Entry Name HCMV IE1-72/IE2-86 to PI3K signaling pathway
Definition (IE1-72,IE2-86) -> PI3K
Expanded (K22774,K22775) -> (5290,5291,5293)
Class nt06167 Human cytomegalovirus (HCMV)
Type Pathogen
Pathway hsa05163 Human cytomegalovirus infection
Disease H00368 Cytomegalovirus infection
Gene 5290 PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
5291 PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
5293 PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
Perturbant K22774 (IE1-72) UL123; HCMV immediate-early protein 1
K22775 (IE2-86) UL122; Cytomegalovirus viral transcription factor IE2
Reference Authors Price P (ed).
Title Manifestations of Cytomegalovirus Infection
Journal Reference Authors Michaelis M, Doerr HW, Cinatl J
Title The story of human cytomegalovirus and cancer: increasing evidence and open questions.
Journal Reference Authors Cobbs CS, Soroceanu L, Denham S, Zhang W, Kraus MH
Title Modulation of oncogenic phenotype in human glioma cells by cytomegalovirus IE1-mediated mitogenicity.
Journal Reference Authors Yu Y, Alwine JC
Title Human cytomegalovirus major immediate-early proteins and simian virus 40 large T antigen can inhibit apoptosis through activation of the phosphatidylinositide 3'-OH kinase pathway and the cellular kinase Akt.
Journal LinkDB All DBs
