| Entry |
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| Name |
PTH-PTH1R-PKA signaling pathway
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| Definition |
PTH -> PTH1R -> GNAS -> ADCY -> cAMP -> PKA |
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| Expanded |
5741 -> 5745 -> 2778 -> (107,108,109,196883,111,112,113,114,115) -> C00575 -> (5566+5567+5568) |
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| Class |
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| Type |
Reference
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| Pathway |
| hsa04928 | Parathyroid hormone synthesis, secretion and action |
| hsa04961 | Endocrine and other factor-regulated calcium reabsorption |
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| Gene |
| 5741 | PTH; parathyroid hormone |
| 5745 | PTH1R; parathyroid hormone 1 receptor |
| 2778 | GNAS; GNAS complex locus |
| 107 | ADCY1; adenylate cyclase 1 |
| 108 | ADCY2; adenylate cyclase 2 |
| 109 | ADCY3; adenylate cyclase 3 |
| 196883 | ADCY4; adenylate cyclase 4 |
| 111 | ADCY5; adenylate cyclase 5 |
| 112 | ADCY6; adenylate cyclase 6 |
| 113 | ADCY7; adenylate cyclase 7 |
| 114 | ADCY8; adenylate cyclase 8 |
| 115 | ADCY9; adenylate cyclase 9 |
| 5566 | PRKACA; protein kinase cAMP-activated catalytic subunit alpha |
| 5567 | PRKACB; protein kinase cAMP-activated catalytic subunit beta |
| 5568 | PRKACG; protein kinase cAMP-activated catalytic subunit gamma |
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| Metabolite |
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| Reference |
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| Authors |
Bastepe M, Turan S, He Q |
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| Title |
Heterotrimeric G proteins in the control of parathyroid hormone actions. |
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| Journal |
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| Reference |
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| Authors |
Schipani E, Provot S |
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| Title |
PTHrP, PTH, and the PTH/PTHrP receptor in endochondral bone development. |
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| Journal |
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| Reference |
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| Authors |
Jilka RL |
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| Title |
Molecular and cellular mechanisms of the anabolic effect of intermittent PTH. |
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| Journal |
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| Reference |
|
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| Authors |
Lee M, Partridge NC |
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| Title |
Parathyroid hormone signaling in bone and kidney. |
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| Journal |
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| LinkDB |
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