| Entry |
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| Name |
TGFA-EGFR-PI3K signaling pathway
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| Definition |
TGFA -> EGFR -> PI3K -> PIP3 -> AKT -> MTOR |
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| Expanded |
7039 -> 1956 -> (5290,5291,5293) -> C05981 -> (207,208,10000) -> 2475 |
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| Class |
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| Type |
Reference
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| Pathway |
|
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| Gene |
| 7039 | TGFA; transforming growth factor alpha |
| 1956 | EGFR; epidermal growth factor receptor |
| 5290 | PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha |
| 5291 | PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta |
| 5293 | PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta |
| 207 | AKT1; AKT serine/threonine kinase 1 |
| 208 | AKT2; AKT serine/threonine kinase 2 |
| 10000 | AKT3; AKT serine/threonine kinase 3 |
| 2475 | MTOR; mechanistic target of rapamycin |
|
|---|
| Metabolite |
| C05981 | Phosphatidylinositol-3,4,5-trisphosphate |
|
|---|
| Reference |
|
|---|
| Authors |
Janku F, Stewart DJ, Kurzrock R |
|---|
| Title |
Targeted therapy in non-small-cell lung cancer--is it becoming a reality? |
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| Journal |
|
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| Reference |
|
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| Authors |
Mascia F, Denning M, Kopan R, Yuspa SH |
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| Title |
The black box illuminated: signals and signaling. |
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| Journal |
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| Reference |
|
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| Authors |
Marmor MD, Skaria KB, Yarden Y. |
|---|
| Title |
Signal transduction and oncogenesis by ErbB/HER receptors. |
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| Journal |
|
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| Reference |
|
|---|
| Authors |
Scaltriti M, Baselga J. |
|---|
| Title |
The epidermal growth factor receptor pathway: a model for targeted therapy. |
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| Journal |
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| LinkDB |
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