Homo sapiens (human): 113
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Entry
113 CDS
T01001
Symbol
ADCY7, AC7
Name
(RefSeq) adenylate cyclase 7
KO
K08047
adenylate cyclase 7 [EC:
4.6.1.1
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00230
Purine metabolism
hsa01100
Metabolic pathways
hsa01522
Endocrine resistance
hsa04015
Rap1 signaling pathway
hsa04020
Calcium signaling pathway
hsa04022
cGMP-PKG signaling pathway
hsa04024
cAMP signaling pathway
hsa04062
Chemokine signaling pathway
hsa04072
Phospholipase D signaling pathway
hsa04081
Hormone signaling
hsa04082
Neuroactive ligand signaling
hsa04114
Oocyte meiosis
hsa04211
Longevity regulating pathway
hsa04213
Longevity regulating pathway - multiple species
hsa04261
Adrenergic signaling in cardiomyocytes
hsa04270
Vascular smooth muscle contraction
hsa04371
Apelin signaling pathway
hsa04540
Gap junction
hsa04611
Platelet activation
hsa04713
Circadian entrainment
hsa04714
Thermogenesis
hsa04723
Retrograde endocannabinoid signaling
hsa04724
Glutamatergic synapse
hsa04725
Cholinergic synapse
hsa04727
GABAergic synapse
hsa04750
Inflammatory mediator regulation of TRP channels
hsa04911
Insulin secretion
hsa04912
GnRH signaling pathway
hsa04913
Ovarian steroidogenesis
hsa04914
Progesterone-mediated oocyte maturation
hsa04915
Estrogen signaling pathway
hsa04916
Melanogenesis
hsa04918
Thyroid hormone synthesis
hsa04921
Oxytocin signaling pathway
hsa04923
Regulation of lipolysis in adipocytes
hsa04925
Aldosterone synthesis and secretion
hsa04926
Relaxin signaling pathway
hsa04927
Cortisol synthesis and secretion
hsa04928
Parathyroid hormone synthesis, secretion and action
hsa04934
Cushing syndrome
hsa04935
Growth hormone synthesis, secretion and action
hsa04970
Salivary secretion
hsa04971
Gastric acid secretion
hsa04972
Pancreatic secretion
hsa04976
Bile secretion
hsa05032
Morphine addiction
hsa05163
Human cytomegalovirus infection
hsa05166
Human T-cell leukemia virus 1 infection
hsa05200
Pathways in cancer
hsa05207
Chemical carcinogenesis - receptor activation
hsa05414
Dilated cardiomyopathy
Network
nt06167
Human cytomegalovirus (HCMV)
nt06234
cAMP signaling (cancer)
nt06310
CRH-ACTH-cortisol signaling
nt06318
CaSR-PTH signaling
nt06322
TRH-TSH-TH signaling
nt06323
KISS1-GnRH-LH/FSH-E2 signaling
nt06324
GHRH-GH-IGF signaling
nt06360
Cushing syndrome
nt06529
Thermogenesis
nt06533
Chemokine signaling
nt06544
Neuroactive ligand signaling
Element
N00288
PTH-PTH1R-PKA signaling pathway
N00297
ACTH-cortisol signaling pathway
N00298
CYP11B1-CYP11B2 fusion to ACTH-cortisol signaling pathway
N00321
Mutation-activated GNAS to ACTH-cortisol signaling pathway
N00324
CRHR-PKA-ACTH signaling pathway
N00325
Mutation-inactivated RASD1 to CRHR-PKA-ACTH signaling pathway
N00326
Mutation-activated GNAS to CRHR-PKA-ACTH signaling pathway
N00327
Mutation-inactivated PRKAR1A to CRHR-PKA-ACTH signaling pathway
N00403
CX3CR1-GNAI-AC-PKA signaling pathway
N00782
TSH-TG signaling pathway
N00885
LHCGR-GNAS-PKA signaling pathway
N00910
GHRHR-PKA-GH signaling pathway
N00922
FSHR-GNAS-PKA signaling pathway
N01345
EP/NE-ADRB-cAMP signaling pathway
N01346
Nicotine/NNK to cAMP signaling pathway
N01688
ADRB3-UCP1 signaling pathway
N01766
CX3CR1-GNAI-AC signaling pathway
N01878
Glutamate-GRM-GNAQ/S signaling pathway
N01879
Glutamate-GRM-GNAI/O signaling pathway
N01888
GABA-GABBR-GNAI/O signaling pathway
N01901
Serotonin-HTR1/5-GNAI/O signaling pathway
N01903
Norepinephrine-ADRA2-GNAI/O signaling pathway
N01904
Norepinephrine-ADRB-GNAS signaling pathway
N01905
AC-PKA-HCN signaling
N01908
ADP/UDP-glucose-P2RY-GNAI/O signaling pathway
N01913
Melanocortin receptor signaling, MSH
N01914
Melanocortin receptor signaling, AgRP
Drug target
Colforsin (
DG02877
):
D01697
<JP>
D03584
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09100 Metabolism
09104 Nucleotide metabolism
00230 Purine metabolism
113 (ADCY7)
09130 Environmental Information Processing
09132 Signal transduction
04015 Rap1 signaling pathway
113 (ADCY7)
04072 Phospholipase D signaling pathway
113 (ADCY7)
04024 cAMP signaling pathway
113 (ADCY7)
04022 cGMP-PKG signaling pathway
113 (ADCY7)
09133 Signaling molecules and interaction
04082 Neuroactive ligand signaling
113 (ADCY7)
04081 Hormone signaling
113 (ADCY7)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
113 (ADCY7)
04062 Chemokine signaling pathway
113 (ADCY7)
09152 Endocrine system
04911 Insulin secretion
113 (ADCY7)
04923 Regulation of lipolysis in adipocytes
113 (ADCY7)
04913 Ovarian steroidogenesis
113 (ADCY7)
04915 Estrogen signaling pathway
113 (ADCY7)
04921 Oxytocin signaling pathway
113 (ADCY7)
04926 Relaxin signaling pathway
113 (ADCY7)
04935 Growth hormone synthesis, secretion and action
113 (ADCY7)
04918 Thyroid hormone synthesis
113 (ADCY7)
04928 Parathyroid hormone synthesis, secretion and action
113 (ADCY7)
04925 Aldosterone synthesis and secretion
113 (ADCY7)
04927 Cortisol synthesis and secretion
113 (ADCY7)
09154 Digestive system
04970 Salivary secretion
113 (ADCY7)
04971 Gastric acid secretion
113 (ADCY7)
04972 Pancreatic secretion
113 (ADCY7)
04976 Bile secretion
113 (ADCY7)
09156 Nervous system
04724 Glutamatergic synapse
113 (ADCY7)
04727 GABAergic synapse
113 (ADCY7)
04725 Cholinergic synapse
113 (ADCY7)
04723 Retrograde endocannabinoid signaling
113 (ADCY7)
09157 Sensory system
04750 Inflammatory mediator regulation of TRP channels
113 (ADCY7)
09149 Aging
04211 Longevity regulating pathway
113 (ADCY7)
04213 Longevity regulating pathway - multiple species
113 (ADCY7)
09159 Environmental adaptation
04713 Circadian entrainment
113 (ADCY7)
04714 Thermogenesis
113 (ADCY7)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
113 (ADCY7)
05207 Chemical carcinogenesis - receptor activation
113 (ADCY7)
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
113 (ADCY7)
05163 Human cytomegalovirus infection
113 (ADCY7)
09165 Substance dependence
05032 Morphine addiction
113 (ADCY7)
09166 Cardiovascular disease
05414 Dilated cardiomyopathy
113 (ADCY7)
09167 Endocrine and metabolic disease
04934 Cushing syndrome
113 (ADCY7)
09176 Drug resistance: antineoplastic
01522 Endocrine resistance
113 (ADCY7)
Enzymes [BR:
hsa01000
]
4. Lyases
4.6 Phosphorus-oxygen lyases
4.6.1 Phosphorus-oxygen lyases (only sub-subclass identified to date)
4.6.1.1 adenylate cyclase
113 (ADCY7)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Guanylate_cyc
Adcy_cons_dom
AC_N
Motif
Other DBs
NCBI-GeneID:
113
NCBI-ProteinID:
NP_001105
OMIM:
600385
HGNC:
238
Ensembl:
ENSG00000121281
UniProt:
P51828
Q86YI0
LinkDB
All DBs
Position
16:50244699..50318135
Genome browser
AA seq
1080 aa
AA seq
DB search
MPAKGRYFLNEGEEGPDQDALYEKYQLTSQHGPLLLTLLLVAATACVALIIIAFSQGDPS
RHQAILGMAFLVLAVFAALSVLMYVECLLRRWLRALALLTWACLVALGYVLVFDAWTKAA
CAWEQVPFFLFIVFVVYTLLPFSMRGAVAVGAVSTASHLLVLGSLMGGFTTPSVRVGLQL
LANAVIFLCGNLTGAFHKHQMQDASRDLFTYTVKCIQIRRKLRIEKRQQENLLLSVLPAH
ISMGMKLAIIERLKEHGDRRCMPDNNFHSLYVKRHQNVSILYADIVGFTQLASDCSPKEL
VVVLNELFGKFDQIAKANECMRIKILGDCYYCVSGLPVSLPTHARNCVKMGLDMCQAIKQ
VREATGVDINMRVGIHSGNVLCGVIGLRKWQYDVWSHDVSLANRMEAAGVPGRVHITEAT
LKHLDKAYEVEDGHGQQRDPYLKEMNIRTYLVIDPRSQQPPPPSQHLPRPKGDAALKMRA
SVRMTRYLESWGAARPFAHLNHRESVSSGETHVPNGRRPKSVPQRHRRTPDRSMSPKGRS
EDDSYDDEMLSAIEGLSSTRPCCSKSDDFYTFGSIFLEKGFEREYRLAPIPRARHDFACA
SLIFVCILLVHVLLMPRTAALGVSFGLVACVLGLVLGLCFATKFSRCCPARGTLCTISER
VETQPLLRLTLAVLTIGSLLTVAIINLPLMPFQVPELPVGNETGLLAASSKTRALCEPLP
YYTCSCVLGFIACSVFLRMSLEPKVVLLTVALVAYLVLFNLSPCWQWDCCGQGLGNLTKP
NGTTSGTPSCSWKDLKTMTNFYLVLFYITLLTLSRQIDYYCRLDCLWKKKFKKEHEEFET
MENVNRLLLENVLPAHVAAHFIGDKLNEDWYHQSYDCVCVMFASVPDFKVFYTECDVNKE
GLECLRLLNEIIADFDELLLKPKFSGVEKIKTIGSTYMAAAGLSVASGHENQELERQHAH
IGVMVEFSIALMSKLDGINRHSFNSFRLRVGINHGPVIAGVIGARKPQYDIWGNTVNVAS
RMESTGELGKIQVTEETCTILQGLGYSCECRGLINVKGKGELRTYFVCTDTAKFQGLGLN
NT seq
3243 nt
NT seq
+upstream
nt +downstream
nt
atgccagccaaggggcgctacttcctcaacgagggcgaggagggccctgaccaagatgcg
ctctacgagaagtaccagctcaccagccagcatgggccgctgctgctcacgctcctgctg
gtggccgccactgcctgcgtggccctcatcatcattgccttcagccagggggacccctcc
agacaccaggccattctgggcatggcgttcctggtgctggcggtgtttgcggccctctct
gtgctgatgtacgtcgagtgtctcctgcggcgctggctcagggccttggcgctgctcacc
tgggcctgcttggtggcgctgggctatgtgctggtgttcgacgcatggacaaaggcggcc
tgtgcgtgggagcaggtgcccttcttcctgttcattgtcttcgtggtgtacacactactg
cccttcagcatgcggggcgctgtcgccgttggggccgtctccactgcctcccacctcctg
gtgctcggttctttgatgggaggcttcacgacacccagtgtccgggtggggctgcagctg
ctggccaacgcagtcatcttcctgtgtgggaacctgacaggcgccttccacaagcaccaa
atgcaggatgcatcccgggacctcttcacctacactgtgaagtgcatccagatccgccgg
aagctgcgcatcgagaagcgccagcaggagaacctgctgctgtcagtgcttccggcccac
atctccatgggcatgaagctggccatcatcgaacggctcaaggagcatggtgaccgtcgc
tgcatgcctgacaacaacttccacagcctctacgtcaagaggcaccagaatgtcagcatc
ctctatgcggacatcgtgggcttcacgcagctggccagcgactgttctcccaaggagctg
gtggtggtgctgaatgagctctttggcaagttcgaccagatcgccaaggccaacgagtgc
atgcgaatcaagatcctcggcgactgctactactgtgtatcgggcctgcccgtgtcgctg
cctacccacgcccggaactgcgtgaagatggggctggacatgtgccaggccatcaagcag
gtgcgggaggccacgggcgtggacatcaacatgcgtgtgggcatacactcggggaatgtg
ctgtgcggggtcatcgggctgcgcaagtggcagtatgacgtgtggtcccacgacgtgtcc
ctggccaaccggatggaggcagccggagtacccggccgggtgcacatcacggaggccacg
ctaaagcacctggacaaggcgtacgaggtggaggatgggcacgggcagcagcgggacccc
tacctcaaggagatgaacatccgcacctacctggtcatcgacccccggagccagcagcca
cccccgcccagccaacacctccccaggcccaagggggacgcggccctgaagatgcgggcg
tcagtgcgcatgacccggtacctcgagtcctggggggcggcacggccctttgcacatctc
aaccaccgtgagagcgtgagcagtggtgagacccacgtccccaacgggcggaggcctaag
agcgttccccagcgccaccgccggaccccagacagaagcatgtcccccaaggggcggtcg
gaggatgactcgtacgatgacgagatgctgtcagccattgaggggctcagctccacgagg
ccctgctgctccaagtccgatgacttctacacctttgggtccatcttcctggagaagggc
tttgagcgcgagtaccgcctggcacccatcccccgggcccgccacgactttgcctgcgcc
agcctgatcttcgtctgcatcctgctcgtccatgtcctgctcatgcccaggacggcggca
ctgggtgtgtccttcgggctggtggcctgtgtactggggctggtgctgggcctgtgcttt
gccaccaagttctcgaggtgctgcccagctcgggggacgctctgcactatctctgagagg
gtggagacacagcccctgctgaggctgaccctggccgtcctgaccatcggcagcctgctc
actgtggccatcatcaacctgcccctgatgcctttccaagttccagagctgcctgttggc
aatgagacaggcctactggccgcgagcagcaagacaagagccctgtgtgagcccctcccg
tactacacctgcagctgtgtcctgggcttcatcgcctgctcggtcttcctgaggatgagc
ctggagccaaaggttgtgctgctgacagtggccctggtggcctacctggtgctcttcaac
ctctccccatgctggcagtgggactgctgcggccaaggcctgggcaacctcaccaagccc
aacggcaccaccagtggcacccctagctgttcctggaaggacctgaagaccatgaccaat
ttctacctggtcctgttctacatcaccctgcttacactctccagacagattgactattac
tgccgcttggactgcctatggaagaagaagttcaagaaggagcacgaggagtttgagacc
atggagaacgtgaaccgccttcttctggagaacgtcctgccagcccacgtggctgcccac
tttatcggtgacaagttaaacgaggactggtaccatcagtcctatgactgcgtctgtgtc
atgtttgcctccgtgccggacttcaaagtgttctacacagagtgcgatgtcaacaaagaa
gggctggagtgcctacgcctgctcaatgagatcattgccgacttcgacgagctcctactg
aagcccaagttcagcggcgtggagaagatcaagaccatcggcagcacgtacatggcagct
gcagggctcagcgtcgcctcagggcacgagaaccaggagctggagcggcagcatgcccac
attggtgtcatggtggagttcagcatcgccctgatgagtaagctggacggcatcaacagg
cactccttcaactccttccgcctccgcgtcggcataaaccatgggcctgtgattgctgga
gtgattggggcccgaaaacctcagtatgacatctggggaaacactgtcaatgtggccagc
cgaatggaaagcactggagaacttgggaaaatccaggttaccgaggagacctgcaccatc
ctccagggcctcgggtactcttgtgaatgccgtggcctgatcaacgtcaaaggcaaaggc
gagctgaggacttactttgtctgtacggacactgccaagtttcaggggctggggctgaac
tga
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