Homo sapiens (human): 114
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Entry
114 CDS
T01001
Symbol
ADCY8, AC8, ADCY3, HBAC1
Name
(RefSeq) adenylate cyclase 8
KO
K08048
adenylate cyclase 8 [EC:
4.6.1.1
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00230
Purine metabolism
hsa01100
Metabolic pathways
hsa01522
Endocrine resistance
hsa04015
Rap1 signaling pathway
hsa04020
Calcium signaling pathway
hsa04022
cGMP-PKG signaling pathway
hsa04024
cAMP signaling pathway
hsa04062
Chemokine signaling pathway
hsa04072
Phospholipase D signaling pathway
hsa04081
Hormone signaling
hsa04114
Oocyte meiosis
hsa04211
Longevity regulating pathway
hsa04213
Longevity regulating pathway - multiple species
hsa04261
Adrenergic signaling in cardiomyocytes
hsa04270
Vascular smooth muscle contraction
hsa04371
Apelin signaling pathway
hsa04540
Gap junction
hsa04611
Platelet activation
hsa04713
Circadian entrainment
hsa04714
Thermogenesis
hsa04720
Long-term potentiation
hsa04723
Retrograde endocannabinoid signaling
hsa04724
Glutamatergic synapse
hsa04725
Cholinergic synapse
hsa04727
GABAergic synapse
hsa04742
Taste transduction
hsa04750
Inflammatory mediator regulation of TRP channels
hsa04911
Insulin secretion
hsa04912
GnRH signaling pathway
hsa04913
Ovarian steroidogenesis
hsa04914
Progesterone-mediated oocyte maturation
hsa04915
Estrogen signaling pathway
hsa04916
Melanogenesis
hsa04918
Thyroid hormone synthesis
hsa04921
Oxytocin signaling pathway
hsa04923
Regulation of lipolysis in adipocytes
hsa04925
Aldosterone synthesis and secretion
hsa04926
Relaxin signaling pathway
hsa04927
Cortisol synthesis and secretion
hsa04928
Parathyroid hormone synthesis, secretion and action
hsa04934
Cushing syndrome
hsa04935
Growth hormone synthesis, secretion and action
hsa04970
Salivary secretion
hsa04971
Gastric acid secretion
hsa04972
Pancreatic secretion
hsa04976
Bile secretion
hsa05032
Morphine addiction
hsa05163
Human cytomegalovirus infection
hsa05166
Human T-cell leukemia virus 1 infection
hsa05200
Pathways in cancer
hsa05207
Chemical carcinogenesis - receptor activation
hsa05414
Dilated cardiomyopathy
Network
nt06167
Human cytomegalovirus (HCMV)
nt06234
cAMP signaling (cancer)
nt06310
CRH-ACTH-cortisol signaling
nt06318
CaSR-PTH signaling
nt06322
TRH-TSH-TH signaling
nt06323
KISS1-GnRH-LH/FSH-E2 signaling
nt06324
GHRH-GH-IGF signaling
nt06360
Cushing syndrome
nt06529
Thermogenesis
nt06533
Chemokine signaling
Element
N00288
PTH-PTH1R-PKA signaling pathway
N00297
ACTH-cortisol signaling pathway
N00298
CYP11B1-CYP11B2 fusion to ACTH-cortisol signaling pathway
N00321
Mutation-activated GNAS to ACTH-cortisol signaling pathway
N00324
CRHR-PKA-ACTH signaling pathway
N00325
Mutation-inactivated RASD1 to CRHR-PKA-ACTH signaling pathway
N00326
Mutation-activated GNAS to CRHR-PKA-ACTH signaling pathway
N00327
Mutation-inactivated PRKAR1A to CRHR-PKA-ACTH signaling pathway
N00403
CX3CR1-GNAI-AC-PKA signaling pathway
N00782
TSH-TG signaling pathway
N00885
LHCGR-GNAS-PKA signaling pathway
N00910
GHRHR-PKA-GH signaling pathway
N00922
FSHR-GNAS-PKA signaling pathway
N01345
EP/NE-ADRB-cAMP signaling pathway
N01346
Nicotine/NNK to cAMP signaling pathway
N01688
ADRB3-UCP1 signaling pathway
N01766
CX3CR1-GNAI-AC signaling pathway
Drug target
Colforsin (
DG02877
):
D01697
<JP>
D03584
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09100 Metabolism
09104 Nucleotide metabolism
00230 Purine metabolism
114 (ADCY8)
09130 Environmental Information Processing
09132 Signal transduction
04015 Rap1 signaling pathway
114 (ADCY8)
04072 Phospholipase D signaling pathway
114 (ADCY8)
04024 cAMP signaling pathway
114 (ADCY8)
04022 cGMP-PKG signaling pathway
114 (ADCY8)
09133 Signaling molecules and interaction
04081 Hormone signaling
114 (ADCY8)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
114 (ADCY8)
04062 Chemokine signaling pathway
114 (ADCY8)
09152 Endocrine system
04911 Insulin secretion
114 (ADCY8)
04923 Regulation of lipolysis in adipocytes
114 (ADCY8)
04913 Ovarian steroidogenesis
114 (ADCY8)
04915 Estrogen signaling pathway
114 (ADCY8)
04921 Oxytocin signaling pathway
114 (ADCY8)
04926 Relaxin signaling pathway
114 (ADCY8)
04935 Growth hormone synthesis, secretion and action
114 (ADCY8)
04918 Thyroid hormone synthesis
114 (ADCY8)
04928 Parathyroid hormone synthesis, secretion and action
114 (ADCY8)
04925 Aldosterone synthesis and secretion
114 (ADCY8)
04927 Cortisol synthesis and secretion
114 (ADCY8)
09154 Digestive system
04970 Salivary secretion
114 (ADCY8)
04971 Gastric acid secretion
114 (ADCY8)
04972 Pancreatic secretion
114 (ADCY8)
04976 Bile secretion
114 (ADCY8)
09156 Nervous system
04724 Glutamatergic synapse
114 (ADCY8)
04727 GABAergic synapse
114 (ADCY8)
04725 Cholinergic synapse
114 (ADCY8)
04720 Long-term potentiation
114 (ADCY8)
04723 Retrograde endocannabinoid signaling
114 (ADCY8)
09157 Sensory system
04742 Taste transduction
114 (ADCY8)
04750 Inflammatory mediator regulation of TRP channels
114 (ADCY8)
09149 Aging
04211 Longevity regulating pathway
114 (ADCY8)
04213 Longevity regulating pathway - multiple species
114 (ADCY8)
09159 Environmental adaptation
04713 Circadian entrainment
114 (ADCY8)
04714 Thermogenesis
114 (ADCY8)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
114 (ADCY8)
05207 Chemical carcinogenesis - receptor activation
114 (ADCY8)
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
114 (ADCY8)
05163 Human cytomegalovirus infection
114 (ADCY8)
09165 Substance dependence
05032 Morphine addiction
114 (ADCY8)
09166 Cardiovascular disease
05414 Dilated cardiomyopathy
114 (ADCY8)
09167 Endocrine and metabolic disease
04934 Cushing syndrome
114 (ADCY8)
09176 Drug resistance: antineoplastic
01522 Endocrine resistance
114 (ADCY8)
Enzymes [BR:
hsa01000
]
4. Lyases
4.6 Phosphorus-oxygen lyases
4.6.1 Phosphorus-oxygen lyases (only sub-subclass identified to date)
4.6.1.1 adenylate cyclase
114 (ADCY8)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Guanylate_cyc
AC_N
Adcy_cons_dom
TBK1_ULD
Motif
Other DBs
NCBI-GeneID:
114
NCBI-ProteinID:
NP_001106
OMIM:
103070
HGNC:
239
Ensembl:
ENSG00000155897
UniProt:
P40145
A0A0K0K1K3
Q4F7X0
LinkDB
All DBs
Position
8:complement(130780301..131040909)
Genome browser
AA seq
1251 aa
AA seq
DB search
MELSDVRCLTGSEELYTIHPTPPAGDGRSASRPQRLLWQTAVRHITEQRFIHGHRGGSGS
GSGGSGKASDPAGGGPNHHAPQLSGDSALPLYSLGPGERAHSTCGTKVFPERSGSGSASG
SGGGGDLGFLHLDCAPSNSDFFLNGGYSYRGVIFPTLRNSFKSRDLERLYQRYFLGQRRK
SEVVMNVLDVLTKLTLLVLHLSLASAPMDPLKGILLGFFTGIEVVICALVVVRKDTTSHT
YLQYSGVVTWVAMTTQILAAGLGYGLLGDGIGYVLFTLFATYSMLPLPLTWAILAGLGTS
LLQVILQVVIPRLAVISINQVVAQAVLFMCMNTAGIFISYLSDRAQRQAFLETRRCVEAR
LRLETENQRQERLVLSVLPRFVVLEMINDMTNVEDEHLQHQFHRIYIHRYENVSILFADV
KGFTNLSTTLSAQELVRMLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPRQDHAH
CCVEMGLSMIKTIRYVRSRTKHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKL
ESGGIPGRIHISKATLDCLNGDYNVEEGHGKERNEFLRKHNIETYLIKQPEDSLLSLPED
IVKESVSSSDRRNSGATFTEGSWSPELPFDNIVGKQNTLAALTRNSINLLPNHLAQALHV
QSGPEEINKRIEHTIDLRSGDKLRREHIKPFSLMFKDSSLEHKYSQMRDEVFKSNLVCAF
IVLLFITAIQSLLPSSRVMPMTIQFSILIMLHSALVLITTAEDYKCLPLILRKTCCWINE
TYLARNVIIFASILINFLGAILNILWCDFDKSIPLKNLTFNSSAVFTDICSYPEYFVFTG
VLAMVTCAVFLRLNSVLKLAVLLIMIAIYALLTETVYAGLFLRYDNLNHSGEDFLGTKEV
SLLLMAMFLLAVFYHGQQLEYTARLDFLWRVQAKEEINEMKELREHNENMLRNILPSHVA
RHFLEKDRDNEELYSQSYDAVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDE
LLGEDRFQDIEKIKTIGSTYMAVSGLSPEKQQCEDKWGHLCALADFSLALTESIQEINKH
SFNNFELRIGISHGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGRIQVPEETYLIL
KDQGFAFDYRGEIYVKGISEQEGKIKTYFLLGRVQPNPFILPPRRLPGQYSLAAVVLGLV
QSLNRQRQKQLLNENNNTGIIKGHYNRRTLLSPSGTEPGAQAEGTDKSDLP
NT seq
3756 nt
NT seq
+upstream
nt +downstream
nt
atggagctctccgatgtgcgctgccttacaggcagcgaggaactctacaccatccacccg
acgcccccggccggcgacggcaggagcgcctcccggccgcagcggctgctgtggcagacg
gcggtgcgacacatcacggagcagcgcttcattcacgggcaccggggaggcagcggcagc
gggagtggaggctcgggcaaagcctcggaccctgcgggcggcggccccaaccaccacgcg
ccgcagctgtcaggcgactcggcgctgcccctctactcgctgggcccgggagagcgagcg
cacagcacctgcggcaccaaagtcttcccggaacgcagcgggagcggcagtgccagcggc
agcggaggcgggggcgacctgggcttcctgcaccttgactgtgcccctagcaactcggat
ttctttcttaatgggggctatagctaccgaggggtcattttccccaccctgcgcaactcc
ttcaaatctcgggatttggaacgcctctaccagcgctatttcttgggccaaaggcgcaaa
tcggaagtggtgatgaacgtgctggacgtgctgaccaaactcactctcttggtcctacac
ttgagcctggcctcggcccccatggacccgctcaagggcatcctgctgggcttcttcacc
ggcattgaggtagtgatctgcgccctggtggtggtcaggaaggacaccacctcccacacg
tacctgcagtacagcggcgtggtcacctgggtggccatgaccacccagatcctggcagca
ggcctcggctacgggctcctgggcgacggcataggctacgtgctcttcacgctcttcgcc
acctacagtatgctgccgctgccgctcacctgggccatcctggccggcctgggcacctcg
ctgctgcaggtcatcctccaagtggtcataccccggctggcggtcatttccatcaaccag
gttgtggcccaggcagtgctattcatgtgtatgaacacagctggaatcttcatcagttac
ctgtcagaccgggcccagcgccaagctttcctggagactcggaggtgtgtggaggccagg
ctgcgcctggagacagagaaccaaagacaggagcggctcgtgctttctgtgctcccccgg
tttgttgtcctggaaatgatcaacgacatgaccaatgtggaagatgagcacctgcagcac
cagttccatcggatctacatccatcgctatgagaacgtcagtattctttttgcagatgtt
aaaggatttaccaacctctccacgaccttgtctgctcaggagctggtcaggatgctcaac
gagctctttgccagatttgatcgactggcccatgagcatcactgccttcgtattaaaatc
ctgggggactgctactactgcgtgtctggacttcctgagccccgccaggaccatgcccac
tgctgtgttgaaatgggtctcagcatgatcaaaaccatcaggtatgtgcggtcaaggaca
aaacacgatgttgacatgaggattggaatccactccggctcggtgctgtgcggtgttttg
ggactaaggaagtggcagtttgatgtctggtcttgggatgtggatattgcaaacaaactc
gaatctggaggaatccctgggaggattcacatttccaaagccacgctggactgtctcaac
ggtgactataacgtggaagagggccatggtaaagagaggaatgaattcctgaggaagcat
aatatcgaaacttacttaattaagcagcctgaggacagtctgctgtccttgcctgaagat
atcgtcaaggagtcagtgagctcctcagaccggagaaacagtggggccacattcactgaa
ggatcctggagccctgaactgccctttgataatatcgtggggaaacagaatactctggct
gccctaacaagaaattcaataaatctgcttccaaaccatcttgcacaagctttgcatgtc
cagtctgggcctgaggaaattaacaagagaatagaacataccatcgacttgcggagtggc
gataaattgagaagagagcatatcaagccattctcactgatgtttaaagactccagcctg
gagcacaagtattctcaaatgagggatgaagtgttcaagtcaaacttggtctgtgcattt
atcgttcttctatttatcacggcaatacaaagtttgcttccttcttcaagagtgatgcca
atgaccatccagttctccattctgattatgctgcactcggctctggtcctcatcaccaca
gcagaggattataaatgtttgcccctcatcctccggaaaacttgctgttggattaatgag
acctatttggcccggaacgtcatcatctttgcatccattttgattaatttcctgggtgcc
atcttaaatatcctgtggtgtgattttgacaagtcgatacccttgaagaacctgactttc
aattcctcagctgtgtttacagatatctgctcctacccagagtactttgtcttcacgggg
gtgttggccatggtgacctgtgcagttttcctccggctgaactccgtcctgaagctggca
gtgctgctgatcatgattgccatctatgccctgctcactgagaccgtctacgcaggcctc
tttctgcgttatgacaacctcaaccacagtggagaagatttcctggggaccaaggaggta
tcactgctactgatggccatgttcctcctggctgtgttctaccatggacagcagctggag
tacacagcccgcctggacttcctttggcgagtacaggccaaagaggagatcaatgagatg
aaggagctgagggaacacaatgagaacatgctccggaatatcttacccagccatgtggcc
cgccatttcctagagaaggaccgagacaatgaggagctgtattctcaatcctatgatgct
gttggggtgatgtttgcctccatcccaggatttgcggacttttactctcagactgaaatg
aataaccagggagtggaatgcctgcgcttgctcaatgagatcattgctgacttcgatgag
ttgcttggtgaagaccgatttcaagacattgaaaagattaagaccattggcagcacctac
atggccgtgtcaggcctgtcacctgaaaaacagcaatgtgaagacaagtggggacatttg
tgtgctctggctgacttctcactcgccctgacagaaagcatacaggagatcaacaagcat
tcattcaacaattttgaactccggattggcatcagccacggctcagtggtagctggcgtt
atcggcgctaagaaaccacagtatgacatttggggcaaaactgtgaacctggcaagccga
atggacagcacgggggttagtggccggatccaagtcccagaggagacctatctcatcctg
aaggaccagggctttgcctttgattaccgaggggagatctatgtgaagggtatcagtgaa
caggaaggaaaaatcaaaacgtactttcttctgggaagagtccaacccaacccattcatc
ttgcccccaagaagactgcctgggcagtactccctggccgcggttgtcctgggacttgtc
cagtccctcaataggcaaaggcagaagcagctactcaatgagaacaacaacacaggaatc
atcaagggtcattacaaccggcggactttgttgtcacccagcggcacagagcctggagcc
caggctgaaggcaccgacaaatctgatttgccataa
DBGET
integrated database retrieval system