| Entry |
|
|---|
| Name |
HIV gp120 to CXCR4-GNAI-PI3K-BAD signaling pathway
|
|---|
| Definition |
Env -> (CXCR4,CCR5) -> GNAI -> PI3K -> PIP3 -> AKT -| BAD |
|---|
| Expanded |
K19287 -> (7852,1234) -> (2770,2771,2773) -> (5290,5291,5293) -> C05981 -> (207,208,10000) -| 572 |
|---|
| Class |
nt06124 Chemokine signaling (viruses)
nt06150 Cytokine-cytokine receptor interaction (viruses)
nt06161 Human immunodeficiency virus type 1 (HIV-1)
|
|---|
| Type |
Pathogen
|
|---|
| Pathway |
| hsa05170 | Human immunodeficiency virus 1 infection |
|
|---|
| Disease |
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|---|
| Gene |
| 7852 | CXCR4; C-X-C motif chemokine receptor 4 |
| 1234 | CCR5; C-C motif chemokine receptor 5 (gene/pseudogene) |
| 2770 | GNAI1; G protein subunit alpha i1 |
| 2771 | GNAI2; G protein subunit alpha i2 |
| 2773 | GNAI3; G protein subunit alpha i3 |
| 5290 | PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha |
| 5291 | PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta |
| 5293 | PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta |
| 207 | AKT1; AKT serine/threonine kinase 1 |
| 208 | AKT2; AKT serine/threonine kinase 2 |
| 10000 | AKT3; AKT serine/threonine kinase 3 |
| 572 | BAD; BCL2 associated agonist of cell death |
|
|---|
| Perturbant |
| K19287 (Env) | gp160; HIV-1 envelope glycoprotein gp160 |
|
|---|
| Metabolite |
| C05981 | Phosphatidylinositol-3,4,5-trisphosphate |
|
|---|
| Reference |
|
|---|
| Authors |
Wu Y, Yoder A |
|---|
| Title |
Chemokine coreceptor signaling in HIV-1 infection and pathogenesis. |
|---|
| Journal |
|
|---|
| Reference |
|
|---|
| Authors |
Choi WT, Duggineni S, Xu Y, Huang Z, An J |
|---|
| Title |
Drug discovery research targeting the CXC chemokine receptor 4 (CXCR4). |
|---|
| Journal |
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|---|
| LinkDB |
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