KEGG   NETWORK: N00228
Entry
N00228                      Network                                
Name
TGFA-overexpression to PLCG-PKC signaling pathway
Definition
TGFA* -> EGFR -> PLCG -> IP3 -> (Ca2+,DAG) -> PKC -> ELK1
  Expanded
7039v1 -> 1956 -> (5335,5336) -> C01245 -> (C00076,C00165) -> (5578,5579,5582) -> 2002
Class
nt06263 Hepatocellular carcinoma
nt06220 Calcium signaling (cancer)
Type
Variant
Pathway
hsa05225  Hepatocellular carcinoma
Disease
H00048  Hepatocellular carcinoma
Gene
7039  TGFA; transforming growth factor alpha
1956  EGFR; epidermal growth factor receptor
5335  PLCG1; phospholipase C gamma 1
5336  PLCG2; phospholipase C gamma 2
5578  PRKCA; protein kinase C alpha
5579  PRKCB; protein kinase C beta
5582  PRKCG; protein kinase C gamma
2002  ELK1; ELK1, ETS transcription factor
Variant
7039v1 (TGFA*)  TGFA overexpression
Metabolite
C01245  D-myo-Inositol 1,4,5-trisphosphate
C00076  Calcium cation
C00165  Diacylglycerol
Reference
PMID:16799620
  Authors
Breuhahn K, Longerich T, Schirmacher P
  Title
Dysregulation of growth factor signaling in human hepatocellular carcinoma.
  Journal
Oncogene 25:3787-800 (2006)
DOI:10.1038/sj.onc.1209556
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