KEGG   NETWORK: N00261
Entry
N00261                      Network                                

Name
KSHV vIRF2 to IFN signaling pathway
Definition
vIRF2 -| (STAT1+STAT2+IRF9)
  Expanded
K21654 -| (6772+6773+10379)
Class
nt06222 IFN signaling
nt06122 IFN signaling (viruses)
nt06164 Kaposi sarcoma-associated herpesvirus (KSHV)
Type
Pathogen
Pathway
hsa05167  Kaposi sarcoma-associated herpesvirus infection
Disease
H00041  Kaposi sarcoma
Gene
6772  STAT1; signal transducer and activator of transcription 1
6773  STAT2; signal transducer and activator of transcription 2
10379  IRF9; interferon regulatory factor 9
Perturbant
K21654 (vIRF2)  vIRF2; KSHV interferon regulatory factor-like protein 2
Reference
  Authors
Schulz TF, Cesarman E
  Title
Kaposi Sarcoma-associated Herpesvirus: mechanisms of oncogenesis.
  Journal
Curr Opin Virol 14:116-28 (2015)
DOI:10.1016/j.coviro.2015.08.016
Reference
  Authors
Mutocheluh M, Hindle L, Areste C, Chanas SA, Butler LM, Lowry K, Shah K, Evans DJ, Blackbourn DJ
  Title
Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor-2 inhibits type 1 interferon signalling by targeting interferon-stimulated gene factor-3.
  Journal
J Gen Virol 92:2394-8 (2011)
DOI:10.1099/vir.0.034322-0
Reference
  Authors
Rezaee SA, Cunningham C, Davison AJ, Blackbourn DJ
  Title
Kaposi's sarcoma-associated herpesvirus immune modulation: an overview.
  Journal
J Gen Virol 87:1781-804 (2006)
DOI:10.1099/vir.0.81919-0
Reference
  Authors
Liang C, Lee JS, Jung JU
  Title
Immune evasion in Kaposi's sarcoma-associated herpes virus associated oncogenesis.
  Journal
Semin Cancer Biol 18:423-36 (2008)
DOI:10.1016/j.semcancer.2008.09.003
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