KEGG   NETWORK: N00415
Entry
N00415                      Network                                
Name
IL10 family to Jak-STAT signaling pathway
Definition
(IL10,IL19,IL20,IL22,IL24,IL26) -> ((IL10RB+(IL10RA,IL20RA,IL22RA1)) -> (JAK1+TYK2) -> STAT3
  Expanded
(3586,29949,50604,50616,11009,55801) -> ((3588+(3587,53832,58985)) -> (3716+7297) -> 6774
Class
nt06518 JAK-STAT signaling
nt06150 Cytokine-cytokine receptor interaction (viruses)
nt06167 Human cytomegalovirus (HCMV)
Type
Reference
Pathway
hsa04630  JAK-STAT signaling pathway
Gene
3586  IL10; interleukin 10
29949  IL19; interleukin 19
50604  IL20; interleukin 20
50616  IL22; interleukin 22
11009  IL24; interleukin 24
55801  IL26; interleukin 26
3588  IL10RB; interleukin 10 receptor subunit beta
3587  IL10RA; interleukin 10 receptor subunit alpha
53832  IL20RA; interleukin 20 receptor subunit alpha
58985  IL22RA1; interleukin 22 receptor subunit alpha 1
3716  JAK1; Janus kinase 1
7297  TYK2; tyrosine kinase 2
6774  STAT3; signal transducer and activator of transcription 3
Reference
  Authors
Shi J, Li J, Guan H, Cai W, Bai X, Fang X, Hu X, Wang Y, Wang H, Zheng Z, Su L, Hu D, Zhu X
  Title
Anti-fibrotic actions of interleukin-10 against hypertrophic scarring by activation of PI3K/AKT and STAT3 signaling pathways in scar-forming fibroblasts.
  Journal
PLoS One 9:e98228 (2014)
DOI:10.1371/journal.pone.0098228
Reference
  Authors
Zhu YP, Brown JR, Sag D, Zhang L, Suttles J
  Title
Adenosine 5'-monophosphate-activated protein kinase regulates IL-10-mediated anti-inflammatory signaling pathways in macrophages.
  Journal
J Immunol 194:584-94 (2015)
DOI:10.4049/jimmunol.1401024
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