Entry |
|
Name |
PTH-PTH1R-PKA signaling pathway
|
Definition |
PTH -> PTH1R -> GNAS -> ADCY -> cAMP -> PKA |
Expanded |
5741 -> 5745 -> 2778 -> (107,108,109,196883,111,112,113,114,115) -> C00575 -> (5566+5567+5568) |
Class |
|
Type |
Reference
|
Pathway |
hsa04928 | Parathyroid hormone synthesis, secretion and action |
hsa04961 | Endocrine and other factor-regulated calcium reabsorption |
|
Gene |
5741 | PTH; parathyroid hormone |
5745 | PTH1R; parathyroid hormone 1 receptor |
2778 | GNAS; GNAS complex locus |
107 | ADCY1; adenylate cyclase 1 |
108 | ADCY2; adenylate cyclase 2 |
109 | ADCY3; adenylate cyclase 3 |
196883 | ADCY4; adenylate cyclase 4 |
111 | ADCY5; adenylate cyclase 5 |
112 | ADCY6; adenylate cyclase 6 |
113 | ADCY7; adenylate cyclase 7 |
114 | ADCY8; adenylate cyclase 8 |
115 | ADCY9; adenylate cyclase 9 |
5566 | PRKACA; protein kinase cAMP-activated catalytic subunit alpha |
5567 | PRKACB; protein kinase cAMP-activated catalytic subunit beta |
5568 | PRKACG; protein kinase cAMP-activated catalytic subunit gamma |
|
Metabolite |
|
Reference |
|
Authors |
Bastepe M, Turan S, He Q |
Title |
Heterotrimeric G proteins in the control of parathyroid hormone actions. |
Journal |
|
Reference |
|
Authors |
Schipani E, Provot S |
Title |
PTHrP, PTH, and the PTH/PTHrP receptor in endochondral bone development. |
Journal |
|
Reference |
|
Authors |
Jilka RL |
Title |
Molecular and cellular mechanisms of the anabolic effect of intermittent PTH. |
Journal |
|
Reference |
|
Authors |
Lee M, Partridge NC |
Title |
Parathyroid hormone signaling in bone and kidney. |
Journal |
|
LinkDB |
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