KEGG   NETWORK: N00373
Entry
N00373                      Network                                
Name
HPV E6 to NFX1-mediated transcription
Definition
(E6+UBE3A) -| NFX1 =| TERT
  Expanded
(K21807+7337) -| 4799 =| 7015
Class
nt06140 Transcription (viruses)
nt06166 Human papillomavirus (HPV)
Type
Pathogen
Pathway
hsa05165  Human papillomavirus infection
Disease
H00030  Cervical cancer
Gene
7337  UBE3A; ubiquitin protein ligase E3A
4799  NFX1; nuclear transcription factor, X-box binding 1
7015  TERT; telomerase reverse transcriptase
Perturbant
K21807 (E6)  E6; HPV protein E6
Reference
  Authors
Yugawa T, Kiyono T
  Title
Molecular mechanisms of cervical carcinogenesis by high-risk human papillomaviruses: novel functions of E6 and E7 oncoproteins.
  Journal
Rev Med Virol 19:97-113 (2009)
DOI:10.1002/rmv.605
Reference
  Authors
Chung CH, Gillison ML
  Title
Human papillomavirus in head and neck cancer: its role in pathogenesis and clinical implications.
  Journal
Clin Cancer Res 15:6758-62 (2009)
DOI:10.1158/1078-0432.CCR-09-0784
Reference
  Authors
Xu M, Luo W, Elzi DJ, Grandori C, Galloway DA
  Title
NFX1 interacts with mSin3A/histone deacetylase to repress hTERT transcription in keratinocytes.
  Journal
Mol Cell Biol 28:4819-28 (2008)
DOI:10.1128/MCB.01969-07
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