| Entry |
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| Name |
KSHV K1 to PI3K signaling pathway
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| Definition |
K1 -> PI3K -> PIP3 -> AKT -> MTOR |
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| Expanded |
K21669 -> (5290,5291,5293) -> C05981 -> (207,208,10000) -> 2475 |
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| Class |
nt06214 PI3K signaling
nt06114 PI3K signaling (viruses)
nt06164 Kaposi sarcoma-associated herpesvirus (KSHV)
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| Type |
Pathogen
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| Pathway |
| hsa05167 | Kaposi sarcoma-associated herpesvirus infection |
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| Disease |
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| Gene |
| 5290 | PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha |
| 5291 | PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta |
| 5293 | PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta |
| 207 | AKT1; AKT serine/threonine kinase 1 |
| 208 | AKT2; AKT serine/threonine kinase 2 |
| 10000 | AKT3; AKT serine/threonine kinase 3 |
| 2475 | MTOR; mechanistic target of rapamycin |
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| Perturbant |
| K21669 (K1) | K1; KSHV protein K1 |
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| Metabolite |
| C05981 | Phosphatidylinositol-3,4,5-trisphosphate |
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| Reference |
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| Authors |
Sousa-Squiavinato AC, Silvestre RN, Elgui De Oliveira D |
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| Title |
Biology and oncogenicity of the Kaposi sarcoma herpesvirus K1 protein. |
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| Journal |
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| Reference |
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| Authors |
Abere B, Schulz TF |
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| Title |
KSHV non-structural membrane proteins involved in the activation of intracellular signaling pathways and the pathogenesis of Kaposi's sarcoma. |
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| Journal |
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| Reference |
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| Authors |
Wang L, Dittmer DP, Tomlinson CC, Fakhari FD, Damania B |
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| Title |
Immortalization of primary endothelial cells by the K1 protein of Kaposi's sarcoma-associated herpesvirus. |
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| Journal |
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| LinkDB |
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