KEGG   NETWORK: N00180
Entry
N00180                      Network                                

Name
KSHV K1 to PLCG-calcineurin signaling pathway
Definition
K1 -> PLCG2 -> IP3 -> Ca2+ -> CALM -- CN -> NFAT
  Expanded
K21669 -> 5336 -> C01245 -> C00076 -> (801,805,808) -- (5530,5532,5533,5534,5535) -> (4772,4773,4775,4776)
Class
nt06220 Calcium signaling
nt06120 Calcium signaling (viruses and bacteria)
nt06164 Kaposi sarcoma-associated herpesvirus (KSHV)
Type
Pathogen
Pathway
hsa05167  Kaposi sarcoma-associated herpesvirus infection
Disease
H00041  Kaposi sarcoma
Gene
5336  PLCG2; phospholipase C gamma 2
801  CALM1; calmodulin 1
805  CALM2; calmodulin 2
808  CALM3; calmodulin 3
5530  PPP3CA; protein phosphatase 3 catalytic subunit alpha
5532  PPP3CB; protein phosphatase 3 catalytic subunit beta
5533  PPP3CC; protein phosphatase 3 catalytic subunit gamma
5534  PPP3R1; protein phosphatase 3 regulatory subunit B, alpha
5535  PPP3R2; protein phosphatase 3 regulatory subunit B, beta
4772  NFATC1; nuclear factor of activated T-cells 1
4773  NFATC2; nuclear factor of activated T-cells 2
4775  NFATC3; nuclear factor of activated T-cells 3
4776  NFATC4; nuclear factor of activated T-cells 4
Perturbant
K21669 (K1)  K1; KSHV protein K1
Metabolite
C01245  D-myo-Inositol 1,4,5-trisphosphate
C00076  Calcium cation
Reference
  Authors
Sousa-Squiavinato AC, Silvestre RN, Elgui De Oliveira D
  Title
Biology and oncogenicity of the Kaposi sarcoma herpesvirus K1 protein.
  Journal
Rev Med Virol 25:273-85 (2015)
DOI:10.1002/rmv.1843
Reference
  Authors
Abere B, Schulz TF
  Title
KSHV non-structural membrane proteins involved in the activation of intracellular signaling pathways and the pathogenesis of Kaposi's sarcoma.
  Journal
Curr Opin Virol 20:11-19 (2016)
DOI:10.1016/j.coviro.2016.07.008
Reference
  Authors
Wang L, Dittmer DP, Tomlinson CC, Fakhari FD, Damania B
  Title
Immortalization of primary endothelial cells by the K1 protein of Kaposi's sarcoma-associated herpesvirus.
  Journal
Cancer Res 66:3658-66 (2006)
DOI:10.1158/0008-5472.CAN-05-3680
Reference
  Authors
Hogan PG, Chen L, Nardone J, Rao A
  Title
Transcriptional regulation by calcium, calcineurin, and NFAT.
  Journal
Genes Dev 17:2205-32 (2003)
DOI:10.1101/gad.1102703
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