KEGG   NETWORK: N00225
Entry
N00225                      Network                                

Name
EBV EBNA2 to RBP-Jk-mediated transcription
Definition
EBNA2 -- SNW1 -> RBPJ => (LMP1,CR2,HES1,FCER2,RUNX3,MYC)
  Expanded
K19457 -- 22938 -> 3516 => (K19459,1380,3280,2208,864,4609)
Class
nt06140 Transcription (viruses)
nt06165 Epstein-Barr virus (EBV)
Type
Pathogen
Pathway
hsa05169  Epstein-Barr virus infection
Disease
H00008  Burkitt lymphoma
H00007  Hodgkin lymphoma
H00054  Nasopharyngeal cancer
Gene
22938  SNW1; SNW domain containing 1
3516  RBPJ; recombination signal binding protein for immunoglobulin kappa J region
1380  CR2; complement C3d receptor 2
3280  HES1; hes family bHLH transcription factor 1
2208  FCER2; Fc fragment of IgE receptor II
864  RUNX3; runt related transcription factor 3
4609  MYC; MYC proto-oncogene, bHLH transcription factor
Perturbant
K19457 (EBNA2)  EBNA2; EBV nuclear antigen 2
K19459 (LMP1)  LMP1; EBV latent membrane protein 1
Reference
  Authors
Saha A, Robertson ES
  Title
Epstein-Barr virus-associated B-cell lymphomas: pathogenesis and clinical outcomes.
  Journal
Clin Cancer Res 17:3056-63 (2011)
DOI:10.1158/1078-0432.CCR-10-2578
Reference
  Authors
Young LS, Rickinson AB.
  Title
Epstein-Barr virus: 40 years on.
  Journal
Nat Rev Cancer 4:757-68 (2004)
DOI:10.1038/nrc1452
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