacaaaggaacctacttgtacaatgactgtccaggcccggggcaggatacggac
tgcagggagtgtgagagcggctccttcaccgcttcagaaaaccacctcagacactgcctc
agctgctccaaatgccgaaaggaaatgggtcaggtggagatctcttcttgcacagtggac
cgggacaccgtgtgtggctgcaggaagaaccagtaccggcattattggagtgaaaacctt
ttccagtgcttcaattgcagcctctgcctcaatgggaccgtgcacctctcctgccaggag
aaacagaacaccgtgtgcacctgccatgcaggtttctttctaagagaaaacgagtgtgtc
tcctgtagtaactgtaagaaaagcctggagtgcacgaagttgtgcctaccccagattgag
aatgttaagggcactgaggactcaggcaccacagtgctgttgcccctggtcattttcttt
ggtctttgccttttatccctcctcttcattggtttaatgtatcgctaccaacggtggaag
tccaagctctactccattgtttgtgggaaatcgacacctgaaaaagagggggagcttgaa
ggaactactactaagcccctggccccaaacccaagcttcagtcccactccaggcttcacc
cccaccctgggcttcagtcccgtgcccagttccaccttcacctccagctccacctatacc
cccggtgactgtcccaactttgcggctccccgcagagaggtggcaccaccctatcagggg
gctgaccccatccttgcgacagccctcgcctccgaccccatccccaacccccttcagaag
tgggaggacagcgcccacaagccacagagcctagacactgatgaccccgcgacgctgtac
gccgtggtggagaacgtgcccccgttgcgctggaaggaattcgtgcggcgcctagggctg
agcgaccacgagatcgatcggctggagctgcagaacgggcgctgcctgcgcgaggcgcaa
tacagcatgctggcgacctggaggcggcgcacgccgcggcgcgaggccacgctggagctg
ctgggacgcgtgctccgcgacatggacctgctgggctgcctggaggacatcgaggaggcg
ctttgcggccccgccgccctcccgcccgcgcccagtcttctcagatga

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