Entry |
|
Name |
KSHV K1 to PI3K signaling pathway
|
Definition |
K1 -> PI3K -> PIP3 -> AKT -> MTOR |
Expanded |
K21669 -> (5290,5291,5293) -> C05981 -> (207,208,10000) -> 2475 |
Class |
nt06214 PI3K signaling
nt06114 PI3K signaling (viruses)
nt06164 Kaposi sarcoma-associated herpesvirus (KSHV)
|
Type |
Pathogen
|
Pathway |
hsa05167 | Kaposi sarcoma-associated herpesvirus infection |
|
Disease |
|
Gene |
5290 | PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha |
5291 | PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta |
5293 | PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta |
207 | AKT1; AKT serine/threonine kinase 1 |
208 | AKT2; AKT serine/threonine kinase 2 |
10000 | AKT3; AKT serine/threonine kinase 3 |
2475 | MTOR; mechanistic target of rapamycin |
|
Perturbant |
K21669 (K1) | K1; KSHV protein K1 |
|
Metabolite |
C05981 | Phosphatidylinositol-3,4,5-trisphosphate |
|
Reference |
|
Authors |
Sousa-Squiavinato AC, Silvestre RN, Elgui De Oliveira D |
Title |
Biology and oncogenicity of the Kaposi sarcoma herpesvirus K1 protein. |
Journal |
|
Reference |
|
Authors |
Abere B, Schulz TF |
Title |
KSHV non-structural membrane proteins involved in the activation of intracellular signaling pathways and the pathogenesis of Kaposi's sarcoma. |
Journal |
|
Reference |
|
Authors |
Wang L, Dittmer DP, Tomlinson CC, Fakhari FD, Damania B |
Title |
Immortalization of primary endothelial cells by the K1 protein of Kaposi's sarcoma-associated herpesvirus. |
Journal |
|
LinkDB |
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